Results 1 to 10 of about 254,808 (222)
HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning [PDF]
Drug Delivery, 2023 Organophosphorus agents, also known as nerve agents, are very dangerous chemicals that were used as chemical warfare agents. HI-6 is one of the most promising reactivators which is effective in reactivating AChE inhibited by many nerve agents.
Liao Shen +5 more
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Neurobiology of Disease, 2021 The result of a deprivation of oxygen and glucose to the brain, hypoxic–ischemic encephalopathy (HIE), remains the most common cause of death and disability in human neonates globally and is mediated by glutamate toxicity and inflammation.
O. Arteaga Cabeza +9 more
doaj +1 more source
Protective effect of HI-6 and trimedoxime combination in mice acutely poisoned with tabun, dichlorvos or heptenophos [PDF]
Acta Veterinaria, 2012 The aim of this study was to compare the protective effect of two individual oximes (HI-6 and trimedoxime) with their combination in mice acutely poisoned with tabun, dichlorvos or heptenophos.
Antonijević Biljana +2 more
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Ibrain, 2022 This study aimed to investigate the role of interleukin‐6 (IL‐6) in the pathogenesis of neonatal hypoxic‐ischemic encephalopathy (NHIE). Sprague‐Dawley (SD) rats were used for the establishment of hypoxic‐ischemic (HI) model.
Xiu Yang +3 more
doaj +1 more source
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source
Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice
Acta Medica, 2018 Aim: The influence of the dose on the ability of promising newly prepared reversible inhibitor of acetylcholinesterase (6-chlorotacrine) to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was ...
Jiří Kassa, Jan Korábečný
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The Alpha 7 Nicotinic Acetylcholine Receptor Does Not Affect Neonatal Brain Injury
Biomedicines, 2022 Inflammation plays a central role in the development of neonatal brain injury. The alpha 7 nicotinic acetylcholine receptor (α7nAChR) can modulate inflammation and has shown promising results as a treatment target in rodent models of adult brain injury ...
Maria E. Hammarlund +10 more
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Hydronephrosis Index as a New Method for the Evaluation and Follow-up of Fetal Hydronephrosis [PDF]
Iranian Journal of Neonatology, 2020 Background: The present study was conducted to compare the efficiency of hydronephrosis index (HI) with those of pelvic anteroposterior (AP) diameter and parenchymal thickness in the diagnosis of fetal hydronephrosis in the prenatal period, as well as 1,
Farideh Gharekhanloo
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BMC Pharmacology and Toxicology, 2018 Background The aim of our study was to compare the ability of two combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) with atropine to counteract acute sarin-induced brain damage with the efficacy of antidotal treatment involving single oxime (HI-
Filip Caisberger +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Inflammation and neonatal hypoxia-ischemia (HI) are important etiological factors of perinatal brain injury. However, underlying mechanisms remain unclear.
Gagandeep Singh-Mallah +11 more
doaj +1 more source