Morris Water Maze Learning in Two Rat Strains Increases the Expression of the Polysialylated Form of the Neural Cell Adhesion Molecule in the Dentate Gyrus But Has No Effect on Hippocampal Neurogenesis [PDF]
, 2005 In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus.
Borght, Karin van der, +4 more
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Serotonin and Hippocampal Neurogenesis [PDF]
Neuropsychopharmacology, 1999 The dentate gyrus continues to produce new granule neurons well into adulthood. This has been demonstrated for many mammalian species, from rodents to primates. The proliferation of granule cell precursors can be suppressed by stressful experiences, presumably via adrenal steroids.
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Role of adult hippocampal neurogenesis in stress resilience
Neurobiology of Stress, 2015 There is a growing appreciation that adult hippocampal neurogenesis plays a role in emotional and cognitive processes related to psychiatric disorders. Although many studies have investigated the effects of stress on adult hippocampal neurogenesis, most ...
Brunno R. Levone +2 more
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Local and regional heterogeneity underlying hippocampal modulation of cognition and mood. [PDF]
, 2014 While the hippocampus has been classically studied for its role in learning and memory, there is significant support for a role of the HPC in regulating emotional behavior.
Jimenez, Jessica C +2 more
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Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]
, 2020 Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B. +11 more
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Reconsidering hippocampal neurogenesis in Alzheimer's disease [PDF]
Frontiers in Neuroscience, 2014 Hippocampal neurogenesis is oftenthought to be necessary to maintainhippocampus-dependent cognitive abil-ities (see references in Deng et al., 2010).Most investigations using transgenic ani-mal models of Alzheimer’s disease (AD)report a reduction in hippocampal neu-rogenesis (see references in Mu and Gage,2011) giving rise to the idea that ...
Alonso eMartinez-Canabal +1 more
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Exercise-Mediated Neurogenesis in the Hippocampus via BDNF
Frontiers in Neuroscience, 2018 Exercise is known to have numerous neuroprotective and cognitive benefits, especially pertaining to memory and learning related processes. One potential link connecting them is exercise-mediated hippocampal neurogenesis, in which new neurons are ...
Patrick Z. Liu, Robin Nusslock
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IBRO Neuroscience Reports, 2022 Norepinephrine (NE), and specific adrenoceptors, have been reported to influence distinct aspects of adult hippocampal neurogenesis, including latent stem cell activation, progenitor proliferation, and differentiation.
Darshana Kapri +9 more
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The systemic environment: at the interface of aging and adult neurogenesis. [PDF]
, 2017 Aging results in impaired neurogenesis in the two neurogenic niches of the adult mammalian brain, the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle.
Smith, Lucas K +2 more
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Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]
, 2013 Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
A McQuillin +114 more
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