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Leveraging Interactions in Microfluidic Droplets for Enhanced Biotechnology Screens [PDF]
Current Opinion in Biotechnology, August 2023, Volume 82, 102966, 2023 Microfluidic droplet screens serve as an innovative platform for high-throughput biotechnology, enabling significant advancements in discovery, product optimization, and analysis. This review sheds light on the emerging trend of interaction assays in microfluidic droplets, underscoring the unique suitability of droplets for these applications ...
arxiv +1 more source
Cytometry of raft and caveola membrane microdomains: From flow and imaging techniques to high throughput screening assays [PDF]
Cytometry Part A, 2008 Еndre Kiss +4 more
openalex +2 more sources
Scientific Reports, 2021 Neuronal models are a crucial tool in neuroscientific research, helping to elucidate the molecular and cellular processes involved in disorders of the nervous system.
Anusha Dravid +3 more
semanticscholar +1 more source
Journal of biomolecular screening, 1999 The ability to identify active compounds ("hits") from large chemical libraries accurately and rapidly has been the ultimate goal in developing high-throughput screening (HTS) assays.
Ji-Hu Zhang, T. Chung, K. Oldenburg
semanticscholar +1 more source
Ammonia-induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis [PDF]
ACS Applied Materials & Interfaces Manuscript ID:
am-2021-004953.R2, 2021 Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective therapeutic solutions for those diseases. Here we reported the development of a novel and robust nano-structured calcium
arxiv +1 more source
Principal component-based image segmentation: a new approach to outline in vitro cell colonies [PDF]
Computer Methods in Biomechanics and Biomedical Engineering:
Imaging & Visualization (2022), 2021 The in vitro clonogenic assay is a technique to study the ability of a cell to form a colony in a culture dish. By optical imaging, dishes with stained colonies can be scanned and assessed digitally. Identification, segmentation and counting of stained colonies play a vital part in high-throughput screening and quantitative assessment of biological ...
arxiv +1 more source
Frontiers in Microbiology, 2023 Neisseria gonorrhoeae (gonococcus) is an obligate human pathogen and the etiological agent of the sexually transmitted disease gonorrhea. The rapid rise in gonococcal resistance to all currently available antimicrobials has become a significant public ...
Samuele Stazzoni +7 more
doaj +1 more source
Compound virtual screening by learning-to-rank with gradient boosting decision tree and enrichment-based cumulative gain [PDF]
In Proceedings of The 19th IEEE International Conference on
Computational Intelligence in Bioinformatics and Computational Biology (CIBCB
2022), 2022 Learning-to-rank, a machine learning technique widely used in information retrieval, has recently been applied to the problem of ligand-based virtual screening, to accelerate the early stages of new drug development. Ranking prediction models learn based on ordinal relationships, making them suitable for integrating assay data from various environments.
arxiv +1 more source
A promising approach for the real-time quantification of cytosolic protein-protein interactions in living cells [PDF]
, 2020 In recent years, cell-based assays have been frequently used in molecular interaction analysis. Cell-based assays complement traditional biochemical and biophysical methods, as they allow for molecular interaction analysis, mode of action studies and even drug screening processes to be performed under physiologically relevant conditions.
arxiv +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Schistosomiasis is a parasitic neglected disease with praziquantel (PZQ) utilized as the main drug for treatment, despite its low effectiveness against early stages of the worm. To aid in the search for new drugs to tackle schistosomiasis, computer-aided
Bernardo Pereira Moreira +7 more
doaj +1 more source