Radon Emanation Techniques and Measurements for LZ [PDF]
arXiv, 2022 Radon emanation was projected to account for $>50$% of the electron recoil background in the WIMP region of interest for the LUX-ZEPLIN (LZ) experiment. To mitigate the amount of radon inside the detector volume, materials with inherently low radioactivity content were selected for LZ construction through an extensive screening campaign.
arxiv
Assessment of protein inclusions in cultured cells using automated image analysis
STAR Protocols, 2022 Summary: Proteinaceous inclusions are associated with neurodegenerative diseases and cell models are often used to determine genetic and chemical modifiers of their formation.
Luke McAlary +6 more
doaj
Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics [PDF]
arXiv, 2020 The recent global pandemic of Coronavirus Disease 2019 (COVID-19) caused by the new coronavirus SARS-CoV-2 presents an urgent need for new therapeutic candidates. Many efforts have been devoted to screening existing drug libraries with the hope to repurpose approved drugs as potential treatments for COVID-19. However, the antiviral mechanisms of action
arxiv
Alginate-based 3D cancer cell culture for therapeutic response modeling
STAR Protocols, 2021 Summary: Two-dimensional (2D) culture of tumor cells fails to recapitulate some important aspects of cellular organization seen in in vivo experiments. In addition, cell cultures traditionally use non-physiological concentration of nutrients.
Farideh Davoudi +9 more
doaj
Spectrophotometric Enzyme Assays for High-Throughput Screening
Food Technology and Biotechnology, 2004 This paper reviews high-throughput screening enzyme assays developed in our laboratory over the last ten years. These enzyme assays were initially developed for the purpose of discovering catalytic antibodies by screening cell culture supernatants, but ...
Jean-Louis Reymond
doaj
Toxicity profiling of engineered nanomaterials via multivariate dose-response surface modeling [PDF]
Annals of Applied Statistics 2012, Vol. 6, No. 4, 1707-1729, 2013 New generation in vitro high-throughput screening (HTS) assays for the assessment of engineered nanomaterials provide an opportunity to learn how these particles interact at the cellular level, particularly in relation to injury pathways. These types of assays are often characterized by small sample sizes, high measurement error and high dimensionality,
arxiv +1 more source
Design of Signal Windows in High Throughput Screening Assays for Drug Discovery
, 1997 High Throughput Screening (HTS) assays are used to rapidly identify promising drug candidates or leads from hundreds of thousands of compounds. Hence, it is important that the assay should be designed to discriminate responses from the active and ...
G. Sittampalam +7 more
semanticscholar +1 more source
Versatile assays for high throughput screening for activators or inhibitors of intracellular proteases and their cellular regulators. [PDF]
PLoS ONE, 2009 BACKGROUND:Intracellular proteases constitute a class of promising drug discovery targets. Methods for high throughput screening against these targets are generally limited to in vitro biochemical assays that can suffer many technical limitations, as ...
Hideki Hayashi +11 more
doaj +1 more source
Predictive Correlation Screening: Application to Two-stage Predictor Design in High Dimension [PDF]
arXiv, 2013 We introduce a new approach to variable selection, called Predictive Correlation Screening, for predictor design. Predictive Correlation Screening (PCS) implements false positive control on the selected variables, is well suited to small sample sizes, and is scalable to high dimensions.
arxiv
Protocol for tissue slice cultures from human solid tumors to study therapeutic response
STAR Protocols, 2021 Summary: The impact of systemic therapy on the tumor microenvironment has been difficult to study in human solid tumors. Our protocol describes steps for establishing slice cultures to investigate response to chemotherapies, immunotherapies, or adoptive ...
Heidi L. Kenerson +4 more
doaj