Results 161 to 170 of about 133,661 (356)
The FEBS Journal, EarlyView.Recent studies emphasize alternative functions of FTH1 relevant for nuclear processes, such as transcriptional regulation. This study shows a novel FTH1/BRD2 association in non‐small cell lung carcinoma (NSCLC). This nuclear interaction affects BRD2 protein stability in aggressive NSCLC cells.
Stefania Scicchitano +9 more
wiley +1 more source
CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair
Nature CommunicationsThe CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown.
Feng Li +8 more
doaj +1 more source
Nucleation and spreading of a heterochromatic domain in fission yeast
Nature Communications, 2016 Chromosomes contain large heterochromatin domains. Here, the authors measure the kinetics of heterochromatin formation in fission yeast and show both global and local feedbacks by nucleosome-bound enzymes are important for formation and stability of the ...
Michaela J. Obersriebnig +4 more
doaj +1 more source
Ageing versus developmental silencing: Answers from the epigenome. [PDF]
FEBS JIt is easier for young animals to regenerate damaged or missing tissues. In this Viewpoint, we propose that this is, in part, attributed to epigenetic changes, with chromatin becoming more closed and inaccessible as animals age. The timing of when this occurs differs depending on the tissue—some during the late developmental stages and others at the ...
Sadler KC, Storer MA, Bayin NS.
europepmc +2 more sources
HETEROCHROMATIN AND GENETIC ACTIVITY IN MEALY BUGS I. COMPENSATION FOR INACTIVE CHROMATIN BY INCREASE IN CELL NUMBER [PDF]
, 1968 Laurence Berlowitz +2 more
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Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression
The FEBS Journal, EarlyView.Genes repressed by the Polycomb system display greater chromatin folding compared to ‘regular’ inactive genes. The associated chromatin compaction, driven by PRC1‐H3K27me3 interactions, is modest and dynamic. This questions traditional models where Polycomb proteins repress transcription by sheltering genes from transcriptional activators.
Ludvig Lizana, Yuri B. Schwartz
wiley +1 more source
Constitutive heterochromatin and karyotype variation in Indian pygmy mouse, Mus dunni [PDF]
, 1975 T. Sharma, Gaurav Garg
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TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, EarlyView.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
iScienceSummary: Histone H3K9 methylated heterochromatin silences repetitive non-coding sequences and lineage-specific genes during development, but how tissue-specific genes escape from heterochromatin in differentiated cells is unclear.
Mi-Jin An +15 more
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