Results 81 to 90 of about 102,928 (311)

Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation

Cell Reports, 2020
Summary: Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance.
Si Young Lee, Stevephen Hung, Caroline Esnault, Rakesh Pathak, Kory R. Johnson, Oluwadamilola Bankole, Akira Yamashita, Hongen Zhang, Henry L. Levin   +8 more
doaj  

Heterochromatin is late

The Journal of Cell Biology, 2005
In 1953—the year that Watson and Crick published those findings “of considerable biological interest”—Howard and Pelc (1953) showed that DNA synthesis occurred in a discrete phase of the cell cycle. They had labeled DNA with radioactive phosphate.
openaire   +3 more sources

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

Targeting and regulatory mechanisms in chromosome-wide gene regulation using Drosophila melanogaster as a model organism [PDF]

, 2010
Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2010O cromossoma 4 de Drosophila melanogaster é muito heterocromático, sendo rico em DNA satélite e DNA de elementos transposáveis. Apesar das suas
Figueiredo, Ana Margarida Adónis, 1986-
core  

LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer [PDF]

, 2015
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer. It is local-ized in different cellular compartments, but its nuclear function has not been investigated so
Aceto, Andrulis, Bartke, Beer, Bhattacharyya, Chubb, Finlan, Giamas, Grewal, Guelen, Heger, Hendrickx, Hung, Hurtado, Iyengar, Kathiriya, Kind, Kotera, Kumaran, Lee, Li, Li, Lin, Lo, Meuleman, Mohammed, Nielsen, Peng, Peric-Hupkes, Pickersgill, Poleshko, Pérez-Tenorio, Rajhans, Reddy, Roux, Roy, Ryan, Sadaie, Silva, Solovei, Stebbing, Stebbing, Towbin, van der Lee, Vizcaíno, Vogel, Wang, Weis, White, Xu, Yokoe, Zeng, Ziv   +52 more
core   +4 more sources

Early-replicating heterochromatin [PDF]

Genes & Development, 2003
Euchromatin, which has an open structure and is frequently transcribed, tends to replicate in early S phase. Heterochromatin, which is more condensed and rarely transcribed, usually replicates in late S phase. Here, we report significant deviation from this correlation in the fission yeast,Schizosaccharomyces pombe.
Soo-Mi Kim, Dharani D. Dubey, Joel A. Huberman   +2 more
openaire   +3 more sources

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Advanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim   +9 more
wiley   +1 more source

RNAi and Heterochromatin Assembly [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
The involvement of RNA interference (RNAi) in heterochromatin formation has become clear largely through studies in the fission yeast Schizosaccharomyces pombe and plants like Arabidopsis thaliana. This article discusses how heterochromatic small interfering RNAs are produced and how the RNAi machinery participates in the formation and function of ...
Danesh Moazed, Robert A. Martienssen
openaire   +2 more sources

Selfish centromeres, selfless heterochromatin

Cell, 2021
Centromeres are specialized regions on chromosomes recruiting a set of proteins required for faithful chromosome segregation. Differences in centromere strength can potentially bias chromosome segregation toward one of the daughter cells during division. Kumon et al. propose a new model of evolutionary impact on the balance of centromere strength.
Nikalayevich, Elvira, Verlhac, Marie-Hélène   +1 more
openaire   +3 more sources

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, EarlyView.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source