Results 41 to 50 of about 101,099 (274)

Disrupted Neurogenesis in Germ-Free Mice: Effects of Age and Sex

Frontiers in Cell and Developmental Biology, 2020
The gut microbiome has profound effects on development and function of the nervous system. Recent evidence indicates that disruption of the gut microbiome leads to altered hippocampal neurogenesis.
Gavin A. Scott, Dylan J. Terstege, Alex P. Vu, Sampson Law, Alexandria Evans, Jonathan R. Epp   +5 more
doaj   +1 more source

Sustained Activation of the Anterior Thalamic Neurons with Low Doses of Kainic Acid Boosts Hippocampal Neurogenesis

Cells, 2022
Adult hippocampal neurogenesis is prone to modulation by several intrinsic and extrinsic factors. The anterior nucleus (AN) of the thalamus has extensive connections with the hippocampus, and stimulation of this region may play a role in altering ...
Farah Chamaa, Batoul Darwish, Rami Arnaout, Ziad Nahas, Elie D. Al-Chaer, Nayef E. Saadé, Wassim Abou-Kheir   +6 more
doaj   +1 more source

Modulation of adult-born neurons in the inflamed hippocampus. [PDF]

, 2013
Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer,
Belarbi, Karim, Rosi, Susanna
core   +2 more sources

Depression and adult hippocampal neurogenesis

Folia Pharmacologica Japonica, 2010
現在，うつ病の治療薬はセロトニンやノルアドレナリンといったモノアミンを増加させる薬剤が中心として用いられているが，脳内の細胞外モノアミン濃度は抗うつ薬の投与数時間後には増加するのに対し，臨床における治療効果発現までには数週間の慢性投与が必要とされることもあり，抗うつ薬の治療発現メカニズムは未だ明らかとされていない．近年，成熟期の脳においても海馬歯状回といった特定領域において，神経幹・前駆細胞が存在し，神経細胞が新生されることが明らかにされている．この海馬における神経新生は，うつ病発症の危険因子とされるストレスによって抑制され，逆に抗うつ薬を慢性投与することによって促進される．さらに，海馬神経新生を阻害すると，行動薬理評価モデルにおける抗うつ薬の作用が消失するなどの報告から ...
Takahiro, Masuda, Shin, Nakagawa, Tsukasa, Koyama   +2 more
openaire   +3 more sources

Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability [PDF]

, 2017
Oligophrenin-1 (OPHN1) is a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID). How loss of function of Ophnl affects neuronal development is only partly understood.
Allegra, M, Azzimondi, S, Billuart, P, Busti, I, Caleo, M, Canossa, M, Spalletti, C, Vignoli, B   +7 more
core   +1 more source

Sirt6 alters adult hippocampal neurogenesis

PLOS ONE, 2017
Sirtuins are pleiotropic NAD+ dependent histone deacetylases involved in metabolism, DNA damage repair, inflammation and stress resistance. SIRT6, a member of the sirtuin family, regulates the process of normal aging and increases the lifespan of male mice over-expressing Sirt6 by 15%.
Eitan Okun, Daniel Marton, Daniel Cohen, Kathleen Griffioen, Yariv Kanfi, Tomer Illouz, Ravit Madar, Haim Y. Cohen   +7 more
openaire   +4 more sources

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in a mouse model of Alzheimer’s disease

Neural Regeneration Research
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease. Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.
Mackenzie M. Spicer, Jianqi Yang, Daniel Fu, Alison N. DeVore, Marisol Lauffer, Nilufer S. Atasoy, Deniz Atasoy, Rory A. Fisher   +7 more
doaj   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Intermittent hypoxia after transient focal ischemia induces hippocampal neurogenesis and c-Fos expression and reverses spatial memory deficits in rats. [PDF]

PLoS ONE, 2011
Memory impairment is a frequent complication of brain ischemia. Neurogenesis is implicated in learning and memory and is regulated by the transcription factor c-Fos. Preconditioning intermittent hypoxia (IH) attenuates ischemia-related memory impairments,
Yi-Wei Tsai, Yea-Ru Yang, Paulus S Wang, Ray-Yau Wang   +3 more
doaj   +1 more source

Stress Response and Hearing Loss Differentially Contribute to Dynamic Alterations in Hippocampal Neurogenesis and Microglial Reactivity in Mice Exposed to Acute Noise Exposure

Frontiers in Neuroscience, 2021
Noise-induced hearing loss (NIHL) is one of the most prevalent forms of acquired hearing loss, and it is associated with aberrant microglial status and reduced hippocampal neurogenesis; however, the nature of these associations is far from being ...
Qian Li, Hong Li, Xiuting Yao, Conghui Wang, Haiqing Liu, Dan Xu, Chenxi Yang, Hong Zhuang, Yu Xiao, Rui Liu, Sinuo Shen, Shaoyang Zhou, Chenge Fu, Yifan Wang, Gaojun Teng, Lijie Liu   +15 more
doaj   +1 more source