Results 51 to 60 of about 124,493 (360)
ATM Breaks into Heterochromatin [PDF]
Molecular Cell, 2008 Heterochromatin is refractory to DNA transactions, including repair. In a recent issue of Molecular Cell, Goodarzi et al. (2008) reveal how the central transducing kinase of the DNA damage response relieves this natural barrier by increasing heterochromatic DNA accessibility.
Oscar Fernandez-Capetillo +1 more
openaire +3 more sources
Assessing the Epigenetic Status of Human Telomeres [PDF]
, 2019 The epigenetic modifications of human telomeres play a relevant role in telomere functions and cell proliferation. Therefore, their study is becoming an issue of major interest.
Vaquero Sedas, María Isabel +1 more
core +1 more source
DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]
, 2018 DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola +3 more
core +1 more source
High resolution physical mapping of single gene fragments on pachytene chromosome 4 and 7 of Rosa [PDF]
, 2015 Background: Rosaceae is a family containing many economically important fruit and ornamental species. Although fluorescence in situ hybridization (FISH)-based physical mapping of plant genomes is a valuable tool for map-based cloning, comparative ...
Khrustaleva, Ludmila I +2 more
core +2 more sources
Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
core +2 more sources
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Nucleic Acids Research, 2019 The eukaryotic genome is functionally organized into domains of transcriptionally active euchromatin and domains of highly compact transcriptionally silent heterochromatin.
R. J. Roach +5 more
semanticscholar +1 more source
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
Protein & Cell, 2020 SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses. It remains elusive how human somatic stem cell populations might be impacted by SIRT7. Here, we found that SIRT7 expression declines during
Shijia Bi +11 more
semanticscholar +1 more source
The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
PLoS Genetics, 2022 The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient levels, but the mechanistic link is not well understood.
Kehan Bao +11 more
doaj +1 more source
Microbiology Spectrum, 2023 The survival of malaria parasites in the changing human blood environment largely depends on their ability to alter gene expression by epigenetic mechanisms.
Lucas Michel-Todó +6 more
doaj +1 more source
Fission yeast Caprin protein is required for efficient heterochromatin establishment. [PDF]
PLoS GenetHeterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving ...
Zhang H +5 more
europepmc +2 more sources