Results 21 to 30 of about 229,438 (321)
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]
, 2015 Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Alonso-Padilla, Julio +20 more
core +3 more sources
High-Throughput Screening to Predict Chemical-Assay Interference [PDF]
Scientific Reports, 2020 AbstractThe U.S. federal consortium on toxicology in the 21st century (Tox21) produces quantitative, high-throughput screening (HTS) data on thousands of chemicals across a wide range of assays covering critical biological targets and cellular pathways.
Alexandre Borrel +8 more
openaire +2 more sources
RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes. [PDF]
, 2017 Synthetic biology and metabolic engineering seek to re-engineer microbes into living foundries for the production of high value chemicals. Through a design-build-test cycle paradigm, massive libraries of genetically engineered microbes can be constructed
Abate, Adam +8 more
core +1 more source
Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni [PDF]
, 2015 Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple ...
Altamura, Sergio +5 more
core +9 more sources
STAR Protocols, 2021 Summary: Autophagy measurement has been challenging due to the transient nature of autophagy vesicles, in which degradation of cargo occurs. Here, we present a protocol to monitor starvation-induced autophagy using a live high-throughput microscopy ...
Ada Nowosad, Arnaud Besson
doaj +1 more source
An image analysis toolbox for high-throughput C. elegans assays [PDF]
, 2011 We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems.
AE Carpenter +35 more
core +1 more source
STAR Protocols, 2023 Summary: The complement receptors C3aR and C5aR1 are promising therapeutic targets. Here, we present a protocol to screen the effects of different agonists and antagonists on these receptors in vitro, using phosphorylated extracellular signal-regulated ...
Xaria X. Li, Trent M. Woodruff
doaj +1 more source
In-silico Predictive Mutagenicity Model Generation Using Supervised Learning Approaches [PDF]
, 2011 With the advent of High Throughput Screening techniques, it is feasible to filter possible leads from a mammoth chemical space that can act against a particular target and inhibit its action.
Abhik Seal +4 more
core +2 more sources
Semiconductor Electronic Label-Free Assay for Predictive Toxicology. [PDF]
, 2016 While animal experimentations have spearheaded numerous breakthroughs in biomedicine, they also have spawned many logistical concerns in providing toxicity screening for copious new materials. Their prioritization is premised on performing cellular-level
Chui, Chi On +5 more
core +2 more sources
Alginate-based 3D cancer cell culture for therapeutic response modeling
STAR Protocols, 2021 Summary: Two-dimensional (2D) culture of tumor cells fails to recapitulate some important aspects of cellular organization seen in in vivo experiments. In addition, cell cultures traditionally use non-physiological concentration of nutrients.
Farideh Davoudi +9 more
doaj +1 more source