Results 51 to 60 of about 133,661 (356)

ATM Breaks into Heterochromatin [PDF]

Molecular Cell, 2008
Heterochromatin is refractory to DNA transactions, including repair. In a recent issue of Molecular Cell, Goodarzi et al. (2008) reveal how the central transducing kinase of the DNA damage response relieves this natural barrier by increasing heterochromatic DNA accessibility.
Oscar Fernandez-Capetillo, André Nussenzweig   +1 more
openaire   +3 more sources

RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster. [PDF]

, 2019
Tandemly-repeated DNAs, or satellites, are enriched in heterochromatic regions of eukaryotic genomes and contribute to nuclear structure and function. Some satellites are transcribed, but we lack direct evidence that specific satellite RNAs are required ...
Allshire, Brown, Cai, Chen, Demarco, Dernburg, Ding, Eren-Ghiani, Ferree, Herbert, Hoskins, Hoskins, Jagannathan, Jain, Jandura, Jayaramaiah Raja, Johnson, Kaessmann, Kelemen, Kost, Larracuente, Legendre, Lohe, Lohe, McKee, McNulty, Ni, Nicholson, Pathak, Rathke, Rathke, Rinn, Rošić, Shirai, Shpiz, Steinhauer, Strom, Sun, Velazquez Camacho, Wei, White-Cooper, White-Cooper, Yap, Yuan, Zhu   +44 more
core   +2 more sources

Assessing the Epigenetic Status of Human Telomeres [PDF]

, 2019
The epigenetic modifications of human telomeres play a relevant role in telomere functions and cell proliferation. Therefore, their study is becoming an issue of major interest.
Vaquero Sedas, María Isabel, Vega Palas, Miguel Ángel   +1 more
core   +1 more source

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states

Cell Reports, 2021
Summary: Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle.
Magdalena Murawska, R.A. Greenstein, Tamas Schauer, Karl C.F. Olsen, Henry Ng, Andreas G. Ladurner, Bassem Al-Sady, Sigurd Braun   +7 more
doaj   +1 more source

SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae [PDF]

, 2011
Budding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans ...
Anna T. Vetter, Beth A. Sullivan, Delphine Theodorou, Edoardo Petrini, Felix Krueger, J. Ross Miller, Konrad Paszkiewicz, Margaret R. Crawford, Mickaël Durand-Dubief, Nicholas A. Kent, Patrick Varga-Weisz, Rachael R. Harris, Rosa Maria Correra, William Ryan Will   +13 more
core   +4 more sources

How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance

Cells, 2020
Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure.
Raquel Sales-Gil, Paola Vagnarelli
doaj   +1 more source

The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.

PLoS Genetics, 2022
The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient levels, but the mechanistic link is not well understood.
Kehan Bao, Chun-Min Shan, Xiao Chen, Gulzhan Raiymbek, Jeremy G Monroe, Yimeng Fang, Takenori Toda, Kristin S Koutmou, Kaushik Ragunathan, Chao Lu, Luke E Berchowitz, Songtao Jia   +11 more
doaj   +1 more source

Heterochromatin Dynamics

PLoS Biology, 2003
Heterochromatin is usually thought of as a stable and inactive region of the genome.
openaire   +5 more sources

Imaging the Response to DNA Damage in Heterochromatin Domains

Frontiers in Cell and Developmental Biology, 2022
The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance, compact chromatin states, broadly categorized as heterochromatin, present a challenging ...
Audrey Chansard, Enrico Pobega, Pierre Caron, Sophie E. Polo   +3 more
doaj   +1 more source

Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes

Nucleic Acids Research, 2019
The eukaryotic genome is functionally organized into domains of transcriptionally active euchromatin and domains of highly compact transcriptionally silent heterochromatin.
R. J. Roach, M. Garavís, C. González, G. Jameson, V. Filichev, T. Hale   +5 more
semanticscholar   +1 more source