The Potential Role of Cyclopeptides from Pseudostellaria heterophylla, Linum usitatissimum and Drymaria diandra, and Peptides Derived from Heterophyllin B as Dipeptidyl Peptidase IV Inhibitors for the Treatment of Type 2 Diabetes: An In Silico Study [PDF]
Metabolites, 2022 Dipeptidyl peptidase 4 (DPP4) inhibitors can treat type 2 diabetes by slowing GLP-1 degradation to increase insulin secretion. Studies have reported that Pseudostellaria heterophylla, Linum usita-tissimum (flaxseed), and Drymaria diandra, plants rich in ...
Hui-Jun Liao, Jason T. C. Tzen
doaj +7 more sources
The Biosynthesis of Heterophyllin B in Pseudostellaria heterophylla From prePhHB-Encoded Precursor [PDF]
Frontiers in Plant Science, 2019 Plant cyclic peptides (CPs) are a large group of small molecule metabolites found in a wide variety of plants, including traditional Chinese medicinal plants.
Wei Zheng +12 more
doaj +6 more sources
Heterophyllin B Ameliorates Lipopolysaccharide-Induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages by Suppressing the PI3K/Akt Pathways [PDF]
Molecules, 2018 Heterophyllin B (HB), an active cyclic peptide, is a compound existing in the ethyl acetate extract of Pseudostellaria heterophylla (Miq.) Pax and exhibited the activity of inhibiting the production of NO and cytokines, such as IL-1β and IL-6, in LPS ...
Chunjing Yang +7 more
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Exploring the Potential Pharmacologic Mechanism of Heterophyllin B in the Treatment of Esophageal Cancer by Network Pharmacology [PDF]
E3S Web of Conferences, 2021 This study used the method of network pharmacology to preliminarily predict the mechanism of Heterophyllin B(HB) inhibiting Esophageal Cancer(EC). We found the HB targets in the TCMSP and PuChem databases, and searched all EC-related targets in the ...
Chen Ting +6 more
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Investigating Potential GLP-1 Receptor Agonists in Cyclopeptides from Pseudostellaria heterophylla, Linum usitatissimum, and Drymaria diandra, and Peptides Derived from Heterophyllin B for the Treatment of Type 2 Diabetes: An In Silico Study [PDF]
Metabolites, 2022 GLP-1 receptor agonists stimulate GLP-1R to promote insulin secretion, whereas DPP4 inhibitors slow GLP-1 degradation. Both approaches are incretin-based therapies for T2D.
Hui-Jun Liao, Jason T. C. Tzen
doaj +4 more sources
Simulation of Pseudostellaria heterophylla distribution in China: assessing habitat suitability and bioactive component abundance under future climate change scenariosplant components [PDF]
Frontiers in Plant ScienceBackgroundPseudostellaria heterophylla is used in traditional Chinese medicine, so ensuring an adequate supply of plant material with high levels of bioactive components is important.MethodsUsing an optimized maximum entropy niche model and assays of ...
Xu Li +8 more
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Heterophyllin: A New Adenia Toxic Lectin with Peculiar Biological Properties. [PDF]
Toxins (Basel), 2023 Ribosome-inactivating proteins (RIPs) are plant toxins that were identified for their ability to irreversibly damage ribosomes, thereby causing arrest of protein synthesis and induction of cell death.
Bortolotti M +4 more
europepmc +3 more sources
Identification of heterophyllin B accumulation associated genes via WGCNA in Pseudostellaria heterophylla [PDF]
Frontiers in Plant SciencePseudostellaria heterophylla (Miq.) Pax (P. heterophylla) is a perennial medicinal herb in which heterophyllin B (HB) serves as one of the primary bioactive compounds.
Li-Yi Xu +10 more
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Heterophyllin B enhances transcription factor EB-mediated autophagy and alleviates pyroptosis and oxidative stress after spinal cord injury. [PDF]
Int J Biol SciTraumatic spinal cord injury (SCI) has devastating physical, psychosocial, and vocational implications for patients and caregivers. Heterophyllin B (HB) is a brain-permeable cyclopeptide from Pseudostellaria heterophylla that promotes axonal regeneration and neuroinflammation.
Zhang H +9 more
europepmc +3 more sources
Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K/AKT/β-catenin signaling. [PDF]
Mol Med Rep, 2016 The present study aimed to measure the effect of heterophyllin B (HB) on the adhesion and invasion of ECA-109 human esophageal carcinoma cells, and examine the possible mechanism involved. A Cell Counting kit 8 assay was performed to determine the cell viability.
Tantai JC, Zhang Y, Zhao H.
europepmc +4 more sources