Results 41 to 50 of about 16,165 (220)

A Review on Image Processing and Fractal Analysis in Oral Potentially Malignant Disorders

Oral Diseases, EarlyView.
ABSTRACT Aim The clinical evaluation of patients with oral potentially malignant disorders is primarily based on physical examination and observable clinical features. Clinical photographs play a key role in patient monitoring and help identify signs that may indicate malignant transformation.
André Goulart Poletto, Flaviana Silva de Souza, Lilian Bezerra, Thiago Pires Claudio, Jesse Parente Tocantins, Helena Miguel Cotter, Riéli Elis Schulz, Karin Berria Tomazelli, Elena Riet Correa Rivero, Fabio Luiz Coracin, Gustavo Davi Rabelo   +10 more
wiley   +1 more source

N‐terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα [PDF]

, 2006
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and hMutLα (hMLH1‐hPMS2) constitute the centre of the repair reaction ...
Brieger, Angela, Plotz, Guido, Raedle, Jochen, Trojan, Jörg, Zeuzem, Stefan   +4 more
core  

Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 895-913, March 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancers, typically diagnosed at an advanced stage due to its subtle and often absent early symptoms. Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer‐related deaths by 2030.
Muhammad Masroor Hussain, Sana Qammar, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source

Hereditary Colorectal Cancer in China

Hereditary Cancer in Clinical Practice, 2005
The purpose of this article is to review basic research as well as clinical studies on Chinese hereditary colorectal cancer. Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) accounts for 2.2% of all colorectal cancer, and Chinese ...
Shu Zheng, Yanqin Huang, Ying Yuan
doaj   +1 more source

Investigating the Link between Lynch Syndrome and Breast Cancer

European Journal of Breast Health, 2020
Objective:Lynch syndrome is an inherited genetic disorder associated with a predisposition to early-onset colorectal and endometrial cancers, but breast cancer risk in these patients is debated. The aim of this study is to evaluate breast cancer rates in
Megan Sheehan, Brandie Heald, Courtney Yanda, Erinn Downs Kelly, Stephen Grobmyer, Charis Eng, Matthew Kalady, Holly Pederson   +7 more
doaj   +1 more source

Patient‐Reported‐Outcome‐Measures (PROMs) After Gastrointestinal Endoscopic Resections

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Data on patient‐reported outcome measures (PROMs) of patients undergoing endoscopic resections have been sparse. The aim of our study was the prospective assessment of the Gastrointestinal Quality of Life Index (GIQLI) as a baseline and post‐endoscopic resection (ER) measurement in patients with epithelial mucosal neoplasms ...
Laura Retzbach, Karl‐Hermann Fuchs, Markus Brand, Thomas J. Lux, Alexander Meining   +4 more
wiley   +1 more source

Penetrance of colorectal cancer among / carriers participating in the colorectal cancer familial registry in Ontario [PDF]

, 2009
Background Several DNA mismatch repair (MMR) genes, responsible for the majority of Lynch Syndrome cancers, have been identified, predominantly MLH1 and MSH2, but the risk associated with these mutations is still not well established. The
Yun-Hee Choi, Michelle Cotterchio, Gail McKeown-Eyssen, Monga Neerav, Bharati Bapat, Kevin Boyd, Steven Gallinger, John McLaughlin, Melyssa Aronson, Laurent Briollais, HT Lynch, T Bocker, M Aarnio, KM Lin, HFA Vasen, MG Dunlop, M Cotterchio, MG Dunlop, MO Woods, EL Kaplan, CR Boland, BV Bapat, JP Schouten, V Ramensky, PC Ng, P Kraft, YH Choi, MA Jenkins, K Lange, F Quehenberger, J Green, M Aarnio, NJ Froggart, HFA Vasen, Y Parc, H Hampel, HFA Vasen, CB Begg, J Carayol, B Theis   +39 more
core   +2 more sources

Urothelial carcinoma: Perioperative considerations from top to bottom

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 528-551, November/December 2025.
Abstract Urothelial carcinoma is an aggressive entity that is associated with significant morbidity, but there have been major advances in both our understanding of and treatment options for patients with this disease. In this review, the authors focus on novel therapeutic and diagnostic approaches in the perioperative setting, with an emphasis on ...
Wesley Yip, Salvador Jaime‐Casas, Anjaney Kothari, Mary Sullivan, Leslie K. Ballas, Domenique Escobar, Anne K. Schuckman, Jonathan E. Rosenberg, Jonathan A. Coleman   +8 more
wiley   +1 more source

Attitudes Toward Updated Genetic Testing Among Patients with Unexplained Mismatch Repair Deficiency [PDF]

, 2018
Individuals who have colorectal cancer (CRC) or endometrial cancer (EC) displaying loss of immunohistochemical (IHC) staining of one or more mismatch repair (MMR) proteins without a causative germline mutation are said to have unexplained mismatch repair
Omark, Jessica
core   +1 more source

Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study

Cancer Communications, Volume 45, Issue 11, Page 1407-1416, November 2025.
Abstract Background The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early‐onset CRC
Yuqing Hu, Elham Kharazmi, Qunfeng Liang, Hermann Brenner, Jan Sundquist, Kristina Sundquist, Mahdi Fallah   +6 more
wiley   +1 more source