Results 91 to 100 of about 117,333 (292)

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

CAF-1 is essential for heterochromatin organization in pluripotent embryonic cells. [PDF]

PLoS Genetics, 2006
During mammalian development, chromatin dynamics and epigenetic marking are important for genome reprogramming. Recent data suggest an important role for the chromatin assembly machinery in this process. To analyze the role of chromatin assembly factor 1
Martin Houlard, Soizik Berlivet, Aline V Probst, Jean-Pierre Quivy, Patrick Héry, Geneviève Almouzni, Matthieu Gérard   +6 more
doaj   +1 more source

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Advanced Science, EarlyView.
Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang   +3 more
wiley   +1 more source

High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model

Epigenetics & Chromatin, 2009
Background Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that show variegation of the eye color ...
Vogel Maartje J, Pagie Ludo, Talhout Wendy, Nieuwland Marja, Kerkhoven Ron M, van Steensel Bas   +5 more
doaj   +1 more source

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [PDF]

, 2010
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes.
Alekseyenko, Artyom A, Bishop, Eric P, Canfield, Theresa K, Elgin, Sarah CR, Ernst, Jason, Gorchakov, Andrey A, Gu, Tingting, Jung, Youngsook L, Karpen, Gary H, Kellis, Manolis, Kharchenko, Peter V, Kuroda, Mitzi I, Larschan, Erica, Linder-Basso, Daniela, Luquette, Lovelace J, MacAlpine, David M, Minoda, Aki, Park, Peter J, Park, Richard W, Pirrotta, Vincenzo, Plachetka, Annette, Riddle, Nicole C, Sabo, Peter J, Sandstrom, Richard, Schwartz, Yuri B, Shanower, Gregory, Stamatoyannopoulos, John A, Thurman, Robert E, Tolstorukov, Michael Y, Xi, Ruibin   +29 more
core   +4 more sources

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Chromatin phase separation and nuclear shape fluctuations are correlated in a polymer model of the nucleus

Nucleus
Abnormal cell nuclear shapes are hallmarks of diseases, including progeria, muscular dystrophy, and many cancers. Experiments have shown that disruption of heterochromatin and increases in euchromatin lead to nuclear deformations, such as blebs and ...
Ali Goktug Attar, Jaroslaw Paturej, Edward J. Banigan, Aykut Erbaş   +3 more
doaj   +1 more source

Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization [PDF]

, 1990
A new strategy for analyzing chromosomal evolution in primates is presented using chromosomal in situ suppression (CISS) hybridization. Biotin-labeled DNA libraries from flow-sorted human chromosomes are hybridized to chromosome preparations of ...
Anna Jauch, Bickmore, Cremer, Cremer, de Grouchy, Dutrillaux, Holmquist, Johannes Wienberg, Lalley, Lichter, Lichter, Lichter, O'Brien, Ohno, Pinkel, Roscoe Stanyon, Seuánez, Stanyon, Thomas Cremer, Van Dilla, Weber, Wienberg, Yunis   +22 more
core   +1 more source

Respiratory Involvement in HIST1H1E‐Related Rahman Syndrome: A Case of Severe Mixed Apnea

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Rahman syndrome (HIST1H1E‐related neurodevelopmental syndrome, OMIM #617537) is a rare autosomal‐dominant condition caused by truncating variants in the C‐terminal domain of the HIST1H1E gene. It is characterized by macrocephaly, hypotonia, craniofacial anomalies, and multisystem anomalies.
Nada Barakat, Marjolaine Champagne, Mathieu Bergeron, Philippe Dodin, Nadia Roumeliotis   +4 more
wiley   +1 more source