A Hippo signal for anoikis [PDF]
Nature Reviews Molecular Cell Biology, 2012 openaire +1 more source
The FEBS Journal, EarlyView.MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz +13 more
wiley +1 more source
The emerging role of the Hippo signaling pathway in interorgan crosstalk
The FEBS Journal, EarlyView.Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song +2 more
wiley +1 more source
Loss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation. [PDF]
Cell Death DisMiah M +14 more
europepmc +1 more source
Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells
The FEBS Journal, EarlyView.MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe +5 more
wiley +1 more source
Hippo signaling pathway in polycystic ovary syndrome. [PDF]
Front Endocrinol (Lausanne)Wen J, Cheng G, Zhang Y, Liu S.
europepmc +1 more source
Hippo pathway disruption and YAP1 activation in anogenital papillary squamous intraepithelial lesion
Histopathology, EarlyView.Disruption of the Hippo Pathway with YAP1 activation is a consistent finding in papillary squamous intraepithelial lesions and may underlie their altered epithelial maturation and HPV E6/E7 expression patterns, providing new insight into the pathogenesis of this distinct low‐risk HPV‐associated lesion.
Gloria Zhang +4 more
wiley +1 more source
Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs. [PDF]
Nat CommunZhang K +6 more
europepmc +1 more source
Doctrine, Narrative and the Formation of Christian Identity: A Conversation with Alister McGrath
International Journal of Systematic Theology, EarlyView.Abstract This article offers a critical and appreciative response to Alister McGrath’s The Nature of Christian Doctrine, exploring the formation of doctrine as a dynamic communal process rooted in Scripture, liturgy and historical context. It highlights McGrath’s analogy between doctrinal development and scientific method, emphasising the search for a ...
Frances Margaret Young
wiley +1 more source
Chidamide and Anlotinib act synergistically in Jurkat cells by inhibiting the Hippo signaling pathway. [PDF]
Biochem Biophys RepMa T +6 more
europepmc +1 more source