Results 91 to 100 of about 85,707 (260)

Karyotypes and heterochromatin variation (C-bands) in Melipona species (Hymenoptera, Apidae, Meliponinae)

Genetics and Molecular Biology, 1998
We describe the karyotypes of eight bee species of the genus Melipona and compare them in terms of heterochromatin content and location (C-banding technique).
Marla Piumbini Rocha, Silvia das Graças Pompolo   +1 more
doaj   +1 more source

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

Nature Communications, 2019
DiGeorge syndrome critical region 8 (DGCR8) is a critical component of the canonical microprocessor complex for microRNA biogenesis. However, the non-canonical functions of DGCR8 have not been studied.
Li-Jun Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillén, J. I. Izpisúa Belmonte, P. Chan, J. Qu, Guang-Hui Liu   +14 more
semanticscholar   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair

Nucleus, 2019
Constitutive heterochromatin is considered as a functionally inert genome compartment, important for its architecture and stability. How such stable structure is maintained is not well understood.
Vadim O. Chagin, Britta Reinhart, Annette Becker, Oliver Mortusewicz, K. Laurence Jost, Alexander Rapp, Heinrich Leonhardt, M. Cristina Cardoso   +7 more
doaj   +1 more source

Chromatin loops associated with active genes and heterochromatin shape rice genome architecture for transcriptional regulation

Nature Communications, 2019
Insight into high-resolution three-dimensional genome organization and its effect on transcription remains largely elusive in plants. Here, using a long-read ChIA-PET approach, we map H3K4me3- and RNA polymerase II (RNAPII)-associated promoter–promoter ...
Lun Zhao, Shuangqi Wang, Zhilin Cao, Weizhi Ouyang, Qing Zhang, Liang Xie, Ruiqin Zheng, Minrong Guo, Meng Ma, Zhe Hu, W. Sung, Qifa Zhang, Guoliang Li, Xingwang Li   +13 more
semanticscholar   +1 more source

A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Small Methods, EarlyView.
This study describes the development and applications of a transgenic lamin‐based senescence reporter platform based on changes in lamin‐B1‐ and lamin‐A intensities during senescence‐induction. The reporter platform is a versatile tool, allowing to screen for and sort senescent cancer cells, allowing marker integration (for example incorporating IL6 ...
Jacinta van de Grint, Mengqi Huang, Ruben Sangers, Hanny Odijk, Thom Reuvers, Jose M. Heredia‐Genestar, Anja Raams, Tsung Wai Kan, Joris Pothof, Roland Kanaar, Maayke M.P. Kuijten   +10 more
wiley   +1 more source

miR‐140‐5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson‐Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway

Aging Cell, EarlyView.
This study identifies a novel molecular mechanism involving miR‐140‐5p that contributes to the pathogenesis of HGPS. By decreasing NRF2 expression, miR‐140‐5p overexpression results in downregulation of the NRF2/KEAP1/HO‐1 antioxidant pathway in HGPS fibroblasts, leading to increased oxidative stress and mitochondrial dysfunction, two hallmarks of ...
Léa Toury, Diane Frankel, Sara Nael, Mario Abaji, Léa Le Goff, Marie Basset, Coraline Airault, Bertrand Vernay, Elva María Novoa‐del‐Toro, Catherine Bartoli, Anaïs Baudot, Frederique Magdinier, Elise Kaspi, Patrice Roll   +13 more
wiley   +1 more source

Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging

Aging Cell, EarlyView.
A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi, Na Yang, Evelyn Pizano, Lin Wang, James R. Occean, Chang‐Yi Cui, Ling Liu, Christopher Dunn, Frimpong Boadu, Qiong Meng, Nirad Banskota, Jen‐Hao Yang, Jinshui Fan, Supriyo De, Jianlin Cheng, Thomas A. Rando, Vittorio Sartorelli, Payel Sen   +17 more
wiley   +1 more source

Dynamics and Memory of Heterochromatin in Living Cells [PDF]

, 2012
Nathaniel A. Hathaway, Oliver Bell, H. Courtney Hodges, Erik L. Miller, Dana S. Neel, Robert H. Crabtree   +5 more
openalex   +1 more source

The cell proliferation antigen Ki-67 organises heterochromatin

eLife, 2016
Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation.
M. Sobecki, K. Mrouj, A. Camasses, N. Parisis, Emilien Nicolas, D. Llères, François Gerbe, S. Prieto, L. Krasinska, Alexandre David, M. Eguren, M. Birling, S. Urbach, S. Hem, J. Déjardin, Marcos Malumbres, P. Jay, V. Dulić, D. Lafontaine, R. Feil, D. Fisher   +20 more
semanticscholar   +1 more source