Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance. [PDF]
EMBO JFellas A +5 more
europepmc +3 more sources
Epigenetics & Chromatin, 2022 Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an ortholog of mammalian HP1, lead to heterochromatin formation. However, S.
Junsoo Oh +3 more
doaj +1 more source
Global regulation of heterochromatin spreading by Leo1 [PDF]
Open Biology, 2015 Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries ...
Laure Verrier +6 more
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Heterochromatin revisited [PDF]
Nature Reviews Genetics, 2007 The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome.
Shiv I S, Grewal, Songtao, Jia
openaire +2 more sources
Constitutive Heterochromatin in Eukaryotic Genomes: A Mine of Transposable Elements
Cells, 2022 Transposable elements (TEs) are abundant components of constitutive heterochromatin of the most diverse evolutionarily distant organisms. TEs enrichment in constitutive heterochromatin was originally described in the model organism Drosophila ...
René Massimiliano Marsano +1 more
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The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast. [PDF]
PLoS Genetics, 2014 Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation.
Scott P Kallgren +8 more
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Different behaviour of C-banded peri-centromeric heterochromatin between sex chromosomes and autosomes in Polyphagan beetles [PDF]
Comparative Cytogenetics, 2019 Heterochromatin variation was studied after C-banding of male karyotypes with a XY sex formula from 224 species belonging to most of the main families of Coleoptera.
Anne-Marie Dutrillaux +1 more
doaj +3 more sources
DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks
Frontiers in Genetics, 2021 In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin marks and associated factors in shaping DSB repair ...
Pierre Caron +2 more
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Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]
, 2020 Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David +7 more
core +3 more sources
Maternal depletion of Piwi, a component of the RNAi system, impacts heterochromatin formation in Drosophila. [PDF]
PLoS Genetics, 2013 A persistent question in epigenetics is how heterochromatin is targeted for assembly at specific domains, and how that chromatin state is faithfully transmitted.
Tingting Gu, Sarah C R Elgin
doaj +1 more source