Results 161 to 170 of about 124,493 (360)
Andrology, EarlyView.Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
HETEROCHROMATIN AND GENETIC ACTIVITY IN MEALY BUGS I. COMPENSATION FOR INACTIVE CHROMATIN BY INCREASE IN CELL NUMBER [PDF]
, 1968 Laurence Berlowitz +2 more
openalex +1 more source
Nucleation and spreading of a heterochromatic domain in fission yeast
Nature Communications, 2016 Chromosomes contain large heterochromatin domains. Here, the authors measure the kinetics of heterochromatin formation in fission yeast and show both global and local feedbacks by nucleosome-bound enzymes are important for formation and stability of the ...
Michaela J. Obersriebnig +4 more
doaj +1 more source
Nuclear destabilisation – a possible genesis of cancer?
Biological Reviews, EarlyView.ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott +4 more
wiley +1 more source
Constitutive heterochromatin and karyotype variation in Indian pygmy mouse, Mus dunni [PDF]
, 1975 T. Sharma, Gaurav Garg
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The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis
Cancer Science, EarlyView.In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley +1 more source
Unsupervised Classification for Tiling Arrays: ChIP-chip and Transcriptome
, 2011 Tiling arrays make possible a large scale exploration of the genome thanks to probes which cover the whole genome with very high density until 2 000 000 probes.
Aubourg, Sébastien +4 more
core +3 more sources
THE CONSTRUCTION OF RING CHROMOSOMES OF AUTOSOMAL HETEROCHROMATIN IN DROSOPHILA MELANOGASTER [PDF]
, 1978 Arthur J. Hilliker
openalex +1 more source