Results 41 to 50 of about 60,478 (190)

Correction to the pathogenic alternative splicing, caused by the common GNB3 c.825C>T allele, using a novel, antisense morpholino [PDF]

, 2016
The very common GNB3 c.825C>T polymorphism (rs5443), is present in approximately half of all human chromosomes. Significantly the presence of the GNB3 825T allele has been strongly associated, with predisposition to essential hypertension ...
Lester, Douglas H., McGlinchey, Jonathan C. P., Tummala, Hemanth   +2 more
core   +3 more sources

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

eLife, 2019
One of the largest membrane protein families in eukaryotes are G protein-coupled receptors (GPCRs). GPCRs modulate cell physiology by activating diverse intracellular transducers, prominently heterotrimeric G proteins. The recent surge in structural data
Ching-Ju Tsai, Jacopo Marino, Ricardo Adaixo, Filip Pamula, Jonas Muehle, Shoji Maeda, Tilman Flock, Nicholas MI Taylor, Inayatulla Mohammed, Hugues Matile, Roger JP Dawson, Xavier Deupi, Henning Stahlberg, Gebhard Schertler   +13 more
doaj   +1 more source

Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]

, 1999
RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S., Caron, Joan M., Chen, Ching-Kang, Druey, Kirk M., Jones, Teresa L. Z., Ugur, Ozlem   +5 more
core   +1 more source

Functional Interplay Between Arabidopsis NADPH Oxidases and Heterotrimeric G Protein

Molecular Plant-Microbe Interactions, 2013
The plant NADPH oxidases produce reactive oxygen species (ROS) in response to pathogens that have diverse functions in different cellular contexts. Distinct phenotypic outcomes may derive from the interaction of NADPH oxidase-dependent ROS with other ...
Miguel Angel Torres, Jorge Morales, Clara Sánchez-Rodríguez, Antonio Molina, Jeffery L. Dangl   +4 more
doaj   +1 more source

The repertoire of heterotrimeric G proteins and RGS proteins in Ciona intestinalis. [PDF]

PLoS ONE, 2009
BACKGROUND:Heterotrimeric G proteins and regulators of G protein signaling (RGS) proteins are key downstream interacting partners in the G protein coupled receptor (GPCR) signaling pathway.
R Prasobh, Narayanan Manoj
doaj   +1 more source

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs [PDF]

, 2016
Background G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways.
Aguinaga Andrés, David, Brugarolas Campillos, Marc, Canela Campos, Enric I., Casadó, Vicent, Cordomí, Arnau, Cortés Tejedor, Antonio, Franco Fernández, Rafael, García-Saez, Ana J., Lluís i Biset, Carme, Mallol Montero, Josefa, McCormick, Peter J., Moreno Guillén, Estefanía, Navarro Brugal, Gemma, Pardo, Leonardo, Pérez-Benito, Laura, Zelman-Femiak, Monika   +15 more
core   +3 more sources

Arabidopsis G‐protein interactome reveals connections to cell wall carbohydrates and morphogenesis

Molecular Systems Biology, 2011
The heterotrimeric G‐protein complex is minimally composed of Gα, Gβ, and Gγ subunits. In the classic scenario, the G‐protein complex is the nexus in signaling from the plasma membrane, where the heterotrimeric G‐protein associates with heptahelical G ...
Karsten Klopffleisch, Nguyen Phan, Kelsey Augustin, Robert S Bayne, Katherine S Booker, Jose R Botella, Nicholas C Carpita, Tyrell Carr, Jin‐Gui Chen, Thomas Ryan Cooke, Arwen Frick‐Cheng, Erin J Friedman, Brandon Fulk, Michael G Hahn, Kun Jiang, Lucia Jorda, Lydia Kruppe, Chenggang Liu, Justine Lorek, Maureen C McCann, Antonio Molina, Etsuko N Moriyama, M Shahid Mukhtar, Yashwanti Mudgil, Sivakumar Pattathil, John Schwarz, Steven Seta, Matthew Tan, Ulrike Temp, Yuri Trusov, Daisuke Urano, Bastian Welter, Jing Yang, Ralph Panstruga, Joachim F Uhrig, Alan M Jones   +35 more
doaj   +1 more source

A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase [PDF]

, 2018
Plant pattern recognition receptors (PRRs) perceive microbial and endogenous molecular patterns to activate immune signaling. The cytoplasmic kinase BIK1 acts downstream of multiple PRRs as a rate-limiting component, whose phosphorylation and ...
Chen, She, Feng, Feng, Gao, Chulei, Grubb, Lauren, Li, Lei, Li, Lin, Li, Meng, Liang, Xiangxiu, Ma, Miaomiao, Monaghan, Jacqueline, Wang, Jiayu, Wang, Jinlong, Xie, Qi, Yu, Feifei, Zhang, Xiaojuan, Zhou, Jian-Min, Zipfel, Cyril   +16 more
core   +2 more sources

Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis

Nature Communications, 2018
Gip1 sequesters heterotrimeric G proteins in the cytosolic pool which regulates G protein-coupled receptor signalling for eukaryotic chemotaxis. Here the authors provide the crystal structure of Gip1's G protein-binding region and show that mutations in ...
Takero Miyagawa, Hiroyasu Koteishi, Yoichiro Kamimura, Yukihiro Miyanaga, Kohei Takeshita, Atsushi Nakagawa, Masahiro Ueda   +6 more
doaj   +1 more source

A FRET-based biosensor for measuring Gα13 activation in single cells. [PDF]

PLoS ONE, 2018
Förster Resonance Energy Transfer (FRET) provides a way to directly observe the activation of heterotrimeric G-proteins by G-protein coupled receptors (GPCRs).
Marieke Mastop, Nathalie R Reinhard, Cristiane R Zuconelli, Fenna Terwey, Theodorus W J Gadella, Jakobus van Unen, Merel J W Adjobo-Hermans, Joachim Goedhart   +7 more
doaj   +1 more source