Results 11 to 20 of about 9,440 (222)

Involvement of Heterogeneous Nuclear Ribonucleoproteins in Viral Multiplication [PDF]

Future Virology, 2012
The study of virus–host interactions is a major goal in molecular virology and provides new effective targets for antiviral therapies. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a group of cellular RNA-binding proteins localized predominantly within the nucleus, which participate in gene transcription and subsequent RNA post ...
Viviana Castilla
exaly   +5 more sources

Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation [PDF]

Journal of Cell Science, 2005
Overexpression of heterogeneous nuclear ribonucleoproteins (hnRNPs) A2 and B1 has been observed in a variety of tumour types, however, it is unknown whether this dysregulation is a consequence of, or a driving force for, unregulated cell proliferation.
Yaowu He, Matthew A Brown, Joseph A Rothnagel   +2 more
exaly   +9 more sources

Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells [PDF]

International Journal of Molecular Sciences, 2019
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres.
Shishkin SS, Kovalev LI, Pashintseva NV, Kovaleva MA, Lisitskaya K.   +4 more
exaly   +4 more sources

Diverse roles of heterogeneous nuclear ribonucleoproteins in viral life cycle [PDF]

Frontiers in Virology, 2022
Understanding the host-virus interactions helps to decipher the viral replication strategies and pathogenesis. Viruses have limited genetic content and rely significantly on their host cell to establish a successful infection.
Krishna Bhattarai, Martin Holcik
doaj   +3 more sources

Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice [PDF]

Nature Communications, 2020
Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the biogenesis, localization and transport of RNA. Here authors investigate a role for hnRNPs in sterol metabolism in mice and provide insights into their role in selective promoter
Zhengyi Zhang, An-Chieh Feng, David Salisbury, Xin Liu, Xiaohui Wu, Jason Kim, Irina Lapina, Dan Wang, Brennan Lee, Josue Fraga, Calvin Pan, Kevin J. Williams, Aldons J. Lusis, Phil Scumpia, Tamer Sallam   +14 more
doaj   +2 more sources

hnRNP A2B1 as a promising therapeutic target for radiomodulatory drug development: evidence from computational and experimental studies [PDF]

Frontiers in Pharmacology
Radiation modulation is critical due to the growing risks of radiation exposure in medical, occupational, and environmental settings. This study explored the potential of heterogeneous nuclear ribonucleoproteins (hnRNPs), particularly hnRNP A2B1, as ...
N. S. Lubinets, N. S. Lubinets, I. S. Tonkii, V. A. Sazonova, K. Dutta, A. E. Putintseva, O. O. Volkova, E. V. Skorb, P. Zun, A. Ruzov, A. Ruzov, V. Yu. Kravtsov, V. Yu. Kravtsov, S. Shityakov   +13 more
doaj   +2 more sources

Cellular hnRNP AB inhibits avian influenza virus RNA synthesis via blocking UAP56-mediated nuclear export of PB2 mRNA [PDF]

Veterinary Research
Avian influenza viral ribonucleoproteins (vRNPs) complete genome transcription and replication by interacting with host proteins, and RNA-dependent RNA polymerase (RdRp) is its major component.
Shuhui Liu, Yue Sun, Yunling Peng, Chenchen Xu, Suquan Song, Liping Yan   +5 more
doaj   +2 more sources

Phase separation as an emerging regulatory framework in antibody class switching and genome stability [PDF]

Frontiers in Immunology
The spatial and temporal organization of nuclear processes is increasingly interpreted through principles associated with liquid–liquid phase separation (LLPS), whereby multivalent interactions among proteins and nucleic acids generate dynamic ...
Ahmed M. Refaat, Ahmed M. Refaat, Hidetaka Shimizu, Takaaki Yasuhara   +3 more
doaj   +2 more sources

Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres. [PDF]

Cancers (Basel), 2019
The A/B subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs A/B), which includes hnRNP A1, A2/B1, and A3, plays an important role in cell proliferation.
Wang TH, Chen CC, Hsiao YC, Lin YH, Pi WC, Huang PR, Wang TV, Chen CY.   +7 more
europepmc   +2 more sources

The role of interactions of long non-coding RNAs and heterogeneous nuclear ribonucleoproteins in regulating cellular functions. [PDF]

Biochem J, 2017
Long non-coding RNAs (lncRNAs) are emerging as critical regulators of various biological processes and human diseases. The mechanisms of action involve their interactions with proteins, RNA and genomic DNA.
Sun X, Haider Ali MSS, Moran M.
europepmc   +3 more sources