Results 111 to 120 of about 453,877 (390)

Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity.

Transplantation, 1997
BACKGROUND There is controversy in the literature as to whether swine coronary endothelium expresses major histocompatibility complex (MHC) class II antigens constitutively. METHODS Because this issue has implications for cell-mediated human anti-swine
J. Choo, J. Seebach, V. Nickeleit, A. Shimizu, H. Lei, D. Sachs, J. Madsen   +6 more
semanticscholar   +1 more source

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source

HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

مجلة كلية الطب, 2005
Summary: OBJECTIVE Many associations have been found between specific HLA antigens and increased susceptibility to various diseases . So we tried to associate class I and class II antigens with acute lymphoblastic leukemia .
BATOOL M. MAHDI, salalwa M. Shareef
doaj   +1 more source

Large-scale GPU-based network analysis of the human T-cell receptor repertoire [PDF]

arXiv, 2021
Understanding the structure of the human T-cell receptor repertoire is a crucial precondition to understand the ability of the immune system to recognize and respond to antigens. T-cells are often compared via the complementarity determining region 3 (CDR3) of their respective T-cell receptor beta chains.
arxiv  

Signal Recognition Particle-dependent Membrane Insertion of Mouse Invariant Chain: A Membrane-spanning Protein with a Cytoplasmically Exposed Amino Terminus [PDF]

, 1986
Invariant (Ii) chain is a membrane-spanning protein that is found associated intracellularly with class II histocompatibility antigens. In the endoplasmic reticulum Ii chain spans the membrane and exposes the NH2 terminus on the cytoplasmic and the COOH
Dobberstein, Bernhard, Lipp, Joachim
core   +1 more source

Preformed IgG antibodies against major histocompatibility complex class II antigens are major risk factors for high-grade cellular rejection in recipients of heart transplantation.

Circulation, 1998
BACKGROUND Preformed anti-HLA antibodies reacting specifically with donor lymphocytes have been associated with acute vascular rejection and early cardiac allograft failure. However, the effect of preformed anti-HLA antibodies directed against allogeneic
S. Itescu, T. Tung, E. Burke, A. Weinberg, N. Moazami, J. Artrip, N. Suciu-Foca, E. Rose, M. Oz, R. Michler   +9 more
semanticscholar   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells [version 1; referees: 4 approved]

F1000Research, 2016
T cell antigen receptors (TCRs) expressed on cytotoxic or helper T cells can only see their specific target antigen as short sequences of peptides bound to the groove of proteins of major histocompatibility complex (MHC) class I, and class II ...
Scheherazade Sadegh-Nasseri
doaj   +1 more source

Attention-aware contrastive learning for predicting T cell receptor-antigen binding specificity [PDF]

arXiv, 2022
It has been verified that only a small fraction of the neoantigens presented by MHC class I molecules on the cell surface can elicit T cells. The limitation can be attributed to the binding specificity of T cell receptor (TCR) to peptide-MHC complex (pMHC). Computational prediction of T cell binding to neoantigens is an challenging and unresolved task.
arxiv