Results 101 to 110 of about 34,396 (232)

Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia

Haematologica, 2007
Hepcidin is the key regulator of systemic iron homeostasis. We describe the modulation of hepcidin production induced by plasma transfusions in a patient with congenital hypotransferrinemia that offers a unique model in which to study the mechanism of ...
Paola Trombini, Tiziana Coliva, Elizabeta Nemeth, Raffaella Mariani, Tomas Ganz, Andrea Biondi, Alberto Piperno   +6 more
doaj   +1 more source

Novel mutation in addition to functional TMPRSS6 gene polymorphisms originate an IRIDA-like phenotype in an African child [PDF]

, 2019
Iron-refractory iron deficiency anemia (IRIDA) is a rare autosomal recessive anemia often unresponsive to oral iron intake and partially responsive to parenteral iron treatment. The disease originates from mutations in TMPRSS6 gene, encoding Matriptase 2,
Batalha, Sara, Faleiro, Bárbara D., Faustino, Paula, Lavinha, João, Machado, Miguel P., Maia, Raquel, Mendonça, Joana, Vieira, Luís   +7 more
core  

Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study. [PDF]

, 2020
BackgroundFew cross-sectional studies report iron deficiency (ID) prevalence in women of different race/ethnicity and ages in US or Canada.Materials and methodsWe evaluated screening observations on women who participated between 2001-2003 in a cross ...
Acton, Ronald T, Adams, Paul C, Barton, James C, Eckfeldt, John H, Gordeuk, Victor R, Harris, Emily L, Harrison, Helen, McLaren, Christine E, McLaren, Gordon D, Reboussin, David M, Wiener, Howard H   +10 more
core  

c‐MAF Transcriptionally Activates Slc40a1 to Repress Ferroptosis in Sepsis‐Associated Encephalopathy

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
c‐MAF and its downstream target Slc40a1 were identified as key regulators of ferroptosis in septic mouse hippocampi. Neuron‐specific knockdown of either gene aggravated CLP‐induced cognitive deficits and ferroptosis, whereas their overexpression exerted protective effects.
Wenqin Song, Qianni Shen, Hui Zhang, Xueshan Bu, Wenwei Gao, Wei Wang   +5 more
wiley   +1 more source

Lactoferrin efficiently counteracts the inflammation-induced changes of the iron homeostasis system in macrophages [PDF]

, 2017
Human lactoferrin (hLf), an 80-kDa multifunctional iron-binding cationic glycoprotein, is constitutively secreted by exocrine glands and by neutrophils during inflammation. hLf is recognized as a key element in the host immune defense system.
Aisen, Andrews, Baker, Barber, Cairo, Corna, Cutone, De Domenico, Donovan, Frazer, Frioni, Ganz, Ganz, Genin, Legrand, Mackenzie, Mazumder, Miller, Musci, Paesano, Paesano, Paesano, Paesano, Park, Puddu, Puddu, Recalcati, Ross, Scorneaux, Theil, Valenti, Ward   +31 more
core   +2 more sources

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 629-640, March 2026.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy

Haematologica, 2013
Dietary iron absorption is regulated by hepcidin, an iron regulatory protein produced by the liver. Hepcidin production is regulated by iron stores, erythropoiesis and inflammation, but its physiology when repeated blood loss occurs has not been ...
Alan E. Mast, Karen S. Schlumpf, David J. Wright, Bryce Johnson, Simone A. Glynn, Michael P. Busch, Gordana Olbina, Mark Westerman, Elizabeta Nemeth, Tomas Ganz   +9 more
doaj   +1 more source

Hepcidin Expression in Psoriasis Patients

Indian Journal of Dermatology, 2014
Background: Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is an important and recently discovered regulator of iron homeostasis.
Dilek, Nursel, Dilek, Aziz Ramazan, Şahin, Kazım, Kaklikkaya, Neşe, Saral, Yunus   +4 more
openaire   +3 more sources

Longitudinal clinical and preclinical studies identify hetrombopag as a potent chelator for systemic iron overload

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Iron overload (IO) is a pathological condition characterized by excessive iron accumulation, leading to systemic functional impairment. It frequently occurs in patients with congenital or acquired anemia, such as aplastic anemia, who require long‐term transfusions.
Yufei Zhao, Lingxiao Xing, Baohang Zhang, Wenrui Yang, Xiangrong Hu, Xu Liu, Xiawan Yang, Weiru Liang, Yimeng Shi, Jing Hu, Xiaoxia Li, Rui Kang, Guangxin Peng, Yuan Li, Xiao Hu, Youzhen Xiong, Liping Jing, Weiping Yuan, Sidan Li, Fengkui Zhang, Xin Zhao   +20 more
wiley   +1 more source

Prevalence and Risk Factors of Anemia in Pregnant Women Attending Antenatal Clinic at a Medical Center in Accra, Ghana: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Anemia during pregnancy remains a major cause of maternal and infant morbidity in Ghana and has broader socioeconomic implications. Its persistence despite existing interventions indicates that factors such as education, occupation, and nutrition require closer evaluation.
Gifty Amewudah, Frank Twum Aboagye, Frank Quarshie, Martin Owusu Asante, Benjamin Ansah‐Agyei, Joseph Otchere, Philip Narteh Gorleku, Maurice Ofoe Gorleku, Margaret Atuahene, Abena Mantebea Ateko, Daniel Eshun   +10 more
wiley   +1 more source