Results 1 to 10 of about 1,531 (135)

Emergence and regional spread of extended-spectrum β-lactamase-producing Klebsiella pneumoniae ST307 at a Japanese tertiary-care hospital [PDF]

Microbiology Spectrum
The global emergence of extended-spectrum β-lactamase-producing Klebsiella pneumoniae (ESBL-Kp), especially antimicrobial-resistant high-risk clones, is a public health concern. However, data on their molecular epidemiology in Japan remain limited.
Kei Kasahara, Yuki Suzuki, Akiyo Nakano
exaly   +5 more sources

Rectal Carriage of Sequence Type 307 Klebsiella pneumoniae High‐Risk Clone Harboring Multiple Carbapenemase Genes in Community Hospitals Gauteng, South Africa [PDF]

MicrobiologyOpen
Asymptomatic rectal carriers are recognized as reservoirs of carbapenem‐resistant Klebsiella pneumoniae (CRKp), which can spread epidemic high‐risk clones [e.g., sequence types (ST)‐307] and plasmids [incompatibility group (Inc)‐X3] in hospitals, with ...
Kafilat Taiwo Salvador‐Oke, Johann Pitout, Gisele Peirano, Kathy‐Anne Strydom, Chanel Kingsburgh, Marthie Ehlers, Marleen Kock   +6 more
doaj   +4 more sources

Klebsiella pneumoniae ST307 with blaOXA-181, South Africa, 2014-2016. [PDF]

Emerging Infectious Diseases, 2019
Klebsiella pneumoniae sequence type (ST) 307 is an emerging global antimicrobial drug–resistant clone. We used whole-genome sequencing and PCR to characterize K.
Liang Chen, Michelle Lowe, Marleen M Kock   +2 more
exaly   +4 more sources

Outbreak of NDM-5-producing Klebsiella pneumoniae ST307: an emerging high-risk antimicrobial resistance clone in Shanghai, China.

MSystems
The high-risk clone Klebsiella pneumoniae ST307, associated with various carbapenem resistance genes, exhibits a global distribution and prevalence. However, in China, it has remained sporadic and has rarely been detected.
Junying Zhu
exaly   +4 more sources

Convergence of multidrug resistance and efflux-mediated biocide tolerance in klebsiella pneumoniae ST307: implications for nosocomial infection control in Iranian hospitals [PDF]

BMC Infectious Diseases
Background The relentless evolution of K. pneumoniae ST307 into a “superbug” with dual resistance to last-line antibiotics and hospital disinfectants poses an existential threat to infection control.
Rezvan Goodarzi, Sima Kazemi, Mohammad Hossein Nasershariati, Babak Asghari   +3 more
doaj   +3 more sources

Comparative and Subtractive Genomics Analysis of Multidrug-Resistant <i>Klebsiella pneumoniae</i> Strains for Novel Target Identification and Drug Repurposing Strategies. [PDF]

Int J Microbiol
The rapid rise of multidrug‐resistant (MDR) Klebsiella pneumoniae has created a major global health challenge due to the limited availability of conserved therapeutic targets effective across diverse resistant strains. In this study, an integrative computational target‐discovery and drug‐repurposing framework was applied to six clinically relevant K ...
Bora M, Paul P, Rajkhowa S, Sonar H, Gohain BB, Zaki MEA, Prabhu D.   +6 more
europepmc   +2 more sources

Addressing therapeutic options for KPC-3-producing ST307-Klebsiella pneumoniae: insights from in vitro evolution and mutant prevention strategies [PDF]

Antimicrobial Agents and Chemotherapy
Ceftazidime-avibactam, meropenem-vaborbactam, and imipenem-relebactam are key therapeutic options for infections caused by KPC-producing Klebsiella pneumoniae (KPC-Kp).
Marta Hernández-García, Blanca Pérez-Viso, Marta Nieto-Torres, María García-Castillo, Malkoa Michelena, Luis Martínez-Martínez, Fernando Baquero, Patricia Ruiz-Garbajosa, Rafael Cantón   +8 more
doaj   +2 more sources

Multidrug-Resistant Pathogen Clonal Spread in Nigeria: A Systematic Review and Meta-Analysis. [PDF]

Health Sci Rep
ABSTRACT Background and Aim The rapid dissemination of multidrug‐resistant (MDR) bacterial clones poses a global health threat and limits treatment options. Understanding the dynamics of bacterial clones in Nigeria is essential for developing effective control strategies. This systematic review aimed to track MDR pathogen clones in Nigeria. Methods The
Ugbo EN, Afiukwa FN, Effendi MH, Darkwah S, Odoom A, Donkor ES.   +5 more
europepmc   +2 more sources

Exploratory Genomic Characterisation of the Resistome, Virulome and Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Clinical Isolates from Four Peruvian Regions [PDF]

Microorganisms
Multidrug-resistant (MDR) Klebsiella pneumoniae is a critical cause of nosocomial infections associated with high mortality. Of particular concern is the genomic convergence of multidrug resistance and hypervirulence (MDR-hvKP), which represents a severe
Karen Quispe Oré, Alberto Salazar-Granara, Mario Cueva Távara, Janet Huancachoque Molina, Diego Segura-Loayza, Daisy Obispo Achallma, Guillermo Liendo Aguirre, Antonio Burgos Espejo, Alexander Briones Alejos, Sheyber Lifonzo Mucha, Teresa Alarcón-Castillo, Pool Marcos-Carbajal   +11 more
doaj   +2 more sources

Companion Animals Harbour Globally Circulating Human-Associated Klebsiella pneumoniae Lineages and High-Risk Antimicrobial Resistance Clones. [PDF]

Transbound Emerg Dis
Companion animals are increasingly recognised within One Health antimicrobial‐resistance (AMR) surveillance, yet the global genomic structure of dog‐ and cat‐associated Klebsiella pneumoniae remains poorly defined. We assembled a global dataset of 712 domestic dog (Canis lupus familiaris)– and cat (Felis catus)–derived K.
Fordham SME, Sheridan E, Drobniewski F.
europepmc   +2 more sources