Results 1 to 10 of about 33,807 (258)
An Update on the Structure of hERG [PDF]
Frontiers in Pharmacology, 2020 The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action potential repolarization, effectively controlling the QT interval of the electrocardiogram.
A. Butler +4 more
semanticscholar +7 more sources
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
Cell, 1995 Mark Curran +5 more
openalex +2 more sources
Psychotropic drugs, HERG, and the heart [PDF]
The Lancet, 2000 JC Hancox, HJ Witchel
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Frontiers in Pharmacology, 2022 Drug-induced cardiotoxicity is a common side effect of drugs in clinical use or under postmarket surveillance and is commonly due to off-target interactions with the cardiac human-ether-a-go-go-related (hERG) potassium channel.
Pietro Delre +7 more
semanticscholar +1 more source
High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition
Biology, 2022 Simple Summary Cardiovascular disease is the leading cause of death for people of most ethnicities in the United States. The human ether-a-go-go-related gene (hERG) potassium channel plays a pivotal role in cardiac rhythm regulation, and cardiotoxicity ...
Shagun Krishna +5 more
semanticscholar +1 more source
Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study
Journal of Chemical Information and Modeling, 2021 Drug-induced blockade of the human ether-à-go-go-related gene (hERG) channel is today considered the main cause of cardiotoxicity in postmarketing surveillance.
T. Creanza +5 more
semanticscholar +1 more source
Journal of Cheminformatics, 2021 Motivation Ether-a-go-go-related gene (hERG) channel blockade by small molecules is a big concern during drug development in the pharmaceutical industry.
Abdul Karim +3 more
semanticscholar +1 more source
Biophysical Journal, 2011 HERG (Kv11.1, KCNH2) is a voltage-gated potassium channel with unique gating characteristics. HERG has fast voltage-dependent inactivation, relatively slow deactivation, and fast recovery from inactivation. This combination of gating kinetics makes study of HERG difficult without using mathematical models.
Glenna C.L. Bett +2 more
openaire +3 more sources
Mechanism of C-type inactivation in the hERG potassium channel
Science Advances, 2021 C-type inactivation in hERG is associated with an asymmetrical constricted-like conformation of the selectivity filter. The fast C-type inactivation displayed by the voltage-activated potassium channel hERG plays a critical role in the repolarization of ...
Jing Li +4 more
semanticscholar +1 more source
Investigation of the Influence of hERG 1b on hERG Channel Pharmacology [PDF]
Biophysical Journal, 2013 hERG channels mediating the rapid delayed rectifier K+ current (IKr) are important for normal ventricular repolarization. In native cardiac tissues, hERG 1a subunit co-assembles with a subunit encoded by an alternate transcript, “ERG1b” which has a shorter N-terminus (1) and influences current kinetics (2).
Aziza El Harchi +2 more
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