Translational Oncology, 2022 Bladder cancer is prevalent cancer worldwide with poor outcomes for patients with high-grade disease. Emerging evidence shows that alteration of metabolic status drives tumorigenesis in bladder cancer. As long noncoding RNA urothelial cancer associated 1
Chi-Wei Chen
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HNRNPK (heterogeneous nuclear ribonucleoprotein K) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HNRNPK (heterogeneous nuclear ribonucleoprotein K), with data on DNA, on the protein encoded, and where the gene is implicated.
Mikula, M, Ostrowski, J
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An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes [PDF]
, 2009 Nuclear mRNA export is a crucial step in eukaryotic gene expression, which is in yeast coupled to cotranscriptional messenger ribonucleoprotein particle ( mRNP) assembly and surveillance.
Attila Rácz +17 more
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Functional interaction of Sam68 and heterogeneous nuclear ribonucleoprotein K [PDF]
Oncogene, 2002 Sam68 is a target of the c-Src tyrosine kinase. We previously showed that overexpression of Sam68 functionally substitutes for, as well as synergies with, HIV-1 Rev in Rev-response element (RRE)-mediated gene expression and virus replication. Here we describe the identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a protein that ...
Jian-Ping, Yang +4 more
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Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection [PDF]
Journal of Virology, 2015 ABSTRACT Picornavirus infection involves a dynamic interplay of host and viral protein interactions that modulates cellular processes to facilitate virus infection and evade host antiviral defenses. Here, using a proteomics-based approach known as TAILS to identify protease-generated neo-N-terminal peptides, we identify a novel ...
Julienne M, Jagdeo +6 more
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Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy [PDF]
, 2012 This work was funded by the Wellcome Trust (grant ID WT078810MA)It is becoming increasingly clear that defects in RNA metabolism can lead to disease. Spinal muscular atrophy (SMA), a leading genetic cause of infant mortality, results from insufficient ...
Clelland, Allyson Kara +2 more
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Heterogeneous nuclear ribonucleoproteins C1/C2 identified as autoantigens by biochemical and mass spectrometric methods [PDF]
, 2000 Udgivelsesdato: 2000-nullThe antigenic specificity of an unusual antinuclear antibody pattern in three patient sera was identified after separating HeLa-cell nuclear extracts by two-dimensional (2D) gel electrophoresis and localizing the antigens by ...
Muncrief, T +4 more
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m6A-binding proteins: the emerging crucial performers in epigenetics
Journal of Hematology & Oncology, 2020 N6-methyladenosine (m6A) is a well-known post-transcriptional modification that is the most common type of methylation in eukaryotic mRNAs. The regulation of m6A is dynamic and reversible, which is erected by m6A methyltransferases (“writers”) and ...
Yanchun Zhao +3 more
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Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy
Cancer Biology & Therapy, 2023 Translocation of 14-3-3 protein epsilon (14-3-3ε) was found to be involved in Triptolide (Tp)-induced inhibition of colorectal cancer (CRC) cell proliferation.
Manlan Guo +12 more
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Heterogeneous Nuclear Ribonucleoprotein K Is a DNA-binding Transactivator [PDF]
Journal of Biological Chemistry, 1995 We have previously reported that heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the pyrimidine-rich strand of the CT element found in the human c-myc gene and activates CT reporter-driven gene expression in vivo. We now characterize the DNA and protein requirements for the interaction of hnRNP K with the CT element.
T, Tomonaga, D, Levens
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