Results 11 to 20 of about 2,189 (194)
Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins [PDF]
Biomedicines, 2021 The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution. Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which ...
Daniela Goncalves Monteiro +7 more
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Hepcidin antagonists for potential treatments of disorders with hepcidin excess [PDF]
Frontiers in Pharmacology, 2014 5noThe discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide.
Maria Regoni +4 more
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[Rinsho ketsueki] The Japanese journal of clinical hematology, 2017 Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling macrophages, and from iron-storing hepatocytes. Hepcidin acts by binding to and inactivating the sole cellular iron exporter, ferroportin, which delivers iron to plasma from ...
A. M. Gressner, O. A. Gressner
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Pharmaceuticals, 2018 Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to “hepcidinopathies” ranging from hereditary hemochromatosis to iron-refractory iron deficiency anemia, which are disorders caused by hepcidin deficiency or excess ...
Angeliki Katsarou, Kostas Pantopoulos
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Large Hepatocellular Adenoma Presenting with Iron Deficiency Anemia: A Case Report
Clinical Pediatric Hematology-Oncology, 2023 Hepatocellular adenoma is an uncommon, benign liver tumor usually occurring in patients using estrogen or anabolic androgens and in those with a genetic disease, including glycogen storage disease.
Young Kwon Koh +7 more
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Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders [PDF]
The Scientific World JOURNAL, 2011 Iron is essential for human life, but toxic if present in excess. To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. At the systemic
CAMASCHELLA , CLARA, SILVESTRI L.
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Journal of Marine Science and Engineering, 2020 Hepcidin, an antimicrobial peptide produced by the liver, also controls the iron balance and regeneration in vertebrates. Two types of hepcidin (Hamp1 and Hamp2) have been found in the bodies of black rockfish (Sebastes schlegelii).
Yunqi Ma +7 more
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Frontiers in Marine Science, 2022 Iron is essential for all living things, especially marine organisms, due to its low availability in the marine environment. Iron regulation is key in all vertebrates and is controlled by hepcidin–ferroportin. To improve the knowledge of iron homeostasis
Jhon A. Serna-Duque +4 more
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LPS modulates the expression of iron-related immune genes in two Antarctic notothenoids [PDF]
, 2020 The non-specific immunity can induce iron deprivation as a defense mechanism against potential bacterial pathogens, but little information is available as to its role in Antarctic fish.
Abram +68 more
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Biomolecules, 2020 In this study, the functions of a recombinant propeptide (rProOn-Hep1) and the synthetic FITC-labelled mature peptides sMatOn-Hep1 and sMatOn-Hep2 were analyzed.
Pagaporn Phan-Aram +4 more
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