Results 31 to 40 of about 104,859 (295)

Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms.

open access: yesPLoS Genetics, 2023
Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability.
Sarah MacKinnon   +6 more
doaj   +1 more source

FISH mapping and molecular organization of the major repetitive sequences of tomato [PDF]

open access: yes, 2008
This paper presents a bird's-eye view of the major repeats and chromatin types of tomato. Using fluorescence in-situ hybridization (FISH) with Cot-1, Cot-10 and Cot-100 DNA as probes we mapped repetitive sequences of different complexity on pachytene ...
Chang, S.B.   +10 more
core   +2 more sources

De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses

open access: yesViruses, 2021
The Human Herpesviruses persist in the form of a latent infection in specialized cell types. During latency, the herpesvirus genomes associate with cellular histone proteins and the viral lytic genes assemble into transcriptionally repressive ...
Sara A. Dochnal   +2 more
doaj   +1 more source

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. [PDF]

open access: yes, 2017
Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
Agard, David A   +8 more
core   +1 more source

Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]

open access: yes, 2020
Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David   +7 more
core   +2 more sources

Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena

open access: yesCell Reports, 2017
RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood.
Jan H. Suhren   +5 more
doaj   +1 more source

Chromatin insulator elements: establishing barriers to set heterochromatin boundaries [PDF]

open access: yes, 2012
Epigenomic profiling has revealed that substantial portions of genomes in higher eukaryotes are organized into extensive domains of transcriptionally repressive chromatin.
Adam G West   +9 more
core   +1 more source

Mediator directs co-transcriptional heterochromatin assembly by RNA interference-dependent and -independent pathways. [PDF]

open access: yesPLoS Genetics, 2013
Heterochromatin at the pericentromeric repeats in fission yeast is assembled and spread by an RNAi-dependent mechanism, which is coupled with the transcription of non-coding RNA from the repeats by RNA polymerase II. In addition, Rrp6, a component of the
Eriko Oya   +5 more
doaj   +1 more source

Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.

open access: yesPLoS Genetics, 2019
H3K9 methylation (H3K9me) is a conserved marker of heterochromatin, a transcriptionally silent chromatin structure. Knowledge of the mechanisms for regulating heterochromatin distribution is limited.
Masato Sorida   +12 more
doaj   +1 more source

Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors. [PDF]

open access: yesPLoS ONE, 2015
The eukaryotic genome is assembled into distinct types of chromatin. Gene-rich euchromatin has active chromatin marks, while heterochromatin is gene-poor and enriched for silencing marks.
Manasi S Apte, Victoria H Meller
doaj   +1 more source

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