Results 1 to 10 of about 73,923 (265)

Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance

Nature Communications, 2021
The heterochromatin compartment is key for genome stability and cell fate transitions. Here, by tracking the heterochromatin response to UV damage in real time, the authors reveal how heterochromatin features are preserved following a genotoxic stress ...
Anna Fortuny, Audrey Chansard, Pierre Caron, Odile Chevallier, Olivier Leroy, Olivier Renaud, Sophie E. Polo   +6 more
doaj   +2 more sources

Heterochromatin as an Important Driver of Genome Organization

Frontiers in Cell and Developmental Biology, 2020
Heterochromatin is a constituent of eukaryotic genomes with functions spanning from gene expression silencing to constraining DNA replication and repair.
Andrés Penagos-Puig, Mayra Furlan-Magaril   +1 more
doaj   +2 more sources

Fission yeast Caprin protein is required for efficient heterochromatin establishment. [PDF]

PLoS Genet
Heterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving ...
Zhang H, Kapitonova E, Orrego A, Spanos C, Strachan J, Bayne EH.   +5 more
europepmc   +2 more sources

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair. [PDF]

Nat Commun
The CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown.
Li F, Zhang T, Syed A, Elbakry A, Holmer N, Nguyen H, Mukkavalli S, Greenberg RA, D'Andrea AD.   +8 more
europepmc   +2 more sources

Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction [PDF]

Nucleus
Aberrant nuclear morphology is a hallmark of human disease and causes nuclear dysfunction. Perturbed nuclear mechanics via reduced heterochromatin weakens the nucleus resulting in nuclear blebbing and rupture.
Manning G, Li A, Eskndir N, Currey M, Stephens A.   +4 more
europepmc   +2 more sources

Correlative light and soft X-ray tomography of in situ mesoscale heterochromatin structure in intact cells. [PDF]

Sci Rep
Heterochromatin organization is critical to many genome-related programs including transcriptional silencing and DNA repair. While super-resolution imaging, electron microscopy, and multiomics methods have provided indirect insights into the ...
Gupta R, Goswami Y, Yuan L, Roy B, Pereiro E, Shivashankar GV.   +5 more
europepmc   +2 more sources

Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance

Nature reviews. Molecular cell biology, 2022
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes, where it ensures their transcriptional silencing.
Jan Padeken, Stephen P. Methot, S. Gasser   +2 more
semanticscholar   +1 more source

The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin

Epigenetics & Chromatin, 2022
Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an ortholog of mammalian HP1, lead to heterochromatin formation. However, S.
Junsoo Oh, Soojin Yeom, Jiyeon Park, Jung-Shin Lee   +3 more
doaj   +1 more source

53BP1 regulates heterochromatin through liquid phase separation

Nature Communications, 2022
Human 53BP1 is primarily known as a key player in regulating DNA double strand break (DSB) repair choice; however, its involvement in other biological process is less well understood.
Lei Zhang, X. Geng, Fangfang Wang, Jinshan Tang, Y. Ichida, Arishya Sharma, Sora Jin, Mingyue Chen, Mingliang Tang, Franklin Mayca Pozo, Wenxiu Wang, Janet Wang, Michal Wozniak, Xiaoxia Guo, M. Miyagi, Fulai Jin, Yongjie Xu, Xinsheng Yao, Youwei Zhang   +18 more
semanticscholar   +1 more source

Global regulation of heterochromatin spreading by Leo1 [PDF]

Open Biology, 2015
Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries ...
Laure Verrier, Francesca Taglini, Ramon R. Barrales, Shaun Webb, Takeshi Urano, Sigurd Braun, Elizabeth H. Bayne   +6 more
doaj   +1 more source