A computational model for histone mark propagation reproduces the distribution of heterochromatin in different human cell types [PDF]
PLoS ONE 8(9): e73818, 2013 Chromatin is a highly compact and dynamic nuclear structure that consists of DNA and associated proteins. The main organizational unit is the nucleosome, which consists of a histone octamer with DNA wrapped around it. Histone proteins are implicated in the regulation of eukaryote genes and they carry numerous reversible post-translational modifications
Jensen, Ole Nørregaard +1 more
arxiv +16 more sources
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation [PDF]
Epigenetics & ChromatinBackground Heterochromatin is a fundamental component of eukaryotic chromosome architecture, crucial for genome stability and cell type-specific gene regulation.
Kei Fukuda +2 more
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Fission yeast Caprin protein is required for efficient heterochromatin establishment. [PDF]
PLoS GeneticsHeterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving ...
Haidao Zhang +5 more
doaj +2 more sources
The nuclear poly(A)-binding protein Pab2/PABPN1 promotes heterochromatin assembly through the formation of Pab2 nuclear condensates. [PDF]
PLoS GeneticsThe assembly of constitutive heterochromatin is a prerequisite for maintaining genome stability. However, the mechanism of heterochromatin formation has yet to be completely understood.
Ziyue Liu +3 more
doaj +2 more sources
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair [PDF]
Nature CommunicationsThe CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown.
Feng Li +8 more
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Epigenetics & Chromatin, 2022 Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an ortholog of mammalian HP1, lead to heterochromatin formation. However, S.
Junsoo Oh +3 more
doaj +1 more source
Global regulation of heterochromatin spreading by Leo1 [PDF]
Open Biology, 2015 Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries ...
Laure Verrier +6 more
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Constitutive Heterochromatin in Eukaryotic Genomes: A Mine of Transposable Elements
Cells, 2022 Transposable elements (TEs) are abundant components of constitutive heterochromatin of the most diverse evolutionarily distant organisms. TEs enrichment in constitutive heterochromatin was originally described in the model organism Drosophila ...
René Massimiliano Marsano +1 more
doaj +1 more source
The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast. [PDF]
PLoS Genetics, 2014 Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation.
Scott P Kallgren +8 more
doaj +1 more source
Different behaviour of C-banded peri-centromeric heterochromatin between sex chromosomes and autosomes in Polyphagan beetles [PDF]
Comparative Cytogenetics, 2019 Heterochromatin variation was studied after C-banding of male karyotypes with a XY sex formula from 224 species belonging to most of the main families of Coleoptera.
Anne-Marie Dutrillaux +1 more
doaj +3 more sources