Results 131 to 140 of about 133,661 (356)

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, EarlyView.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

The Emerging Roles of Heterochromatin in Cell Migration

Frontiers in Cell and Developmental Biology, 2020
Cell migration is a key process in health and disease. In the last decade an increasing attention is given to chromatin organization in migrating cells. In various types of cells induction of migration leads to a global increase in heterochromatin levels.
Gabi Gerlitz
doaj   +1 more source

Heterochromatin structure and function [PDF]

Biology of the Cell, 2004
Abstract Although heterochromatin has long been used as a model for studying chromatin condensation and heritable gene silencing, it is only relatively recently that detailed information has become available on the mechanisms that underlie its structure. Current evidence suggests that these operate on at least three different levels.
openaire   +3 more sources

Epigenetic gene silencing by heterochromatin primes fungal resistance

Nature, 2019
Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent1–3. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitted through cell division provided the ...
Sito Torres-Garcia, Imtiyaz Yaseen, Manu Shukla, Pauline Audergon, S. White, A. Pidoux, R. Allshire   +6 more
semanticscholar   +1 more source

Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization [PDF]

, 1990
A new strategy for analyzing chromosomal evolution in primates is presented using chromosomal in situ suppression (CISS) hybridization. Biotin-labeled DNA libraries from flow-sorted human chromosomes are hybridized to chromosome preparations of ...
Anna Jauch, Bickmore, Cremer, Cremer, de Grouchy, Dutrillaux, Holmquist, Johannes Wienberg, Lalley, Lichter, Lichter, Lichter, O'Brien, Ohno, Pinkel, Roscoe Stanyon, Seuánez, Stanyon, Thomas Cremer, Van Dilla, Weber, Wienberg, Yunis   +22 more
core   +1 more source

Quantitative Analysis of DNA Double‐Strand Breaks in Genomic DNA Using Standard Curve Method

Journal of Clinical Laboratory Analysis, EarlyView.
This study presents a simple and cost‐effective method for quantifying DNA double‐strand breaks (DSBs) using standard curves based on Ct values from LM‐qPCR and the theoretical number of DSBs from enzyme‐digested DNA standards. Its simplicity, affordability, and high‐throughput capability make it a valuable tool for genotoxicity testing, environmental ...
Lihuang Guo, Hanying Dai, Jiancheng Li, Chenwei Li, Yue Huang, Keqian Xu   +5 more
wiley   +1 more source

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation

Nature Structural & Molecular Biology, 2019
The PIWI-interacting RNA (piRNA) pathway protects genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA-guided targeting of nuclear PIWI proteins to nascent transposon transcripts, yet the ...
Júlia Batki, J. Schnabl, Juncheng Wang, D. Handler, Veselin I. Andreev, Christian E. Stieger, M. Novatchkova, Lisa Lampersberger, Kotryna Kauneckaitė, W. Xie, K. Mechtler, D. Patel, J. Brennecke   +12 more
semanticscholar   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

A heterochromatin-dependent transcription machinery drives piRNA expression

Nature, 2017
Nuclear small RNA pathways safeguard genome integrity by establishing transcription-repressing heterochromatin at transposable elements. This inevitably also targets the transposon-rich source loci of the small RNAs themselves.
P. R. Andersen, Laszlo Tirian, Milica Vunjak, J. Brennecke   +3 more
semanticscholar   +1 more source