Results 31 to 40 of about 85,707 (260)

A simulation model of heterochromatin formation at submolecular detail

iScience, 2022
Summary: Heterochromatin is a physical state of the chromatin fiber that maintains gene repression during cell development. Although evidence exists on molecular mechanisms involved in heterochromatin formation, a detailed structural mechanism of ...
Michael R. Williams, Yan Xiaokang, Nathaniel A. Hathaway, Dmitri Kireev   +3 more
doaj   +1 more source

The loss of heterochromatin is associated with multiscale three-dimensional genome reorganization and aberrant transcription during cellular senescence

Genome Research, 2021
Heterochromatin remodeling is critical for various cell processes. In particular, the “loss of heterochromatin” phenotype in cellular senescence is associated with the process of aging and age-related disorders. Although biological processes of senescent
Xianglin Zhang, Xuehui Liu, Zhenhai Du, Lei Wei, Huan Fang, Qiongye Dong, Jing Niu, Yanda Li, Juntao Gao, Michael Q. Zhang, Wei Xie, Xiaowo Wang   +11 more
semanticscholar   +1 more source

Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.

PLoS Genetics, 2019
H3K9 methylation (H3K9me) is a conserved marker of heterochromatin, a transcriptionally silent chromatin structure. Knowledge of the mechanisms for regulating heterochromatin distribution is limited.
Masato Sorida, Takahiro Hirauchi, Hiroaki Ishizaki, Wataru Kaito, Atsushi Shimada, Chie Mori, Yuji Chikashige, Yasushi Hiraoka, Yutaka Suzuki, Yasuyuki Ohkawa, Hiroaki Kato, Shinya Takahata, Yota Murakami   +12 more
doaj   +1 more source

Mediator directs co-transcriptional heterochromatin assembly by RNA interference-dependent and -independent pathways. [PDF]

PLoS Genetics, 2013
Heterochromatin at the pericentromeric repeats in fission yeast is assembled and spread by an RNAi-dependent mechanism, which is coupled with the transcription of non-coding RNA from the repeats by RNA polymerase II. In addition, Rrp6, a component of the
Eriko Oya, Hiroaki Kato, Yuji Chikashige, Chihiro Tsutsumi, Yasushi Hiraoka, Yota Murakami   +5 more
doaj   +1 more source

HP1 reshapes the nucleosome core to promote phase separation of heterochromatin

Nature, 2019
Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
S. Sanulli, Michael J. Trnka, V. Dharmarajan, Ryan W. Tibble, B. Pascal, A. Burlingame, P. Griffin, J. Gross, G. Narlikar   +8 more
semanticscholar   +1 more source

Spreading and epigenetic inheritance of heterochromatin require a critical density of histone H3 lysine 9 tri-methylation

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance In multicellular organisms, a single genome gives rise to a multitude of cell types by enforcing appropriate gene expression patterns. Epigenetic mechanisms involving modification of histones, including tri-methylation of histone H3 lysine 9
Amber R Cutter DiPiazza, Nitika Taneja, Jothy Dhakshnamoorthy, David Wheeler, Sahana Holla, S. Grewal   +5 more
semanticscholar   +1 more source

The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.

PLoS Genetics, 2022
The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient levels, but the mechanistic link is not well understood.
Kehan Bao, Chun-Min Shan, Xiao Chen, Gulzhan Raiymbek, Jeremy G Monroe, Yimeng Fang, Takenori Toda, Kristin S Koutmou, Kaushik Ragunathan, Chao Lu, Luke E Berchowitz, Songtao Jia   +11 more
doaj   +1 more source

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states

Cell Reports, 2021
Summary: Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle.
Magdalena Murawska, R.A. Greenstein, Tamas Schauer, Karl C.F. Olsen, Henry Ng, Andreas G. Ladurner, Bassem Al-Sady, Sigurd Braun   +7 more
doaj   +1 more source

How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance

Cells, 2020
Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure.
Raquel Sales-Gil, Paola Vagnarelli
doaj   +1 more source

Imaging the Response to DNA Damage in Heterochromatin Domains

Frontiers in Cell and Developmental Biology, 2022
The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance, compact chromatin states, broadly categorized as heterochromatin, present a challenging ...
Audrey Chansard, Enrico Pobega, Pierre Caron, Sophie E. Polo   +3 more
doaj   +1 more source