Results 41 to 50 of about 16,515 (221)

Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation [PDF]

, 2017
This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC ...
Aarnio, Ahadova, Arends, Balmana, Barnetson, Barrow, Barrow, Barrow, Barzi, Boland, Bonadona, Bonis, Bouzourene, Bowel Cancer UK, Burn, Cairns, Caldes, Calvert, Cancer Research, Cancer Research UK, Cancer Research UK, Centre for Reviews and Dissemination, Chang, Chen, Colling, Commercial Medicines Unit, Curtis, Curtis, Cuzick, de Boer, Department of Health, Desouza, Dietmaier, Dineen, Dinh, Doble, Dolan, Domingo, Dove-Edwin, Drummond, East of Scotland Regional Genetic Service, Eccleston, Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group, Evers, Fajobi, Ferrandina, Finan, Frayling, Färkkilä, Gallego, Gallego, Gallego, Gavin, George, Giardiello, Goker, Goldstein, Great Britain, Grosse, Haanstra, Hall, Hampel, Hampel, Hanly, Haraldsdottir, Haraldsdottir, Havrilesky, Hendriks, Hildebrandt, Hornbrook, Hung, Ibrahim, Janus, Jenkins, John, Joint Formulary Committee, Järvinen, Järvinen, Kalady, Kaur, Kempers, Kloor, Kuppermann, Labianca, Ladabaum, Ladabaum, Le, Lewin, Ligtenberg, Lijmer, Limburg, Lin, Longworth, Loughrey, Lynch, Maeda, Mecklin, Mhaidat, Mittmann, Moher, Morak, Mueller, Mulder, Munoz, Mvundura, Møller, Møller, National Cancer Intelligence Network, National Cancer Intelligence Network, National Comprehensive Cancer Network, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, Ness, Newton, NHS, NHS Prescription Services, Niessen, Niv, Nout, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Okkels, Overbeek, Overbeek, Palomaki, Pande, Parsons, Pawlik, Peninsula Technology Assessment Group (PenTAG), Philips, Pollett, Poulogiannis, Poynter, Ramsey, Ramsey, Ransohoff, Renkonen-Sinisalo, Sacco, Schmeler, Schnell, Senter, Severin, Sharp, Shia, Shlien, Sjursen, Sjursen, Slade, Snowsill, Snowsill, Southey, Stein, Sundar, The Stationery Office, Thompson, Thong, Trueman, UK Genetic Testing Network, Umar, US National Library of Medicine, Vasen, Vasen, Vasen, Vasen, Veysey, Wang, Ward, Webber, Welsh Cancer Intelligence and Surveillance Unit, Whiting, Whiting, Whiting, Wong, Wong, Wong, Zhang   +193 more
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Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study

Cancer Communications, Volume 45, Issue 11, Page 1407-1416, November 2025.
Abstract Background The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early‐onset CRC
Yuqing Hu, Elham Kharazmi, Qunfeng Liang, Hermann Brenner, Jan Sundquist, Kristina Sundquist, Mahdi Fallah   +6 more
wiley   +1 more source

Hereditary Colorectal Cancer in China

Hereditary Cancer in Clinical Practice, 2005
The purpose of this article is to review basic research as well as clinical studies on Chinese hereditary colorectal cancer. Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) accounts for 2.2% of all colorectal cancer, and Chinese ...
Shu Zheng, Yanqin Huang, Ying Yuan
doaj   +1 more source

Investigating the Link between Lynch Syndrome and Breast Cancer

European Journal of Breast Health, 2020
Objective:Lynch syndrome is an inherited genetic disorder associated with a predisposition to early-onset colorectal and endometrial cancers, but breast cancer risk in these patients is debated. The aim of this study is to evaluate breast cancer rates in
Megan Sheehan, Brandie Heald, Courtney Yanda, Erinn Downs Kelly, Stephen Grobmyer, Charis Eng, Matthew Kalady, Holly Pederson   +7 more
doaj   +1 more source

N‐terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα [PDF]

, 2006
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and hMutLα (hMLH1‐hPMS2) constitute the centre of the repair reaction ...
Brieger, Angela, Plotz, Guido, Raedle, Jochen, Trojan, Jörg, Zeuzem, Stefan   +4 more
core  

Inaccuracy of Ureteroscopic Biopsy in Upper Tract Urothelial Carcinoma Can Lead to False Therapeutic Decisions: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Do not rely solely on negative endoscopic biopsies when diagnosing upper tract urothelial carcinoma (UTUC). Repeat ureteroscopy with biopsy if initial results are negative to reduce false negatives. Frozen section analysis (FSA) can provide rapid intraoperative confirmation and guide treatment decisions.
Ayoub Hidayat‐Allah, Frank Friedersdorff   +1 more
wiley   +1 more source

A rare case of colonic adenocarcinoma in a pediatric patient

JPGN Reports, Volume 6, Issue 4, Page 400-403, November 2025.
Abstract Lynch syndrome (LS) is an autosomal dominant condition caused by a loss of function in the deoxyribonucleic acid mismatch repair system. This case report presents a 17‐year‐old male with abdominal pain, weight loss, and anemia who was diagnosed with LS‐associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation ...
Christine Kaba, Kelsey Chatman, Nicole Hames, Jose E. Velazquez Vega, Hillary Bashaw   +4 more
wiley   +1 more source

Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation [PDF]

, 2018
Lynch syndrome is one of the most common hereditary colorectal cancer (CRC) syndrome and is caused by germline mutations of MLH1, MSH2 and more rarely MSH6, PMS2, MLH3 genes.
Benhattar, Jean, Bouzourene, Hanifa, Hutter, Pierre, Losi, Lorena, Martin, Patricia   +4 more
core  

Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome

Dermatology Research and Practice, 2010
Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS).
Michael C. Lynch, Bryan E. Anderson
doaj   +1 more source

MT1XT20 single quasi-monomorphic mononucleotide marker for detection of microsatellite instability in iranian patients with hereditary nonpolyposis colorectal cancer (HNPCC) [PDF]

, 2016
Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary or sporadic, demonstrate better prognosis, altered response to fluorouracil (5FU) chemotherapy and altered operative approach.
Emami, Mohammad Hassan., Farahani, Najmeh., Hashemzadeh-Chaleshtori, Morteza., Nikpour, Parvaneh., Salehi, Rasoul., Zeinalian, Mehrdad.   +5 more
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