Results 91 to 100 of about 16,515 (221)

Cáncer hereditario: fundamentos genéticos [PDF]

, 2005
Genetic counseling plays a key role in the BRCA1/BRCA2 and hMLH1/hMSH2/hMSH6 testing process. The initial genetic counselling encounter will determine the appropriateness of the test by collecting a detailed family history and determining the likelihood ...
Caldés, Trinidad
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An American founder mutation in MLH1 [PDF]

, 2012
Mutations in the mismatch repair genes cause Lynch syndrome (LS), conferring high risk of colorectal, endometrial and some other cancers. After the same splice site mutation in the MLH1 gene (c.589‐2A>G) had been observed in four ostensibly unrelated ...
Barnetson, Clendenning, Clendenning, Desai, Dieumegard, Drost, Foulkes, Froggatt, Genin, Genuardi, Goecke, Hampel, Hampel, Hampel, Kowalski, Luce, Lynch, Mangold, Martinez, Moisio, Nyström-Lahti, Offer, Pastrello, Ponz de Leon, Pritchard, Raevaara, Reeve, Stephens, Stephens, Syngal, Takahashi, Viel, Wagner, Yan   +33 more
core   +1 more source

Numbers of mutations to different types of colorectal cancer

BMC Cancer, 2005
Background The numbers of oncogenic mutations required for transformation are uncertain but may be inferred from how cancer frequencies increase with aging. Cancers requiring more mutations will tend to appear later in life.
Tavaré Simon, Aaltonen Lauri A, Järvinen Heikki J, Mecklin Jukka-Pekka, Calabrese Peter, Shibata Darryl   +5 more
doaj   +1 more source

Hereditary Nonpolyposis Colorectal Cancer in Association with Crohn's Disease and Lynch Syndrome: The Importance of a Strict Endoscopic Surveillance. [PDF]

Case Rep Gastroenterol, 2022
Hahn GD, Wetwittayakhlang P, Afif W, Bessissow T, Lakatos PL.   +4 more
europepmc   +1 more source

Pancreatic Cancer in Lynch Syndrome Patients [PDF]

, 2017
Although colorectal cancer (CRC) is the most common cancer type in Lynch syndrome (LS) families, patients have also increased lifetime risk of other types of tumors.
Bujanda Fernández de Pierola, Luis, Herreros Villanueva, Marta   +1 more
core   +3 more sources

Gynaecological surveillance in high risk women [PDF]

, 2016
Increasing availability of genetic testing and falling costs of the tests suggests that growing numbers of unaffected women will be identified worldwide who are at increased risk of gynaecological malignancies.
Dilley, J, Gentry-Maharaj, A, Menon, U
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Molecular genetic approach for screening of hereditary non-polyposis colorectal cancer

Zdravniški Vestnik, 2005
Background: The main goal of knowledge concerning human diseases is to transfer as much as possible useful information into clinical applications.
Metka Ravnik-Glavač
doaj  

Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients

Journal of Experimental & Clinical Cancer Research, 2008
Background Patients with hereditary non-poliposys colorectal cancer (HNPCC) have better prognosis than sporadic colorectal cancer (CRC). Aim of our retrospective study was to compare the overall survival between sporadic CRC and HNPCC patients.
Mete Lupe, Mottolese Marcella, Giannarelli Diana, Palmirotta Raffaele, Cosimelli Maurizio, Assisi Daniela, Stigliano Vittoria, Mancini Raffaello, Casale Vincenzo   +8 more
doaj   +1 more source

Deficient DNA mismatch repair and persistence of SARS-CoV-2 RNA shedding: a case report of hereditary nonpolyposis colorectal cancer with COVID-19 infection. [PDF]

BMC Infect Dis, 2021
Haque F, Lillie P, Haque F, Maraveyas A.
europepmc   +1 more source

Cancer genetics in oncology practice [PDF]

, 2017
Cancer is a genetic disease caused by the progressive accumulation of mutations in critical genes that control cell growth and differentiation. Completion of the Human Genome Project promises to revolutionize the practice of Medicine, especially Oncology
Olopade, O. I., Pichert, G.
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