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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin [PDF]
Nature, 2017 Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
A. Larson +8 more
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Heterochromatin: Guardian of the Genome [PDF]
Annual Review of Cell and Developmental Biology, 2018 Constitutive heterochromatin is a major component of the eukaryotic nucleus and is essential for the maintenance of genome stability. Highly concentrated at pericentromeric and telomeric domains, heterochromatin is riddled with repetitive sequences and has evolved specific ways to compartmentalize, silence, and repair repeats.
Janssen, Aniek +2 more
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Establishment and evolution of heterochromatin [PDF]
Annals of the New York Academy of Sciences, 2020 AbstractThe eukaryotic genome is packaged into transcriptionally active euchromatin and silent heterochromatin, with most studies focused on the former encompassing the majority of protein‐coding genes. The recent development of various sequencing techniques has refined this classic dichromatic partition and has better illuminated the composition ...
Jing Liu +5 more
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Nature Communications, 2021 The heterochromatin compartment is key for genome stability and cell fate transitions. Here, by tracking the heterochromatin response to UV damage in real time, the authors reveal how heterochromatin features are preserved following a genotoxic stress ...
Anna Fortuny +6 more
doaj +2 more sources
The Cell Biology of Heterochromatin
Cells, 2022 A conserved feature of virtually all higher eukaryotes is that the centromeres are embedded in heterochromatin. Here we provide evidence that this tight association between pericentric heterochromatin and the centromere is essential for proper metaphase ...
Brandt Warecki, William Sullivan
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Heterochromatin in plant meiosis
NucleusHeterochromatin is an organizational property of eukaryotic chromosomes, characterized by extensive DNA and histone modifications, that is associated with the silencing of transposable elements and repetitive sequences.
Cong Wang +3 more
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Heterochromatin as an Important Driver of Genome Organization
Frontiers in Cell and Developmental Biology, 2020 Heterochromatin is a constituent of eukaryotic genomes with functions spanning from gene expression silencing to constraining DNA replication and repair.
Andrés Penagos-Puig +1 more
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Heterochromatin and nucleic acid
Agricultural and Food Science, 1948 Heterokromaattisiksi tämän käsitteen laajimmassa merkityksessä on nimitetty kromosominosia, jotka spiraloitumiseensa ja värjäytyväisyyteensä nähden jossain tuman vaiheessa eroavat muista, eukromaattisista kromosominosista. Heterokromatiini, sen rakenne ja toiminta, ovat erikoisesti viimeisen kymmenen vuoden aikana olleet vilkkaan tutkimuksen kohteena ...
Eeva Therman-Suomalainen
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Nature reviews. Molecular cell biology, 2022 Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes, where it ensures their transcriptional silencing.
Jan Padeken +2 more
semanticscholar +1 more source
Epigenetics & Chromatin, 2022 Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an ortholog of mammalian HP1, lead to heterochromatin formation. However, S.
Junsoo Oh +3 more
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