Results 161 to 170 of about 60,559 (303)
Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease
iNew Medicine, EarlyView.Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer. It is essential to understand the role of ALD to prevent
Boyu Zhang +5 more
wiley +1 more source
Global Warming and Mass Extinctions Associated With Large Igneous Province Volcanism
Geophysical Monograph Series, Page 83-102., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
David P. G. Bond, Yadong Sun
wiley +1 more source
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Journal of Quaternary Science, EarlyView.Abstract The transition from the Last Glacial Maximum to the Late Glacial marked a shift from the cold conditions of Greenland Stadial‐2 (GS‐2) to the warmer phases of Greenland Interstadial‐1 (GI‐1), enabling the reoccupation of Alpine regions by Late Palaeolithic hunter‐gatherers.
Mahym Amanova +2 more
wiley +1 more source
Molecular Carcinogenesis, EarlyView.ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha +26 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He +2 more
wiley +1 more source
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, EarlyView.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
SnapShot: The Hippo Signaling Pathway
Cell, 2011 Badouel, Caroline, McNeill, Helen
openaire +2 more sources
From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies
Portal Hypertension &Cirrhosis, EarlyView.This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu +5 more
wiley +1 more source
Strategies for Assessing Post‐Wildfire Geomorphic Resilience in Semiarid Rivers
River Research and Applications, EarlyView.ABSTRACT We review and summarize diverse components of a catchment that can be monitored after wildfire to assess the geomorphic resilience of the river corridor in semiarid regions. We distinguish upland portions of river catchments from river corridors.
Ellen Wohl +8 more
wiley +1 more source