Results 51 to 60 of about 73,923 (265)

The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic

eLife, 2016
Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions.
Joel M Swenson, Serafin U Colmenares, Amy R Strom, Sylvain V Costes, Gary H Karpen   +4 more
doaj   +1 more source

Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2011
Recent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics, however, remain obscure.
Bo O Zhou, Shan-Shan Wang, Yang Zhang, Xiao-Hong Fu, Wei Dang, Brian A Lenzmeier, Jin-Qiu Zhou   +6 more
doaj   +1 more source

Imaging the Response to DNA Damage in Heterochromatin Domains

Frontiers in Cell and Developmental Biology, 2022
The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance, compact chromatin states, broadly categorized as heterochromatin, present a challenging ...
Audrey Chansard, Enrico Pobega, Pierre Caron, Sophie E. Polo   +3 more
doaj   +1 more source

Heterochromatin: Guardian of the Genome.

Annual Review of Cell and Developmental Biology, 2018
Constitutive heterochromatin is a major component of the eukaryotic nucleus and is essential for the maintenance of genome stability. Highly concentrated at pericentromeric and telomeric domains, heterochromatin is riddled with repetitive sequences and ...
A. Janssen, Serafin U. Colmenares, G. Karpen   +2 more
semanticscholar   +1 more source

Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

Nature Cell Biology, 2020
Following fertilization in mammals, the gametes are reprogrammed to create a totipotent zygote, a process that involves de novo establishment of chromatin domains.
Adam Burton, V. Brochard, Carmen Galán, E. Ruiz-Morales, Quirze Rovira, Diego Rodriguez-Terrones, Kai Kruse, Stéphanie Le Gras, Vishnu S. Udayakumar, H. Chin, André Eid, Xiaoyu Liu, Chenfei Wang, Shaorong Gao, S. Pradhan, Juan M. Vaquerizas, N. Beaujean, T. Jenuwein, M. Torres-Padilla   +18 more
semanticscholar   +1 more source

Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays [PDF]

, 2014
Heterochromatin protein 1 (HP1) participates in establishing and maintaining heterochromatin via its histone modification dependent chromatin interactions. In recent papers HP1 binding to nucleosomal arrays was measured in vitro and interpreted in terms of nearest-neighbor cooperative binding. This mode of chromatin interactions could lead to spreading
arxiv   +1 more source

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Science, 2019
How dipeptide repeats cause pathology A repeat expansion in the chromosome 9 open reading frame 72 (C9orf72) gene is the most common known cause of two neurodegenerative diseases: frontotemporal dementia and amyotrophic lateral sclerosis.
Yong-Jie Zhang, Lin Guo, Patrick K Gonzales, Tania F. Gendron, Yanwei Wu, Karen R. Jansen-West, Aliesha D O'Raw, Sarah R Pickles, M. Prudencio, Y. Carlomagno, Mariam A. Gachechiladze, Connor H. Ludwig, Ruilin Tian, Jeannie Chew, M. DeTure, Wen‐lang Lin, Jimei Tong, Lillian M. Daughrity, Mei Yue, Yuping Song, Jonathan W Andersen, M. Castanedes-Casey, Aishe Kurti, A. Datta, G. Antognetti, A. McCampbell, R. Rademakers, B. Oskarsson, D. Dickson, M. Kampmann, Michael E. Ward, J. Fryer, C. Link, J. Shorter, L. Petrucelli   +34 more
semanticscholar   +1 more source

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

Nucleic Acids Research, 2020
Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has long been known as a master transcriptional repressor of autophagy. Here, we identify a novel role for ZKSCAN3 in alleviating senescence that is independent of its autophagy-related activity.
Huifang Hu, Qianzhao Ji, Moshi Song, Jie Ren, Zunpeng Liu, Zehua Wang, Xiaoqian Liu, K. Yan, Jianli Hu, Yaobin Jing, Si Wang, Weiqi Zhang, Guang-Hui Liu, J. Qu   +13 more
semanticscholar   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Heterochromatin in plant meiosis

Nucleus
Heterochromatin is an organizational property of eukaryotic chromosomes, characterized by extensive DNA and histone modifications, that is associated with the silencing of transposable elements and repetitive sequences.
Cong Wang, Zhiyu Chen, Gregory P. Copenhaver, Yingxiang Wang   +3 more
doaj   +1 more source