Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. [PDF]
, 2006 The archaeal/eukaryotic proliferating cell nuclear antigen (PCNA) toroidal clamp interacts with a host of DNA modifying enzymes, providing a stable anchorage and enhancing their respective processivities.
Andrew S. Doré +48 more
core +4 more sources
Gαi protein subunit: A step toward understanding its non-canonical mechanisms
Frontiers in Cell and Developmental Biology, 2022 The heterotrimeric G protein family plays essential roles during a varied array of cellular events; thus, its deregulation can seriously alter signaling events and the overall state of the cell. Heterotrimeric G-proteins have three subunits (α, β, γ) and
Soraya Villaseca +6 more
doaj +1 more source
Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish [PDF]
, 2016 Photoreceptors are highly specialized sensory neurons that possess a modified primary cilium called the outer segment. Photoreceptor outer segment formation and maintenance require highly active protein transport via a process known as intraflagellar ...
Akhtar +44 more
core +2 more sources
GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins. [PDF]
PLoS Computational Biology, 2012 After extra-cellular stimulation of G-Protein Coupled Receptors (GPCRs), GDP/GTP exchange appears as the key, rate limiting step of the intracellular activation cycle of heterotrimeric G-proteins.
Maxime Louet +2 more
doaj +1 more source
Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae. [PDF]
, 2011 Caveolae are flask-shaped invaginations in the plasma membrane that serve to compartmentalize and organize signal transduction processes, including signals mediated by G protein-coupled receptors and heterotrimeric G proteins.
H.A. Katus +8 more
core +3 more sources
mBio, 2014 Pasteurella multocida toxin (PMT) induces atrophic rhinitis in animals, which is characterized by a degradation of nasal turbinate bones, indicating an effect of the toxin on bone cells such as osteoblasts and osteoclasts.
Julia Strack +5 more
doaj +1 more source
Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces [PDF]
, 2017 G protein-coupled receptors (GPCRs) regulate cellular signalling through heterotrimeric G proteins and arrestins in response to an array of extracellular stimuli.
Carpenter, Byron, Tate, Christopher G.
core +1 more source
Real-time visualization of heterotrimeric G protein Gq activation in living cells
BMC Biology, 2011 Background Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living ...
Manders Erik MM +6 more
doaj +1 more source
Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation [PDF]
, 2016 G protein-coupled receptors (GPCRs) modulate cytoplasmic signalling in response to extracellular stimuli, and are important therapeutic targets in a wide range of diseases.
Carpenter, Byron, Tate, Christopher G.
core +1 more source
The cationic region of Rhes mediates its interactions with specific Gβ subunits [PDF]
, 2009 Ras homologue enriched in striatum (Rhes) is a small monomeric G protein which functions in a variety of cellular processes, including attenuation of G protein-coupled receptor (GPCR)signalling.
Davey, John +3 more
core +2 more sources