Results 51 to 60 of about 243,805 (237)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Genome Biology, 2022 Background Chromatin contacts are essential for gene-expression regulation; however, obtaining a high-resolution genome-wide chromatin contact map is still prohibitively expensive owing to large genome sizes and the quadratic scale of pairwise data ...
Ruchi Lohia, Nathan Fox, Jesse Gillis
doaj +1 more source
Detecting community structures in Hi-C genomic data [PDF]
2016 Annual Conference on Information Science and Systems (CISS), 2016 Community detection (CD) algorithms are applied to Hi-C data to discover new communities of loci in the 3D conformation of human and mouse DNA. We find that CD has some distinct advantages over pre-existing methods: (1) it is capable of finding a variable number of communities, (2) it can detect communities of DNA loci either adjacent or distant in the
Irineo Cabreros +2 more
openaire +2 more sources
Learning Micro-C from Hi-C with diffusion models.
PLoS Computational BiologyIn the last few years, Micro-C has shown itself as an improved alternative to Hi-C. It replaced the restriction enzymes in Hi-C assays with micrococcal nuclease (MNase), resulting in capturing nucleosome resolution chromatin interactions.
Tong Liu, Hao Zhu, Zheng Wang
doaj +1 more source
Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure
Epigenetics, 2019 DNA molecules are highly compacted in the eukaryotic nucleus where distal regulatory elements reach their targets through three-dimensional chromosomal interactions.
Yue Hou +6 more
doaj +1 more source
BMC Urology, 2020 Background The four most commonly-mutated genes in clear cell renal cell carcinoma (ccRCC) tumors are BAP1, PBRM1, SETD2 and VHL. And, there are currently 14 known RCC germline variants that have been reproducibly shown to be associated with RCC risk ...
Jeanette E. Eckel-Passow +9 more
doaj +1 more source
Stabilization by fusion to the C-terminus of hyperthermophile Sulfolobus tokodaii RNase HI: a possibility of protein stabilization tag. [PDF]
PLoS ONE, 2011 RNase HI from the hyperthermophile Sulfolobus tokodaii (Sto-RNase HI) is stabilized by its C-terminal residues. In this work, the stabilization effect of the Sto-RNase HI C-terminal residues was investigated in detail by thermodynamic measurements of the
Kazufumi Takano +6 more
doaj +1 more source
Structural Refinement by Direct Mapping Reveals Assembly Inconsistencies near Hi-C Junctions
Plants, 2023 High-throughput chromosome conformation capture (Hi-C) is widely used for scaffolding in de novo assembly because it produces highly contiguous genomes, but its indirect statistical approach can introduce connection errors.
Luca Marcolungo +10 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
NeoHiC: A Web Application for the Analysis of Hi-C Data [PDF]
, 2020 High-throughput sequencing Chromosome Conformation Capture (Hi-C) allows the study of chromatin interactions and 3D chromosome folding on a larger scale. A graph-based multi-level representation of Hi-C data is essential for proper visualisation of the spatial pattern they represent, in particular for comparing different experiments or for re-mapping ...
D'Agostino D +3 more
openaire +6 more sources