Results 1 to 10 of about 9,440 (222)

Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle [PDF]

Frontiers in Immunology, 2022
The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA stabilization and translational regulation. According to their different cellular
Jingming Wang, Jingming Wang, Jingming Wang, Di Sun, Di Sun, Di Sun, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Yukun Zhu, Yukun Zhu, Yukun Zhu, Sai Mao, Sai Mao, Sai Mao, Xuming Ou, Xuming Ou, Xuming Ou, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Juan Huang, Juan Huang, Juan Huang, Qun Gao, Qun Gao, Qun Gao, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Dekang Zhu, Dekang Zhu, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu   +49 more
doaj   +4 more sources

Autoantibodies to heterogeneous nuclear ribonucleoproteins [PDF]

Autoimmunity, 2005
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are among the most abundant proteins in the eukaryotic cell nucleus and play a direct role in several aspects of the RNA life including splicing, export of the mature RNAs and translation. To date, approximately 30 proteins have been identified.
Roberto Caporali, Serena Bugatti, Eleonora Bruschi   +2 more
exaly   +6 more sources

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS [PDF]

Acta Neuropathologica Communications, 2019
Frontotemporal lobar degeneration (FTLD) is pathologically subdivided based on the presence of particular pathological proteins that are identified in inclusion bodies observed post-mortem. The FTLD-FUS subgroup is defined by the presence of the fused in
Lauren M. Gittings, Sandrine C. Foti, Bridget C. Benson, Priya Gami-Patel, Adrian M. Isaacs, Tammaryn Lashley   +5 more
doaj   +5 more sources

Role of Heterogeneous Nuclear Ribonucleoproteins in the Cancer-Immune Landscape. [PDF]

Int J Mol Sci, 2023
Cancer remains the second leading cause of death, accounting for approximately 20% of all fatalities. Evolving cancer cells and a dysregulated immune system create complex tumor environments that fuel tumor growth, metastasis, and resistance. Over the past decades, significant progress in deciphering cancer cell behavior and recognizing the immune ...
Sudhakaran M, Doseff AI.
europepmc   +5 more sources

Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B. [PDF]

Cell Mol Life Sci, 2009
The hnRNP A/B proteins are among the most abundant RNA-binding proteins, forming the core of the ribonucleoprotein complex that associates with nascent transcripts in eukaryotic cells. There are several paralogs in this subfamily, each of which is subject to alternative transcript splicing and post-translational modifications.
He Y, Smith R.
europepmc   +9 more sources

Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases. [PDF]

Mol Neurobiol, 2021
AbstractHeterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse family of RNA binding proteins with multifarious roles. They are involved, directly or indirectly, in alternative splicing, transcriptional and translational regulation, stress granule formation, cell cycle regulation, and axonal transport.
Low YH, Asi Y, Foti SC, Lashley T.
europepmc   +5 more sources

SUMO modification of heterogeneous nuclear ribonucleoproteins. [PDF]

Mol Cell Biol, 2004
Small ubiquitin-related modifiers (SUMOs) are proteins that are posttranslationally conjugated to other cellular proteins, particularly those that localize and function in the nucleus. Enzymes regulating SUMO modification localize in part to nuclear pore complexes (NPCs), indicating that modification of some proteins may occur as they are translocated ...
Vassileva MT, Matunis MJ.
europepmc   +4 more sources

EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells. [PDF]

PLoS ONE, 2015
KRAS mutational status is considered a negative predictive marker of the response to anti-EGFR therapies in colorectal cancer (CRC) patients. However, conflicting data exist regarding the variable response to EGFR-targeted therapy.
Desamparados Roda, Josefa Castillo, Marcelino Telechea-Fernández, Anabel Gil, Gerardo López-Rodas, Luís Franco, Patricia González-Rodríguez, Susana Roselló, J Alejandro Pérez-Fidalgo, Elena R García-Trevijano, Andrés Cervantes, Rosa Zaragozá   +11 more
doaj   +2 more sources

From development to disease: the neuronal role of hnRNPs through the lens of Drosophila [PDF]

Frontiers in Cell and Developmental Biology
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of RNA-binding proteins (RBPs) involved in multiple aspects of nucleic acid metabolism, ranging from DNA maintenance to RNA splicing and translation.
Chiara Stefanelli, Davide Colaianni, Cristiano De Pittà, Gabriella M. Mazzotta   +3 more
doaj   +2 more sources

A guide to selecting high-performing antibodies for Heterogeneous nuclear ribonucleoproteins A2/B1(hnRNP A2/B1) (UniProt ID: P22626) for use in western blot, immunoprecipitation, and immunofluorescence [version 1; peer review: 2 approved] [PDF]

F1000Research
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) is a key RNA-binding protein involved in alternative splicing, mRNA transport, and local translation processes essential for neuronal development and synaptic plasticity.
Maryam Fothouhi, Carl Laflamme, Donovan Worrall, Riham Ayoubi, Vera Ruíz Moleón, Charles Alende, Joel Ryan, Sara González Bolívar, Thomas M Durcan, Vincent Francis, Claire M Brown, Peter S McPherson   +11 more
doaj   +2 more sources