Results 1 to 10 of about 124,493 (360)
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. [PDF]
Nature, 2017 Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
Agard, David A +8 more
core +2 more sources
Heterochromatin: Guardian of the Genome. [PDF]
Annual Review of Cell and Developmental Biology, 2018 Constitutive heterochromatin is a major component of the eukaryotic nucleus and is essential for the maintenance of genome stability. Highly concentrated at pericentromeric and telomeric domains, heterochromatin is riddled with repetitive sequences and ...
A. Janssen +2 more
semanticscholar +5 more sources
Establishment and evolution of heterochromatin [PDF]
Annals of the New York Academy of Sciences, 2020 The eukaryotic genome is packaged into transcriptionally active euchromatin and silent heterochromatin, with most studies focused on the former encompassing the majority of protein‐coding genes. The recent development of various sequencing techniques has
Jing Liu, Mujahid Ali, Qi Zhou
semanticscholar +4 more sources
The Cell Biology of Heterochromatin
Cells, 2022 A conserved feature of virtually all higher eukaryotes is that the centromeres are embedded in heterochromatin. Here we provide evidence that this tight association between pericentric heterochromatin and the centromere is essential for proper metaphase exit and progression into telophase. Analysis of chromosome rearrangements that separate pericentric
Brandt Warecki, William Sullivan
openaire +4 more sources
Heterochromatin and nucleic acid
Agricultural and Food Science, 1948 Heterokromaattisiksi tämän käsitteen laajimmassa merkityksessä on nimitetty kromosominosia, jotka spiraloitumiseensa ja värjäytyväisyyteensä nähden jossain tuman vaiheessa eroavat muista, eukromaattisista kromosominosista. Heterokromatiini, sen rakenne ja toiminta, ovat erikoisesti viimeisen kymmenen vuoden aikana olleet vilkkaan tutkimuksen kohteena ...
Eeva Therman-Suomalainen
openalex +5 more sources
Nature reviews. Molecular cell biology, 2022 Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes, where it ensures their transcriptional silencing.
Jan Padeken +2 more
semanticscholar +1 more source
53BP1 regulates heterochromatin through liquid phase separation
Nature Communications, 2022 Human 53BP1 is primarily known as a key player in regulating DNA double strand break (DSB) repair choice; however, its involvement in other biological process is less well understood.
Lei Zhang +18 more
semanticscholar +1 more source
SIRT3 consolidates heterochromatin and counteracts senescence
Nucleic Acids Research, 2021 Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear. Here
Zhiqing Diao +15 more
semanticscholar +1 more source
Heterochromatin: silence is golden [PDF]
Current Biology, 2003 Epigenetically heritable heterochromatin domains control a variety of chromosomal functions. In addition to stable repression of large pericentric and telomeric domains, heterochromatin plays an essential role in the maintenance of genomic integrity through its role in sister chromatin cohesion and chromosome segregation.
Shiv I. S. Grewal, Sarah C. R. Elgin
openaire +3 more sources
Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]
, 2020 Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David +7 more
core +2 more sources