Evaluation of MT1XT20 single quasi-monomorphic mononucleotide marker for characterizing microsatellite instability in persian lynch syndrome patients [PDF]
, 2016 Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy.
Emami, Mohammad Hassan. +6 more
core
The Journal of Pathology, Volume 265, Issue 1, Page 14-25, January 2025.Abstract Secretomes of cancer‐associated fibroblasts (CAFs) in colorectal cancer (CRC) contribute to malignancy. Detailed knowledge is available on the components and functions of CAF secretomes. Little is known about the regulation of CAF secretomes.
Yongsong Yong +13 more
wiley +1 more source
Functional Characterization of MutS Homologue Mismatch Repair Proteins and their Variants [PDF]
, 2012 Lynch syndrome (LS) is one of the most common hereditary cancer syndromes and may lead to cancer development, mainly in colon or in endometrium, for 20 years earlier than in general population. LS is an autosomal dominantly inherited disorder, associated
Kantelinen, Jukka Petteri
core
Lynch Syndrome from a surgeon perspective: retrospective study of clinical impact of mismatch repair protein expression analysis in colorectal cancer patients less than 50 years old. [PDF]
, 2014 BACKGROUND: In clinical practice, unexpected diagnosis of colorectal cancer in young patients requires prompt surgery, thus genetic testing for Lynch Syndrome is frequently missed, and clinical management may result incorrect.
Baiocchi GL +9 more
core +1 more source
Exploring the Common Mutational Landscape in Cutaneous Melanoma and Pancreatic Cancer
Pigment Cell &Melanoma Research, Volume 38, Issue 1, January 2025.ABSTRACT Cutaneous melanoma (CM) and pancreatic cancer are aggressive tumors whose incidences are rapidly increasing in the last years. This review aims to provide a complete and update description about mutational landscape in CM and pancreatic cancer, focusing on similarities of these two apparently so different tumors in terms of site, type of cell ...
Elisabetta Broseghini +9 more
wiley +1 more source
HEREDITARY NON-POLYPOSIS COLORECTAL CANCER (LYNCH SYNDROME) PADA WANITA UMUR 16 TAHUN
Majalah Kedokteran Andalas, 2011 AbstrakKanker kolorektal menduduki peringkat ketiga jenis kanker yang paling sering terjadi di dunia. Sekitar 3% kasus kanker kolorektal merupakan jenis hereditary non polyposis colorectal cancer (HNPCC)/Lynch syndrome, yang sering muncul pada usia muda.
Asril Zahari, Sudiyatmo Sudiyatmo
doaj +1 more source
Familial colorectal cancer: eleven years of data from a registry program in Switzerland [PDF]
, 2018 Deleterious germ-line variants involving the DNA mismatch repair (MMR) genes have been identified as the cause of the hereditary nonpolyposis colorectal cancer syndrome known as the Lynch syndrome, but in numerous familial clusters of colon cancer, the ...
Haider, Ritva +6 more
core
A model-based assessment of the cost-utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients. [PDF]
, 2015 This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Lynch syndrome is an autosomal dominant cancer predisposition syndrome caused by mutations in the DNA ...
Coelho, H +7 more
core +2 more sources
Hereditary Cancer in Clinical Practice, 2019 Background Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in expert centres.
Toni T. Seppälä +56 more
doaj +1 more source
Reduced expression of alanyl aminopeptidase is a robust biomarker of non-familial adenomatous polyposis and non-hereditary nonpolyposis colorectal cancer syndrome early-onset colorectal cancer. [PDF]
Cancer Med, 2023 Ha YJ +9 more
europepmc +1 more source