Results 71 to 80 of about 102,928 (311)
Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation [PDF]
, 2019 DNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors.
Chereji, Razvan V. +4 more
core +1 more source
The SUV39 Family of H3K9 Methyltransferases in Skeletal Muscle Stem Cells. [PDF]
FASEB BioadvThe SUV39 family members are well known for methylating the Lysine 9 of the histone H3 (H3K9) in order to compact the chromatin and contributing to gene repression. We describe their active role in proliferating and differentiating muscle stem cells, how they prevent from inflammation and fibrosis during muscle regeneration and the future avenues ...
Garcia P, Ait-Si-Ali S, Le Grand F.
europepmc +2 more sources
Cell nucleus elastography with the adjoint-based inverse solver [PDF]
Computer Methods and Programs in Biomedicine, In press, 2023 Background and Objectives: The mechanics of the nucleus depends on cellular structures and architecture, and impact a number of diseases. Nuclear mechanics is yet rather complex due to heterogeneous distribution of dense heterochromatin and loose euchromatin domains, giving rise to spatially variable stiffness properties.
arxiv
Ribosomal DNA heterochromatin in plants [PDF]
Cytogenetic and Genome Research, 2005 The aim of this review is to integrate earlier results and recent findings to present the current state-of-the-art vision concerning the dynamic behavior of the ribosomal DNA (rDNA) fraction in plants. The global organization and behavioral features of rDNA make it a most useful system to analyse the relationship between chromatin topology and gene ...
Neves, N. +5 more
openaire +4 more sources
Advanced Biology, EarlyView.Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe +4 more
wiley +1 more source
FISH-aimed karyotype analysis in Aconitum subgen : aconitum reveals excessive rDNA sites in tetraploid taxa [PDF]
, 2018 The location of 5S and 35S rDNA sequences in chromosomes of four Aconitum subsp. Aconitum species was analyzed after fluorescence in situ hybridization (FISH). Both in diploids (2n = 2x = 16; Aconitum variegatum, A. degenii) and tetraploids (2n = 4× = 32;
Grabowska-Joachimiak, Aleksandra +4 more
core +2 more sources
Advanced Biology, EarlyView.The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez +8 more
wiley +1 more source
Cells, 2020 The stability of pericentromeric heterochromatin is maintained by repressive epigenetic control mechanisms, and failure to maintain this stability may cause severe diseases such as immune deficiency and cancer.
Simone Johansen +1 more
doaj +1 more source
Heterochromatin revisited [PDF]
Nature Reviews Genetics, 2007 The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome.
Grewal, Shiv I. S., Jia, Songtao
openaire +4 more sources
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source