Results 21 to 30 of about 73,923 (265)
From Effective Interactions Extracted Using Hi-C Data to Chromosome Structures in Conventional and Inverted Nuclei [PDF]
PRX Life 1, 013010 (2023), 2023 Contact probabilities between loci, separated by arbitrary genomic distance, for a number of cell types have been reported using genome-wide chromosome conformation capture (Hi-C) experiments. How to extract the effective interaction energies between active euchromatin (A) and inactive heterochromatin (B) directly from the experimental data, without an
arxiv +1 more source
Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
Nature Communications, 2021 Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms.
Thomas Montavon +10 more
semanticscholar +1 more source
Rapid epigenetic adaptation to uncontrolled heterochromatin spreading
eLife, 2015 Heterochromatin, a highly compact chromatin state characterized by histone H3K9 methylation and HP1 protein binding, silences the underlying DNA and influences the expression of neighboring genes.
Jiyong Wang, Bharat D Reddy, Songtao Jia
doaj +1 more source
De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses
Viruses, 2021 The Human Herpesviruses persist in the form of a latent infection in specialized cell types. During latency, the herpesvirus genomes associate with cellular histone proteins and the viral lytic genes assemble into transcriptionally repressive ...
Sara A. Dochnal +2 more
doaj +1 more source
Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023 FA is a progressive neurodegenerative disorder, but the primary cause of death is heart disease which occurs in 60% of the patients. Several functions of frataxin have been proposed, but none of them fully explain why its deficiency causes the FA phenotypes nor why the most affected cell types are neurons and cardiomyocytes.
Mariana B. Angulo +6 more
wiley +1 more source
TALEN outperforms Cas9 in editing heterochromatin target sites
Nature Communications, 2021 Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments.
Surbhi Jain +12 more
semanticscholar +1 more source
Genome mapping and characterization of the
BMC Genomics, 2010 Background Heterochromatin plays an important role in chromosome function and gene regulation. Despite the availability of polytene chromosomes and genome sequence, the heterochromatin of the major malaria vector Anopheles gambiae has not been mapped and
Sharakhova Maria V +6 more
doaj +1 more source
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. [PDF]
PLoS Genetics, 2012 Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging. However, the role of heterochromatin in animal aging has been controversial.
Kimberly Larson +8 more
doaj +1 more source
PLoS Genetics, 2023 Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability.
Sarah MacKinnon +6 more
doaj +1 more source
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
Nature, 2017 Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
A. Larson +8 more
semanticscholar +1 more source