Results 21 to 30 of about 133,661 (356)
Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex
Epigenetics & Chromatin, 2021 Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood.
Martina Weigt +7 more
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PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
doaj +1 more source
Maternal depletion of Piwi, a component of the RNAi system, impacts heterochromatin formation in Drosophila. [PDF]
PLoS Genetics, 2013 A persistent question in epigenetics is how heterochromatin is targeted for assembly at specific domains, and how that chromatin state is faithfully transmitted.
Tingting Gu, Sarah C R Elgin
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Stem Cell Research & Therapy, 2020 Background Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been characterized as two characteristics
Hailong Liu +7 more
doaj +1 more source
Rapid epigenetic adaptation to uncontrolled heterochromatin spreading
eLife, 2015 Heterochromatin, a highly compact chromatin state characterized by histone H3K9 methylation and HP1 protein binding, silences the underlying DNA and influences the expression of neighboring genes.
Jiyong Wang, Bharat D Reddy, Songtao Jia
doaj +1 more source
Complete loss of H3K9 methylation dissolves mouse heterochromatin organization
Nature Communications, 2021 Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms.
Thomas Montavon +10 more
semanticscholar +1 more source
Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]
, 2016 Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
A Ellahi +56 more
core +1 more source
Heterochromatin Focuses on Senescence [PDF]
Molecular Cell, 2005 A key step in cellular senescence is the packaging of proliferation-promoting genes into repressive chromatin or heterochromatin. Recent work has described a novel histone component and mode of assembly of this senescence-associated heterochromatin.
Jessica K. Tyler, Laura L. Schulz
openaire +3 more sources
TALEN outperforms Cas9 in editing heterochromatin target sites
Nature Communications, 2021 Genome editing critically relies on selective recognition of target sites. However, despite recent progress, the underlying search mechanism of genome-editing proteins is not fully understood in the context of cellular chromatin environments.
Surbhi Jain +12 more
semanticscholar +1 more source
Genome mapping and characterization of the
BMC Genomics, 2010 Background Heterochromatin plays an important role in chromosome function and gene regulation. Despite the availability of polytene chromosomes and genome sequence, the heterochromatin of the major malaria vector Anopheles gambiae has not been mapped and
Sharakhova Maria V +6 more
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