Results 81 to 90 of about 85,707 (260)
The Emerging Roles of Heterochromatin in Cell Migration
Frontiers in Cell and Developmental Biology, 2020 Cell migration is a key process in health and disease. In the last decade an increasing attention is given to chromatin organization in migrating cells. In various types of cells induction of migration leads to a global increase in heterochromatin levels.
Gabi Gerlitz
doaj +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source
DAXX safeguards heterochromatin formation in embryonic stem cells [PDF]
, 2023 Antoine Canat +11 more
openalex +1 more source
bioRxiv, 2019 Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the
A. Poleshko +8 more
semanticscholar +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Epigenetics & Chromatin, 2009 Background Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that show variegation of the eye color ...
Vogel Maartje J +5 more
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The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
Nature Structural & Molecular Biology, 2019 The PIWI-interacting RNA (piRNA) pathway protects genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA-guided targeting of nuclear PIWI proteins to nascent transposon transcripts, yet the ...
Júlia Batki +12 more
semanticscholar +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Epigenetic gene silencing by heterochromatin primes fungal resistance
Nature, 2019 Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent1–3. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitted through cell division provided the ...
Sito Torres-Garcia +6 more
semanticscholar +1 more source
Quantitative Analysis of DNA Double‐Strand Breaks in Genomic DNA Using Standard Curve Method
Journal of Clinical Laboratory Analysis, EarlyView.This study presents a simple and cost‐effective method for quantifying DNA double‐strand breaks (DSBs) using standard curves based on Ct values from LM‐qPCR and the theoretical number of DSBs from enzyme‐digested DNA standards. Its simplicity, affordability, and high‐throughput capability make it a valuable tool for genotoxicity testing, environmental ...
Lihuang Guo +5 more
wiley +1 more source