Results 21 to 30 of about 16,165 (220)

A novel nonsense mutation of MSH2 gene in a Taiwanese family with hereditary nonpolyposis colorectal cancer

Kaohsiung Journal of Medical Sciences, 2011
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant inherited disease predisposing to the development of colorectal cancers and several other malignancies (endometrium, ovaries, stomach, small bowel, hepatobiliary, and urinary ...
Wen-Chau Chen, Shao-Chieh Lin, Jenq-Chang Lee, 陳文超, 林劭潔, 李政昌   +5 more
doaj   +1 more source

Annual outpatient hysteroscopy and endometrial sampling (OHES) in HNPCC/Lynch syndrome (LS) [PDF]

, 2012
Background: LS women have a 40-60 % lifetime risk of endometrial cancer (EC). Most international guidelines recommend screening. However, data on efficacy are limited.
Adam N. Rosenthal, Ahmed Abdelraheim, C Gulumser, C Kremer, Carol Brunell, CL Trimble, E Saridogan, EB Pasqualotto, Elizabeth Benjamin, Ertan Saridogan, F Lecuru, F Lecuru, FE Rijcken, FP Dijkhuizen, HF Vasen, HF Vasen, HF Vasen, HF Vasen, I Dove-Edwin, I Jacobs, Ian Jacobs, JK Gupta, JV Lacey Jr, K Chu, K Elmasry, K Kerlikowske, L Renkonen-Sinisalo, LH Gerritzen, Lucy Side, M Aarnio, M Dimitraki, Michelle Johnson, MM Tahir, NJ Wood, NM Lindor, NP Baxter, Ranjit Manchanda, RJ Zaino, RR Broaddus, Sue Gessler, TJ Clark, Usha Menon, YM Hendriks, YM Hendriks   +43 more
core   +1 more source

Differential diagnosis of small bowel occlusions

Clinical Management Issues, 2009
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, and microsatellite instability (MSI).
Paolo Ghiringhelli
doaj   +1 more source

A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2. [PDF]

, 2018
BACKGROUND: Variation in an individual\u27s genetic status can impact the development of pancreatic ductal adenocarcinoma; however, the majority of familial pancreatic cancers (FPC) cannot yet be attributed to a specific inherited mutation.
Brody, Jonathan, Cozzitorto, Joseph A., Goetz, Austin, Lavu, Harish, Muller, Alexander J., Nevler, Avinoam, Prendergast, George C., Winter, Jordan M., Yeo, Charles, Yeo, Theresa P.   +9 more
core   +2 more sources

HISTORY OF HEREDITARY NONPOLYPOSIS COLORECTAL CANCER OR “LYNCH SYNDROME”

Revista Médica Clínica Las Condes, 2017
Hereditary Nonpolyposis Colorectal Cancer (HNPCC or “Lynch syndrome”), involving pathogenic variants in the Mismatch Repair (MMR) genes, is the most common inherited condition that predisposed to colorectal adenomas and colorectal cancer. In this chapter
Patrick M Lynch, JD, MD
doaj   +1 more source

Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature

Frontiers in Oncology, 2022
It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist ...
Adewale Adeoba Ayeni, Peter Waterland, Matthew Evans, Shika Singhal, Rajan Kumar Patel, Akinfemi Akingboye   +5 more
doaj   +1 more source

Historical review of Lynch syndrome

Journal of Coloproctology, 2013
Lynch syndrome was formerly known as Hereditary Nonpolyposis Colorectal Cancer. Currently, these two nomenclatures each have their unique definitions and are no longer used interchangeably.
Andrew I. Wolf, Adam H. Buchanan, Linda M. Farkas   +2 more
doaj   +1 more source

Distress, anxiety, and depression in persons with hereditary cancer syndromes: Results from a nationwide cross‐sectional study in Germany

Cancer Medicine, 2023
Background Persons with hereditary cancer syndromes (carriers) have a higher risk of developing cancer early. They are confronted with decisions regarding prophylactic surgeries, communication within their families, and childbearing.
Anna Maria Kastner, Josefine Fischer‐Jacobs, Jan Brederecke, Andrea Hahne, Tanja Zimmermann   +4 more
doaj   +1 more source

Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)

Revista de la Facultad de Medicina, 2016
Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer.
David Serrano, Clara Eugenia Arteaga
doaj   +1 more source

A comprehensive custom panel evaluation for routine hereditary cancer testing: improving the yield of germline mutation detection

Journal of Translational Medicine, 2020
Background In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management.
Carolina Velázquez, Enrique Lastra, Francisco Avila Cobos, Luis Abella, Virginia de la Cruz, Blanca Ascensión Hernando, Lara Hernández, Noemí Martínez, Mar Infante, Mercedes Durán   +9 more
doaj   +1 more source