Results 41 to 50 of about 36,434 (294)

Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. [PDF]

PLoS ONE, 2013
Treatment of LQT2 is inadequate. Many drugs which can pharmacologically rescue defective protein trafficking in LQT2 also result in potent blockade of HERG current, negating their therapeutic benefit.
Haiyan Mao, Xiaoli Lu, Justin Michael Karush, Xiaoyan Huang, Xi Yang, Yanna Ba, Ying Wang, Ningsheng Liu, Jianqing Zhou, Jiangfang Lian   +9 more
doaj   +1 more source

The triggering probability of radio-loud AGN: A comparison of high and low excitation radio galaxies in hosts of different colors [PDF]

, 2012
Low luminosity radio-loud active galactic nuclei (AGN) are generally found in massive red elliptical galaxies, where they are thought to be powered through gas accretion from their surrounding hot halos in a radiatively inefficient manner.
Abazajian, Baldwin, Balogh, Becker, Best, Best, Best, Best, Brinchmann, Condon, Croton, Evans, H. J. A. Röttgering, Hardcastle, Hickox, J. Brinchmann, Kauffmann, Kauffmann, Kauffmann, Martin, Matthews, P. N. Best, R. M. J. Janssen, Schmidt, Stoughton, Strateva, Strauss, Tadhunter, Tasse, Whysong, York   +30 more
core   +3 more sources

Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

Cellular and Molecular Life Sciences, 2021
The lipophilic polycyclic aromatic hydrocarbon (PAH) phenanthrene is relatively abundant in polluted air and water and can access and accumulate in human tissue. Phenanthrene has been reported to interact with cardiac ion channels in several fish species.
Ehab Al-Moubarak, H. Shiels, Yihong Zhang, C. Du, O. Hanington, S. Harmer, C. Dempsey, J. Hancox   +7 more
semanticscholar   +1 more source

Investigation of the Influence of hERG 1b on hERG Channel Pharmacology [PDF]

Biophysical Journal, 2013
hERG channels mediating the rapid delayed rectifier K+ current (IKr) are important for normal ventricular repolarization. In native cardiac tissues, hERG 1a subunit co-assembles with a subunit encoded by an alternate transcript, “ERG1b” which has a shorter N-terminus (1) and influences current kinetics (2).
El Harchi, Aziza, Melgari, Dario, Hancox, Jules C.   +2 more
openaire   +1 more source

Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel.

PLoS ONE, 2012
BackgroundThe familial Short QT Syndrome (SQTS) is associated with an increased risk of cardiac arrhythmia and sudden death. Gain-of-function mutations in the hERG K(+) channel protein have been linked to variant 1 of the SQTS. A hERG channel pore (T618I)
Aziza El Harchi, Dario Melgari, Yi Hong Zhang, Henggui Zhang, Jules C Hancox   +4 more
doaj   +1 more source

Calculations of the binding free energies of the Comprehensive in vitro Proarrhythmia Assay (CiPA) reference drugs to cardiac ion channels

Biophysics and Physicobiology, 2023
The evaluation of the inhibitory activities of drugs on multiple cardiac ion channels is required for the accurate assessment of proarrhythmic risks.
Tatsuki Negami, Tohru Terada
doaj   +1 more source

The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line. [PDF]

, 2011
The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death.
Anish Bali, Asher, Viren, Averil Warren, Heidi Sowter, Raheela Khan, Robert Shaw, Viren Asher   +6 more
core   +5 more sources

Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum. [PDF]

PLoS ONE, 2012
Long QT syndrome type 2 (LQT2) is the second most common type of all long QT syndromes. It is well-known that trafficking deficient mutant human ether-a-go-go-related gene (hERG) proteins are often involved in LQT2.
Ying Wang, Xiaoyan Huang, Jianqing Zhou, Xi Yang, Di Li, Haiyan Mao, Huan Huan Sun, Ningsheng Liu, Jiangfang Lian   +8 more
doaj   +1 more source

Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia

Journal of Cellular and Molecular Medicine, 2021
Drug‐mediated or medical condition‐mediated disruption of hERG function accounts for the main cause of acquired long‐QT syndrome (acLQTs), which predisposes affected individuals to ventricular arrhythmias (VA) and sudden death.
G. Zhan, Fang Wang, Yunqi Ding, Xiang-hua Li, Yue-xin Li, Zheng-Rong Zhao, Jiaxin Li, Yan Liu, Xin Zhao, Caichuan Yan, Bao-Xin Li   +10 more
semanticscholar   +1 more source

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]

, 2016
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia, Brock, Mathew, Chan, Dulciana, Chvatal, Stacie, Crumb, William J., Galeotti, Loriano, Hortigon-Vinagre, Maria P., Johannesen, Lars, Lyn-Cook, Beverly, Millard, Daniel, Pang, Li, Ross, James, Smith, Godfrey, Stockbridge, Norman, Stohlman, Jayna, Strauss, David G., Vicente, Jose, Zamora Rodriguez, Victor   +17 more
core   +1 more source