Results 21 to 30 of about 124,493 (360)

PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina

Nucleus, 2023
The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva, Yu-Chia Cheng, Cheryl L. Smith, Richard A. Katz, Andrey Poleshko   +4 more
doaj   +1 more source

H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation. [PDF]

Epigenetics Chromatin
Background Heterochromatin is a fundamental component of eukaryotic chromosome architecture, crucial for genome stability and cell type-specific gene regulation.
Fukuda K, Shimura C, Shinkai Y.
europepmc   +2 more sources

Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex

Epigenetics & Chromatin, 2021
Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood.
Martina Weigt, Qingsong Gao, Hyoju Ban, Haijin He, Guido Mastrobuoni, Stefan Kempa, Wei Chen, Fei Li   +7 more
doaj   +1 more source

Pre-implantation mouse embryos cultured In vitro under different oxygen concentrations show altered ultrastructures [PDF]

, 2020
Assisted Reproductive Technologies routinely utilize different culture media and oxygen (O2) concentrations to culture human embryos. Overall, embryos cultured under physiological O2 tension (5%) have improved development compared to embryos cultured ...
Antonouli, S, Belli, M, Macchiarelli, G, Nottola, Sa, Palmerini, Mg, Rinaudo, P, Ruggeri, E   +6 more
core   +1 more source

Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Nature Communications, 2021
Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms.
Thomas Montavon, N. Shukeir, Galina A. Erikson, Bettina Engist, Megumi Onishi-Seebacher, Devon Ryan, Y. Musa, Gerhard Mittler, A. G. Meyer, C. Genoud, T. Jenuwein   +10 more
semanticscholar   +1 more source

Heterochromatin Focuses on Senescence [PDF]

Molecular Cell, 2005
A key step in cellular senescence is the packaging of proliferation-promoting genes into repressive chromatin or heterochromatin. Recent work has described a novel histone component and mode of assembly of this senescence-associated heterochromatin.
Jessica K. Tyler, Laura L. Schulz
openaire   +3 more sources

Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]

, 2016
Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
A Ellahi, A Pidoux, A Selmecki, aF Straight, BD Strahl, C Ketel, C Li, C Trapnell, Ca Froyd, CJ Merrick, D Kadosh, DE Gottschling, GD Shankaranarayana, H Chibana, H Chibana, J Haran, J Huang, J Huang, J Nakayama, J Pérez-Martín, J Wendland, JC Tanny, JS Smith, Ka Morano, KR Hansen, L Vasiljeva, LH Freitas-Junior, LN Rusche, M Bryk, M Bühler, M Dubarry, M Paschini, M Van het Hoog, MA Pfaller, MD De Backer, MJ McEachern, N Saksouk, PA Dumesic, PR Lephart, PR Lephart, R Kaur, RB Wilson, RJ Bennett, S Greiss, S Henikoff, S Imai, S Kueng, S Rea, SI Iwaguchi, T Jones, T Kobayashi, T Kobayashi, T Kouzarides, VM Bruno, W Shou, WS Chu, X Bi   +56 more
core   +1 more source

Rapid epigenetic adaptation to uncontrolled heterochromatin spreading

eLife, 2015
Heterochromatin, a highly compact chromatin state characterized by histone H3K9 methylation and HP1 protein binding, silences the underlying DNA and influences the expression of neighboring genes.
Jiyong Wang, Bharat D Reddy, Songtao Jia
doaj   +1 more source

Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs

Stem Cell Research & Therapy, 2020
Background Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been characterized as two characteristics
Hailong Liu, Biao Huang, Shaolong Xue, Kin Pong U, Lai Ling Tsang, Xiaohu Zhang, Gang Li, Xiaohua Jiang   +7 more
doaj   +1 more source

TALEN outperforms Cas9 in editing heterochromatin target sites

Nature Communications, 2021
Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments.
Surbhi Jain, Saurabh Shukla, Che Yang, Meng Zhang, Z. Fatma, Manasi Lingamaneni, Shireen Abesteh, S. Lane, Xiong Xiong, Yuchuan Wang, Charles M. Schroeder, P. Selvin, Huimin Zhao   +12 more
semanticscholar   +1 more source