Development of an antibody fragment that stabilizes GPCR/G-protein complexes [PDF]
Nature Communications, 2018 The determination of high resolution structures of G protein coupled receptors (GPCRs) in complex with heterotrimeric G proteins is challenging. Here authors develop an antibody fragment, mAB16, which stabilizes GPCR/G-protein complexes and facilitates ...
Shoji Maeda +9 more
doaj +3 more sources
Heterotrimeric G-Protein Signalers and RGSs in Aspergillus fumigatus [PDF]
Pathogens, 2020 The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various
Hee-Soo Park +3 more
doaj +2 more sources
Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets. [PDF]
Physiol Rep, 2018 Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Cao H +12 more
europepmc +3 more sources
Trade-Off Regulation in Plant Growth and Stress Responses Through the Role of Heterotrimeric G Protein Signaling [PDF]
PlantsUnlike animals, plants are sessile organisms that cannot migrate to more favorable conditions and must constantly adapt to a variety of biotic and abiotic stresses.
Horim Lee
doaj +2 more sources
Heterotrimeric G Proteins [PDF]
Cell, 2004 Bernhard Hampoelz, Juergen A. Knoblich
openalex +2 more sources
The heterotrimeric G protein β subunit RGB1 is required for seedling formation in rice. [PDF]
Rice (N Y), 2019 Gao Y +8 more
europepmc +3 more sources
Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa [PDF]
BMC Evolutionary Biology, 2018 Background Heterotrimeric G proteins are fundamental signaling proteins composed of three subunits, Gα and a Gβγ dimer. The role of Gα as a molecular switch is critical for transmitting and amplifying intracellular signaling cascades initiated by an ...
A. D. Lokits +4 more
doaj +2 more sources
Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G13. [PDF]
PLoS One, 2018 Guo X +4 more
europepmc +3 more sources
Current applications of mini G proteins to study the structure and function of G protein-coupled receptors [PDF]
AIMS Bioengineering, 2018 G protein-coupled receptors (GPCRs) regulate intracellular signalling pathways that contribute to virtually all aspects of cell function. Characterising GPCRs in each of their conformational states is key to understanding their mechanism of action, but ...
Byron Carpenter
doaj +3 more sources
Heterotrimeric G Protein Subunit Gene [PDF]
, 2020 National Cancer Institute
openalex +2 more sources