Results 161 to 170 of about 73,923 (265)

The role of inner nuclear membrane protein emerin in myogenesis

open access: yesThe FASEB Journal, Volume 39, Issue 7, 15 April 2025.
Emerin function is critical for proper genome reorganization and temporal gene expression necessary for terminal myogenic differentiation. Emerin interacts with both HDAC3 and histone methyltransferases (HMTs) to organize chromatin at the inner nuclear membrane.
Nicholas Marano, James M. Holaska
wiley   +1 more source

Transcriptional Profiling of Tofacitinib Treatment in Juvenile Idiopathic Arthritis: Implications for Treatment Response Prediction

open access: yesArthritis Care &Research, Volume 77, Issue 4, Page 513-521, April 2025.
Objective To assess changes in gene expression following tofacitinib treatment and investigate transcription patterns as potential predictors of treatment response in patients with active juvenile idiopathic arthritis (JIA). Methods Whole‐blood samples were collected from patients with JIA at baseline and after 18 weeks of open‐label tofacitinib ...
Esraa Eloseily   +7 more
wiley   +1 more source

Ten principles of heterochromatin formation and function

open access: yesNature reviews. Molecular cell biology, 2017
R. Allshire, H. Madhani
semanticscholar   +1 more source

3D Mechanical Confinement Directs Muscle Stem Cell Fate and Function

open access: yesAdvanced Biology, Volume 9, Issue 4, April 2025.
This study reveals that the physical environment surrounding muscle stem cells (MuSCs) plays a crucial role in their function. Using a 3D hydrogel system, it shows that increased confinement preserves MuSC stemness by limiting activation, proliferation, and differentiation.
GaYoung Park   +3 more
wiley   +1 more source

Hybrid EMT Phenotype and Cell Membrane Tension Promote Colorectal Cancer Resistance to Ferroptosis

open access: yesAdvanced Science, Volume 12, Issue 15, April 17, 2025.
Colorectal cancer cells (CRCs) cultured in 3D soft fibrin exhibit hybrid epithelial–mesenchymal transition (EMT) mediated ferroptosis resistance via WNT/β‐catenin signaling. Unlike 2D cells, 3D CRCs exhibit reduced E‐cadherin, knockout of which further enhances the defense against ferroptosis via adhesion‐mediated tension.
Xiaowei Wei   +12 more
wiley   +1 more source

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