Results 31 to 40 of about 36,434 (294)

Models of HERG Gating [PDF]

Biophysical Journal, 2011
HERG (Kv11.1, KCNH2) is a voltage-gated potassium channel with unique gating characteristics. HERG has fast voltage-dependent inactivation, relatively slow deactivation, and fast recovery from inactivation. This combination of gating kinetics makes study of HERG difficult without using mathematical models.
Bett, Glenna C.L., Zhou, Qinlian, Rasmusson, Randall L.   +2 more
openaire   +2 more sources

Early Steps in C-Type Inactivation of the hERG Potassium Channel

Journal of Chemical Information and Modeling, 2022
Fast C-type inactivation confers distinctive functional properties to the hERG potassium channel, and its association to inherited and acquired cardiac arrythmias makes the study of the inactivation mechanism of hERG at the atomic detail of paramount ...
Francesco Pettini, C. Domene, S. Furini
semanticscholar   +1 more source

Homozygous Premature Truncation of the HERG Protein [PDF]

Circulation, 1999
Background —In long-QT syndrome (LQTS), heterozygosity for a mutation in 1 of the K + channel genes leads to prolongation of the cardiac action potential, because the aberrant protein exhibits “loss of function.” HERG, which is involved in LQT2, is the gene encoding the rapid component of the delayed ...
Hoorntje, T., Alders, M., van Tintelen, P., van der Lip, K., Sreeram, N., van der Wal, A., Mannens, M., Wilde, A.   +7 more
openaire   +4 more sources

The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031

Biomolecules, 2021
Inhibition of K+-conductance through the human ether-a-go-go related gene (hERG) channel leads to QT prolongation and is associated with cardiac arrhythmias.
Fumiya Tamura, Shintaro Sugimoto, Mana Sugimoto, Kazuho Sakamoto, Masahiko Yamaguchi, Takeshi Suzuki, Keiichi Fukuda, Masaki Ieda, Junko Kurokawa   +8 more
doaj   +1 more source

Prediction of hERG inhibition of drug discovery compounds using biomimetic HPLC measurements

ADMET and DMPK, 2021
The major causes of failure of drug discovery compounds in clinics are the lack of efficacy and toxicity. To reduce late-stage failures in the drug discovery process, it is essential to estimate early the probability of adverse effects and potential ...
Chrysanthos Stergiopoulos, Fotios Tsopelas, K. Valko   +2 more
semanticscholar   +1 more source

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. [PDF]

PLoS ONE, 2017
The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization.
Dahai Yu, Lin Lv, Li Fang, Bo Zhang, Junnan Wang, Ge Zhan, Lei Zhao, Xin Zhao, Baoxin Li   +8 more
doaj   +1 more source

miRNAs Regulate hERG [PDF]

Journal of Cardiovascular Electrophysiology, 2016
miRNAs Regulate hERGBackgroundThe human ether‐a‐go‐go‐related gene (hERG) is the major molecular component of the rapidly activating delayed rectifier K+ current (Ikr). Impairment of hERG function is believed to be a mechanism causing long‐QT syndromes (LQTS). Growing evidences have shown that microRNAs (miRNAs) are involved in functional modulation of
Jiangfang, Lian, Jian, Guo, Xiaoyan, Huang, X I, Yang, Guochang, Huang, Haiyan, Mao, Huan Huan, Sun, Yanna, Ba, Jianqing, Zhou   +8 more
openaire   +2 more sources

Mechanism of C-type inactivation in the hERG potassium channel

Science Advances, 2021
C-type inactivation in hERG is associated with an asymmetrical constricted-like conformation of the selectivity filter. The fast C-type inactivation displayed by the voltage-activated potassium channel hERG plays a critical role in the repolarization of ...
Jing Li, R. Shen, B. Reddy, E. Perozo, B. Roux   +4 more
semanticscholar   +1 more source

hERG-deficient human embryonic stem cell-derived cardiomyocytes for modelling QT prolongation

Stem Cell Research & Therapy, 2021
Background Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear.
Yun Chang, Ya-nan Li, Rui Bai, Fujian Wu, Shuhong Ma, Amina Saleem, Siyao Zhang, Youxu Jiang, Tao Dong, Tianwei Guo, Chengwen Hang, Wen-jing Lu, Hongfeng Jiang, Feng Lan   +13 more
doaj   +1 more source

hERG Function in Light of Structure [PDF]

Biophysical Journal, 2020
The human ether-a-go-go-related gene1 (hERG) ion channel has been the subject of fascination since it was identified as a target of long QT syndrome more than 20 years ago. In this Biophysical Perspective, we look at what makes hERG intriguing and vexingly unique. By probing recent high-resolution structures in the context of functional and biochemical
Gail A, Robertson, João H, Morais-Cabral   +1 more
openaire   +2 more sources