Results 61 to 70 of about 61,296 (269)

Gαi protein subunit: A step toward understanding its non-canonical mechanisms

Frontiers in Cell and Developmental Biology, 2022
The heterotrimeric G protein family plays essential roles during a varied array of cellular events; thus, its deregulation can seriously alter signaling events and the overall state of the cell. Heterotrimeric G-proteins have three subunits (α, β, γ) and
Soraya Villaseca, Gabriel Romero, María J. Ruiz, Carlos Pérez, Juan I. Leal, Lina M. Tovar, Marcela Torrejón   +6 more
doaj   +1 more source

A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase [PDF]

, 2018
Plant pattern recognition receptors (PRRs) perceive microbial and endogenous molecular patterns to activate immune signaling. The cytoplasmic kinase BIK1 acts downstream of multiple PRRs as a rate-limiting component, whose phosphorylation and ...
Chen, She, Feng, Feng, Gao, Chulei, Grubb, Lauren, Li, Lei, Li, Lin, Li, Meng, Liang, Xiangxiu, Ma, Miaomiao, Monaghan, Jacqueline, Wang, Jiayu, Wang, Jinlong, Xie, Qi, Yu, Feifei, Zhang, Xiaojuan, Zhou, Jian-Min, Zipfel, Cyril   +16 more
core   +2 more sources

Metal‐Directed Self‐Assembly in a Beta‐Sheet Miniprotein Scaffold

European Journal of Inorganic Chemistry, EarlyView.
A rationally engineered miniprotein, V14C, which is based on the beta β‐sheet Foldon domain, self‐assembles via a metal‐binding site to form well‐defined oligomers in the presence of Zn2+, Hg2+, and Cd2+. This modular design expands the toolbox for creating custom metalloproteins, enabling studies of metal–protein interactions for biochemical functions
Chandan Muni Reddy, Marcos R. Conde González, Jürgen H. Gross, Franziska Thomas   +3 more
wiley   +1 more source

Noncanonical G-Protein-Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin

mBio, 2014
Pasteurella multocida toxin (PMT) induces atrophic rhinitis in animals, which is characterized by a degradation of nasal turbinate bones, indicating an effect of the toxin on bone cells such as osteoblasts and osteoclasts.
Julia Strack, Hannah Heni, Ralf Gilsbach, Lutz Hein, Klaus Aktories, Joachim H. C. Orth   +5 more
doaj   +1 more source

Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae. [PDF]

, 2011
Caveolae are flask-shaped invaginations in the plasma membrane that serve to compartmentalize and organize signal transduction processes, including signals mediated by G protein-coupled receptors and heterotrimeric G proteins.
H.A. Katus, H.J. Hippe, I. Abu-Taha, N.M. Wolf, S. Just, S. Le Lay, S. Lutz, T. Wieland, W. Rottbauer   +8 more
core   +3 more sources

Real-time visualization of heterotrimeric G protein Gq activation in living cells

BMC Biology, 2011
Background Gq is a heterotrimeric G protein that plays an important role in numerous physiological processes. To delineate the molecular mechanisms and kinetics of signalling through this protein, its activation should be measurable in single living ...
Manders Erik MM, Nijmeijer Saskia, van Weeren Laura, Goedhart Joachim, Adjobo-Hermans Merel JW, Offermanns Stefan, Gadella Theodorus WJ   +6 more
doaj   +1 more source

Massive Sampling Strategy for Antibody–Antigen Targets in CAPRI Round 55 With MassiveFold

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Massive sampling with AlphaFold2 improves protein–protein complex predictions. This has been shown during the last CASP15‐CAPRI blind prediction round by the AFsample tool. However, more difficult targets including antibody–antigen binding remain challenging. CAPRI Round 55 consisted of three antibody–antigen targets and one heterotrimer.
Nessim Raouraoua, Marc F. Lensink, Guillaume Brysbaert   +2 more
wiley   +1 more source

Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces [PDF]

, 2017
G protein-coupled receptors (GPCRs) regulate cellular signalling through heterotrimeric G proteins and arrestins in response to an array of extracellular stimuli.
Carpenter, Byron, Tate, Christopher G.
core   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish [PDF]

, 2016
Photoreceptors are highly specialized sensory neurons that possess a modified primary cilium called the outer segment. Photoreceptor outer segment formation and maintenance require highly active protein transport via a process known as intraflagellar ...
Akhtar, Alfinito, Avasthi, Bachmann-Gagescu, Baker, Beech, Brockerhoff, Cao, Deacon, Eblimit, Goetz, Huang, Insinna, Insinna, Insinna, Jiang, Jimeno, Jimeno, Kodani, Krock, Lopes, Louie, Makhankov, Marszalek, Marszalek, Muresan, Muresan, Nascimento, Nonaka, Pazour, Ryan, Scholey, Shu, Stearns, Sukumaran, Traverso, Trivedi, Tsujikawa, Tuma, Westerfield, Whitehead, Wolfrum, Yamazaki, Yang, Zhao   +44 more
core   +2 more sources