Results 141 to 150 of about 18,911,331 (239)

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Sociology of Leisure: Risk and Leisure RLO

, 2010
This RLO is part of “Sociology of Leisure” course. The module discusses some major features of current leisure patterns, but these activities are also central to modern life itself and thus have interests for sociologists.
Dr Dave Harris, MARJON
core  

Inflammasome Dynamics in the High-Risk Clone ST235 with Altered Pyoverdine Structures. [PDF]

Int J Mol Sci
Tanyolaç ZG.
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Impact of Ceftazidime-Avibactam Treatment in the Emergence of Novel KPC Variants in the ST307-Klebsiella pneumoniae High-Risk Clone and Consequences for Their Routine Detection. [PDF]

J Clin Microbiol, 2022
Hernández-García M, Castillo-Polo JA, Cordero DG, Pérez-Viso B, García-Castillo M, Saez de la Fuente J, Morosini MI, Cantón R, Ruiz-Garbajosa P.   +8 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Correction: KpFhaB/FhaC is a virulence-associated TPS system of the globally-disseminated <i>Klebsiella pneumoniae</i> ST15 high-risk clone. [PDF]

Front Cell Infect Microbiol
Tajuelo A, Gato E, Moya C, Prieto Martín-Gil S, Cano-Castaño B, Vaughan L, Miguela-Villoldo P, Pérez-Vázquez M, Moscoso M, Rodiño-Janeiro BK, Docando F, Terrón MC, Martín-Galiano AJ, McConnell MJ, Bou G, Pérez A.   +15 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

KpFhaB/FhaC is a virulence-associated TPS system of the globally-disseminated <i>Klebsiella pneumoniae</i> ST15 high-risk clone. [PDF]

Front Cell Infect Microbiol
Tajuelo A, Gato E, Moya C, Prieto Martín-Gil S, Cano-Castaño B, Vaughan L, Miguela-Villoldo P, Pérez-Vázquez M, Moscoso M, Rodiño-Janeiro BK, Docando F, Terrón MC, Martín-Galiano AJ, McConnell MJ, Bou G, Pérez A.   +15 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source