Results 61 to 70 of about 20,056,738 (185)
Single‐Cell Hi‐C Technologies and Computational Data Analysis
Advanced ScienceSingle‐cell chromatin conformation capture (scHi‐C) techniques have evolved to provide significant insights into the structural organization and regulatory mechanisms in individual cells.
Madison A Dautle, Yong Chen
doaj +1 more source
Learning Micro-C from Hi-C with diffusion models.
PLoS Computational BiologyIn the last few years, Micro-C has shown itself as an improved alternative to Hi-C. It replaced the restriction enzymes in Hi-C assays with micrococcal nuclease (MNase), resulting in capturing nucleosome resolution chromatin interactions.
Tong Liu, Hao Zhu, Zheng Wang
doaj +1 more source
Detecting community structures in Hi-C genomic data [PDF]
2016 Annual Conference on Information Science and Systems (CISS), 2016 Community detection (CD) algorithms are applied to Hi-C data to discover new communities of loci in the 3D conformation of human and mouse DNA. We find that CD has some distinct advantages over pre-existing methods: (1) it is capable of finding a variable number of communities, (2) it can detect communities of DNA loci either adjacent or distant in the
Irineo Cabreros +2 more
openaire +2 more sources
, 2023 Dependencies AMReX: release 23.05 openPMD-api: release 0.15.1 What's Changed CI: macOS Only One by @ax3l in https://github.com/Hi-PACE/hipace/pull/881 On dev branch, we build on top of amrex dev branch by @MaxThevenet in https://github.com/Hi-PACE ...
Lehe, Remi +6 more
core +1 more source
Stabilization by fusion to the C-terminus of hyperthermophile Sulfolobus tokodaii RNase HI: a possibility of protein stabilization tag. [PDF]
PLoS ONE, 2011 RNase HI from the hyperthermophile Sulfolobus tokodaii (Sto-RNase HI) is stabilized by its C-terminal residues. In this work, the stabilization effect of the Sto-RNase HI C-terminal residues was investigated in detail by thermodynamic measurements of the
Kazufumi Takano +6 more
doaj +1 more source
NeoHiC: A Web Application for the Analysis of Hi-C Data [PDF]
, 2020 High-throughput sequencing Chromosome Conformation Capture (Hi-C) allows the study of chromatin interactions and 3D chromosome folding on a larger scale. A graph-based multi-level representation of Hi-C data is essential for proper visualisation of the spatial pattern they represent, in particular for comparing different experiments or for re-mapping ...
D'Agostino D +3 more
openaire +8 more sources
BMC Urology, 2020 Background The four most commonly-mutated genes in clear cell renal cell carcinoma (ccRCC) tumors are BAP1, PBRM1, SETD2 and VHL. And, there are currently 14 known RCC germline variants that have been reproducibly shown to be associated with RCC risk ...
Jeanette E. Eckel-Passow +9 more
doaj +1 more source
On the relation of phase separation and Hi-C maps to epigenetics [PDF]
Royal Society Open Science, 2019 Abstract The relationship between compartmentalisation of the genome and epigenetics is long and hoary. In 1928 Heitz defined heterochromatin as the largest differentiated chromatin compartment in eukaryotic nuclei. Müller’s (1930) discovery of position-effect variegation (PEV) went on to show that heterochromatin is ...
Singh, Prim B., Newman, Andrew G.
openaire +4 more sources
Hi-C library statistics for different datasets used in this paper.
, 2019 Mapped read pairs denote the total number of Hi-C read pairs aligned before mapping quality filtering. Intra-contig read pairs account for the read pairs where both the reads align to same contig and inter-contig read pairs account for the read pairs ...
Arang Rhie (7296419) +7 more
core +1 more source
Integrative characterization of G-Quadruplexes in the three-dimensional chromatin structure
Epigenetics, 2019 DNA molecules are highly compacted in the eukaryotic nucleus where distal regulatory elements reach their targets through three-dimensional chromosomal interactions.
Yue Hou +6 more
doaj +1 more source