Results 21 to 30 of about 85,707 (260)

De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses

Viruses, 2021
The Human Herpesviruses persist in the form of a latent infection in specialized cell types. During latency, the herpesvirus genomes associate with cellular histone proteins and the viral lytic genes assemble into transcriptionally repressive ...
Sara A. Dochnal, Alison K. Francois, Anna R. Cliffe   +2 more
doaj   +1 more source

Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. [PDF]

PLoS Genetics, 2012
Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging. However, the role of heterochromatin in animal aging has been controversial.
Kimberly Larson, Shian-Jang Yan, Amy Tsurumi, Jacqueline Liu, Jun Zhou, Kriti Gaur, Dongdong Guo, Thomas H Eickbush, Willis X Li   +8 more
doaj   +1 more source

Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Nature Communications, 2021
Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms.
Thomas Montavon, N. Shukeir, Galina A. Erikson, Bettina Engist, Megumi Onishi-Seebacher, Devon Ryan, Y. Musa, Gerhard Mittler, A. G. Meyer, C. Genoud, T. Jenuwein   +10 more
semanticscholar   +1 more source

Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms.

PLoS Genetics, 2023
Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability.
Sarah MacKinnon, Viviane Pagé, Jennifer J Chen, Ali Shariat-Panahi, Ryan D Martin, Terence E Hébert, Jason C Tanny   +6 more
doaj   +1 more source

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Nature, 2017
Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
A. Larson, D. Elnatan, Madeline M. Keenen, Michael J. Trnka, Jonathan B. Johnston, A. Burlingame, D. Agard, S. Redding, G. Narlikar   +8 more
semanticscholar   +1 more source

Molecular Complexes at Euchromatin, Heterochromatin and Centromeric Chromatin

International Journal of Molecular Sciences, 2021
Chromatin consists of a complex of DNA and histone proteins as its core components and plays an important role in both packaging DNA and regulating DNA metabolic pathways such as DNA replication, transcription, recombination, and chromosome segregation ...
Olivia Morrison, J. Thakur
semanticscholar   +1 more source

Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena

Cell Reports, 2017
RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood.
Jan H. Suhren, Tomoko Noto, Kensuke Kataoka, Shan Gao, Yifan Liu, Kazufumi Mochizuki   +5 more
doaj   +1 more source

Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors. [PDF]

PLoS ONE, 2015
The eukaryotic genome is assembled into distinct types of chromatin. Gene-rich euchromatin has active chromatin marks, while heterochromatin is gene-poor and enriched for silencing marks.
Manasi S Apte, Victoria H Meller
doaj   +1 more source

Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation

Cell Reports, 2020
Summary: Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance.
Si Young Lee, Stevephen Hung, Caroline Esnault, Rakesh Pathak, Kory R. Johnson, Oluwadamilola Bankole, Akira Yamashita, Hongen Zhang, Henry L. Levin   +8 more
doaj   +1 more source

TALEN outperforms Cas9 in editing heterochromatin target sites

Nature Communications, 2021
Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments.
Surbhi Jain, Saurabh Shukla, Che Yang, Meng Zhang, Z. Fatma, Manasi Lingamaneni, Shireen Abesteh, S. Lane, Xiong Xiong, Yuchuan Wang, Charles M. Schroeder, P. Selvin, Huimin Zhao   +12 more
semanticscholar   +1 more source