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Adult Hippocampal Neurogenesis: A Possible Way how Physical Exercise Counteracts Stress [PDF]

Cell Transplantation, 2011
It was considered that neurogenesis only occurred during the embryonic and developmental stage. This view has greatly changed since the discovery of adult neurogenesis in two brain regions: the hippocampus and the olfactory bulb.
Suk-Yu Yau, Benson Wui-Man Lau, Kwok-Fai So   +2 more
doaj   +2 more sources

Research progress on hippocampal neurogenesis in autism spectrum disorder [PDF]

Pediatric Investigation
Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders with unclear etiology and significant heterogeneity that is emerging as a global public health concern.
Mengxiang Chen, Lanmin Guo, Qinghong Li, Shunbo Yang, Wei Li, Yanmei Lai, Zhihai Lv   +6 more
doaj   +2 more sources

What Is the Relationship Between Hippocampal Neurogenesis Across Different Stages of the Lifespan?

Frontiers in Neuroscience, 2022
Hippocampal neurogenesis has typically been studied during embryonic development or in adulthood, promoting the perception of two distinct phenomena.
Allison M. Bond, Guo-li Ming, Guo-li Ming, Guo-li Ming, Guo-li Ming, Hongjun Song, Hongjun Song, Hongjun Song, Hongjun Song   +8 more
doaj   +1 more source

IL-1β and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus

Journal of Neuroinflammation, 2021
Background The dentate gyrus exhibits life-long neurogenesis of granule-cell neurons, supporting hippocampal dependent learning and memory. Both temporal lobe epilepsy patients and animal models frequently have hippocampal-dependent learning and memory ...
Malik Zaben, Niels Haan, Feras Sharouf, Aminul Ahmed, Lars E. Sundstrom, William P. Gray   +5 more
doaj   +1 more source

Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question

Frontiers in Molecular Neuroscience, 2021
Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal memory formation. Several studies associated altered hippocampal neurogenesis with aging and Alzheimer's disease (AD).
Domenica Donatella Li Puma, Domenica Donatella Li Puma, Roberto Piacentini, Roberto Piacentini, Claudio Grassi, Claudio Grassi   +5 more
doaj   +1 more source

Cholinergic and Neuroimmune Signaling Interact to Impact Adult Hippocampal Neurogenesis and Alcohol Pathology Across Development

Frontiers in Pharmacology, 2022
Alcohol (ethanol) use and misuse is a costly societal issue that can affect an individual across the lifespan. Alcohol use and misuse typically initiates during adolescence and generally continues into adulthood.
Victoria A. Macht, Ryan P. Vetreno, Ryan P. Vetreno, Fulton T. Crews, Fulton T. Crews, Fulton T. Crews   +5 more
doaj   +1 more source

Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics

Frontiers in Immunology, 2023
Adult hippocampal neurogenesis generates functional neurons from neural progenitor cells in the hippocampal dentate gyrus (DG) to complement and repair neurons and neural circuits, thus benefiting the treatment of depression.
Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Chen, Jiaxu Chen   +14 more
doaj   +1 more source

Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]

, 2020
Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core   +1 more source

Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage

Neurobiology of Disease, 2008
It has not been reported whether thiamine deficiency (TD) affects hippocampal neurogenesis or not. Here, we explored the influence of TD at early pre-pathological lesion stage on hippocampal neurogenesis and the correlation between affected hippocampal ...
Na Zhao, Chunjiu Zhong, Yang Wang, Yanling Zhao, Neng Gong, Guomin Zhou, Tianle Xu, Zhen Hong   +7 more
doaj   +1 more source

Modeling Reveals the Dependence of Hippocampal Neurogenesis Radiosensitivity on Age and Strain of Rats [PDF]

, 2018
Cognitive dysfunction following radiation treatment for brain cancers in both children and adults have been correlated to impairment of neurogenesis in the hippocampal dentate gyrus.
Cacao, Eliedonna, Cucinotta, Francis A., Kapukotuwa, Sidath   +2 more
core   +3 more sources