Results 21 to 30 of about 67,655 (251)
De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses
Viruses, 2021 The Human Herpesviruses persist in the form of a latent infection in specialized cell types. During latency, the herpesvirus genomes associate with cellular histone proteins and the viral lytic genes assemble into transcriptionally repressive ...
Sara A. Dochnal +2 more
doaj +1 more source
Mediator directs co-transcriptional heterochromatin assembly by RNA interference-dependent and -independent pathways. [PDF]
PLoS Genetics, 2013 Heterochromatin at the pericentromeric repeats in fission yeast is assembled and spread by an RNAi-dependent mechanism, which is coupled with the transcription of non-coding RNA from the repeats by RNA polymerase II. In addition, Rrp6, a component of the
Eriko Oya +5 more
doaj +1 more source
PLoS Genetics, 2019 H3K9 methylation (H3K9me) is a conserved marker of heterochromatin, a transcriptionally silent chromatin structure. Knowledge of the mechanisms for regulating heterochromatin distribution is limited.
Masato Sorida +12 more
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Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors. [PDF]
PLoS ONE, 2015 The eukaryotic genome is assembled into distinct types of chromatin. Gene-rich euchromatin has active chromatin marks, while heterochromatin is gene-poor and enriched for silencing marks.
Manasi S Apte, Victoria H Meller
doaj +1 more source
A Temperature Increase Induces Atf1/Pcr1-Dependent Rapid Depletion of Histones in Transcriptionally Activated Gene Bodies in Fission Yeast. [PDF]
Genes CellsIn the fission yeast Schizosaccharomyces pombe, the transcription factor complex Atf1‐Pcr1 is activated by phosphorylation upon heat stress to initiate a rapid cellular response. This activated complex facilitates the significant eviction of histone H3 from the transcribed regions of specific genes termed HOT‐DOGs. RNAP II, depicted as delivery trucks,
Hoshino A +4 more
europepmc +2 more sources
Nature Communications, 2021 The heterochromatin compartment is key for genome stability and cell fate transitions. Here, by tracking the heterochromatin response to UV damage in real time, the authors reveal how heterochromatin features are preserved following a genotoxic stress ...
Anna Fortuny +6 more
doaj +1 more source
A simulation model of heterochromatin formation at submolecular detail
iScience, 2022 Summary: Heterochromatin is a physical state of the chromatin fiber that maintains gene repression during cell development. Although evidence exists on molecular mechanisms involved in heterochromatin formation, a detailed structural mechanism of ...
Michael R. Williams +3 more
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Early-replicating heterochromatin [PDF]
Genes & Development, 2003 Euchromatin, which has an open structure and is frequently transcribed, tends to replicate in early S phase. Heterochromatin, which is more condensed and rarely transcribed, usually replicates in late S phase. Here, we report significant deviation from this correlation in the fission yeast,Schizosaccharomyces pombe.
Soo-Mi, Kim +2 more
openaire +2 more sources
The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic
eLife, 2016 Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions.
Joel M Swenson +4 more
doaj +1 more source
Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2011 Recent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics, however, remain obscure.
Bo O Zhou +6 more
doaj +1 more source