Iron Status and Analysis of Efficacy and Safety of Ferric Carboxymaltose Treatment in Patients with Inflammatory Bowel Disease [PDF]
, 2012 Background and Aims:We analyzed iron deficiency and the therapeutic response following intravenous ferric carboxymaltose in a large single-center inflammatory bowel disease (IBD) cohort.
Anker SD +45 more
core +1 more source
Phenotyping rare hepcidin deficiency [PDF]
Blood, 2018 In this issue of Blood , Sandhu et al 1 comprehensively catalog the individual data from all reported cases of hepcidin-deficient hemochromatosis related to HAMP , HJV , and TFR2 mutations to determine their phenotype compared with HFE hemochromatosis.
openaire +2 more sources
Iron regulation by hepcidin [PDF]
Journal of Clinical Investigation, 2013 Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body. Physiologically, hepcidin is controlled by iron stores, inflammation, hypoxia, and erythropoiesis. The regulation of hepcidin expression by iron is a complex process that requires the coordination of multiple proteins, including hemojuvelin, bone morphogenetic ...
Ningning, Zhao +2 more
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Hematology, Transfusion and Cell Therapy, 2019 Background: Recently, a small peptide called Hepcidin, was found to have an important role in regulating the iron metabolism in anemia of chronic disease (ACD) patients.
Ketut Suega, Gde Raka Widiana
doaj +1 more source
Expression of an innate immune element (mouse hepcidin-1) in baculovirus expression system and the comparison of its function with synthetic human hepcidin-25 [PDF]
, 2011 Hepcidin is an innate immune element which decreases the iron absorption from diet and iron releasing from macrophage cell. In contrast to the chemical iron chelators, there has been limited effort applied to the specific use of hepcidin as a new drug ...
Alimohammadian, M. +5 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Hepcidin-25 in chronic hemodialysis patients is related to residual kidney function and not to treatment with erythropoiesis stimulating agents. [PDF]
PLoS ONE, 2012 Hepcidin-25, the bioactive form of hepcidin, is a key regulator of iron homeostasis as it induces internalization and degradation of ferroportin, a cellular iron exporter on enterocytes, macrophages and hepatocytes.
Neelke C van der Weerd +14 more
doaj +1 more source
Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]
, 2013 Peer reviewedPublisher ...
Martin, Samuel A.M. +3 more
core +2 more sources
Annals of Gastroenterological Surgery, EarlyView.In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura +9 more
wiley +1 more source
Immune gene expression profiling of Proliferative Kidney Disease in rainbow trout Oncorhynchus mykiss reveals a dominance of anti-inflammatory, antibody and T helper cell-like activities [PDF]
, 2013 Peer reviewedPublisher ...
Gorgoglione, Bartolomeo +3 more
core +2 more sources