Results 31 to 40 of about 33,807 (258)
Kv4.3 Modulates the Distribution of hERG [PDF]
Scientific Reports, 2017 AbstractThis study examines the interaction between hERG and Kv4.3. The functional interaction between hERG and Kv4.3, expressed in a heterologous cell line, was studied using patch clamp techniques, western blot, immunofluorescence, and co-immunoprecipitation.
Xi Chen +7 more
openaire +2 more sources
The Study on the hERG Blocker Prediction Using Chemical Fingerprint Analysis
Molecules, 2020 Human ether-a-go-go-related gene (hERG) potassium channel blockage by small molecules may cause severe cardiac side effects. Thus, it is crucial to screen compounds for activity on the hERG channels early in the drug discovery process.
Kwang-Eun Choi, A. Balupuri, N. Kang
semanticscholar +1 more source
Antipsychotics, HERG and sudden death [PDF]
British Journal of Psychiatry, 2003 The recent case—control study by Reilly et al ([2002][1]) showing an association between probable sudden unexplained death and current treatment with thioridazine in psychiatric in-patients underscores two fundamental issues essential for dealing with potential risks of this kind in the context ...
Jules C. Hancox +3 more
openaire +2 more sources
Computational determination of hERG-related cardiotoxicity of drug candidates
BMC Bioinformatics, 2019 Drug candidates often cause an unwanted blockage of the potassium ion channel of the human ether-a-go-go-related gene (hERG). The blockage leads to long QT syndrome (LQTS), which is a severe life-threatening cardiac side effect.
Hyang-Mi Lee +11 more
semanticscholar +1 more source
The Large Area Radio Galaxy Evolution Spectroscopic Survey (LARGESS): survey design, data catalogue and GAMA/WiggleZ spectroscopy [PDF]
, 2016 © 2016 The Authors. We present the Large Area Radio Galaxy Evolution Spectroscopic Survey (LARGESS), a spectroscopic catalogue of radio sources designed to include the full range of radio AGN populations out to redshift z ~ 0.8. The catalogue covers ~800
Ching, John H.Y. +8 more
core +2 more sources
Modulation of hERG K+ Channel Deactivation by Voltage Sensor Relaxation
Frontiers in Pharmacology, 2020 The hERG (human-ether-à-go-go-related gene) channel underlies the rapid delayed rectifier current, Ikr, in the heart, which is essential for normal cardiac electrical activity and rhythm.
Y. Shi, S. Thouta, T. Claydon
semanticscholar +1 more source
Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A [PDF]
British Journal of Anaesthesia, 2004 Myocardial potassium channels are complexes formed by different subunits. The subunit composition may influence the cardiotoxic action of local anaesthetics. The effects of amide local anaesthetics on HERG channels co-expressed with the putative subunit MiRP1 have not been established.
Dirk Isbrandt +3 more
openaire +2 more sources
Conservation and specialization in PAS domain dynamics [PDF]
, 2005 The PAS (Per-ARNT-Sim) superfamily is presented as a well-suited study case to demonstrate how comparison of functional motions among distant homologous proteins with conserved fold characteristics may give insight into their functional specialization ...
Bonati, L, Pandini, A
core +2 more sources
Compact steep-spectrum sources as the parent population of flat-spectrum radio-loud NLS1s [PDF]
, 2016 Narrow-line Seyfert 1 galaxies (NLS1s) are an interesting subclass of active galactic nuclei (AGN), which tipically does not exhibit any strong radio emission.
Berton, Marco +11 more
core +2 more sources
bioRxiv, 2020 The human ether-a-go-go-related voltage-gated cardiac ion channel (commonly known as hERG) conducts the rapid outward repolarizing potassium current in cardiomyocytes (IKr).
Hongbin Wan, G. Selvaggio, R. Pearlstein
semanticscholar +1 more source