Results 11 to 20 of about 34,396 (232)
Redox Biology, 2019 In mammals, the iron masterswitch hepcidin efficiently controls iron recycling by the macrophage-liver axis but the exact interplay between macrophages and hepatocytes remains poorly understood.
Inês Silva +3 more
doaj +1 more source
Clinical Journal of the American Society of Nephrology, 2009 Despite the use of erythropoiesis-stimulating agents (ESAs), the anemia of chronic kidney disease (CKD) can be resistant to therapy. Both absolute and functional iron deficiency along with inflammation can contribute to ESA resistance and can be difficult to identify with current-day markers of iron storage.
Brian, Young, Joshua, Zaritsky
openaire +2 more sources
Hepcidin and iron homeostasis during pregnancy. [PDF]
, 2014 Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke +4 more
core +1 more source
Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya. [PDF]
PLoS ONE, 2013 Hepcidin regulation by competing stimuli such as infection and iron deficiency has not been studied in infants and it's yet unknown whether hepcidin regulatory pathways are fully functional in infants.
Tanja Jaeggi +8 more
doaj +1 more source
Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
, 2014 Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
core +1 more source
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013 Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red cells in macrophages and from storage in hepatocytes.
Subha Palaneeswari M. +4 more
openaire +3 more sources
, 2022 The hepcidin is antimicrobial peptide has antimicrobial effects discover before more than a thousand years; it has a great role in iron metabolism and innate immunity. Hepcidin is a regulator of iron homeostasis. Its production is increased by iron excess and inflammation and decreased by hypoxia and anemia.
A., Faraj, Safa, M., Al-Abedy, Naeem
openaire +2 more sources
Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury
Frontiers in Pharmacology, 2019 Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepcidin
Yogesh Scindia +7 more
doaj +1 more source
Ironing out the details: Untangling dietary iron and genetic background in diabetes [PDF]
, 2018 The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health.
Lawson, Heather A, Miranda, Mario A
core +2 more sources
Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins [PDF]
Biomedicines, 2021 The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution. Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which reduces both iron absorption in the gut and export of iron from storage to ultimately decrease ...
Daniela Goncalves Monteiro +7 more
openaire +5 more sources