Results 121 to 130 of about 453,877 (390)

Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells

Journal of Experimental Medicine, 1991
Antigen-presenting cells (APC) transfected with a construct encoding the hen egg-white lysozyme (HEL) amino acid sequence 1-80 constitutively present HEL peptides complexed to major histocompatibility complex (MHC) class II molecules to specific T cell ...
L. Adorini, J. Moreno, F. Momburg, G. Hämmerling, J. Guéry, A. Valli, S. Fuchs   +6 more
semanticscholar   +1 more source

Alloreactive lymphoid infiltrates in human heart transplants: Loss of class II-directed cytotoxicity more than 3 months after transplantation [PDF]

, 1991
From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant.
Baan, C.C. (Carla), Balk, A.H.M.M. (Aggie), Bos, E. (Egbert), Claas, F.H.J. (Frans), Essed, C.E. (Catherina), Jutte, N.H.P.M. (Nicolet), Ouwehand, A.J., Vaessen, L.M.B. (Leonard), Weimar, W. (Willem)   +8 more
core   +1 more source

Alkaline Adjuvant Regulates Proteolytic Activity of Macrophages for Antigen Cross‐Presentation and Potentiates Radioimmunotherapy

Advanced Materials, Volume 37, Issue 12, March 26, 2025.
Tissue‐repairing macrophages compromise radiotherapy‐induced antitumor immunity. An alkaline adjuvant (MgAl‐based hydrotalcite, bLDH) reverses the situation. After engendering macrophages to phagocytose irradiated cancer cells, bLDH is administrated and improves the cross‐presentation of engulfed tumor antigens over tenfold. bLDH limits the activity of
Bei Li, Yan Tan, Josh Haipeng Lei, Min Deng, Xinwang Yu, Xinyi Wang, Lek Man Lei, Lin He, Chu‐Xia Deng, Yunlu Dai   +9 more
wiley   +1 more source

Trans-allelic model for prediction of peptide:MHC-II interactions [PDF]

arXiv, 2017
Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, helper T cells mount an immune response against invading pathogens.
arxiv  

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]

, 1989
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G., Gekeler, V., Müller, C. A., Schmidt, H., Steiert, I., Weiss, Elisabeth H.   +5 more
core   +1 more source

Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation.

Journal of Immunology, 1986
Although class II antigens encoded by genes in the major histocompatibility complex (MHC) are important as recognition structures for immunoregulatory cell interactions, the precise functional role of these molecules in the biological responses of B ...
L. Clement, T. Tedder, G. Gartland
semanticscholar   +1 more source

Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma

Advanced Materials, Volume 37, Issue 16, April 23, 2025.
A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura, Alessio Malfanti, Ana I Matos, Carina Peres, Ana Armiñán, Aroa Duro‐Castaño, Inmaculada Conejos‐Sánchez, María Medel, Snežana Đorđević, Paula Carrascosa, Bárbara Carreira, Rita C Acúrcio, Helena Xavier‐Ferreira, Alberto Hernández‐Barranco, Elena Castellano, Esther Roselló, José C. Machado, Héctor Peinado, María J. Vicent, Helena F. Florindo   +19 more
wiley   +1 more source

A rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy

Acta Pharmaceutica Sinica B, 2023
Cancer vaccines represent a promising immunotherapeutic treatment modality. The promotion of cross-presentation of extracellular tumor-associated antigens on the major histocompatibility complex (MHC) class I molecules and dendritic cell maturation at ...
Aihua Wu, Afeng Yang, Qinli Tong, Guoguang Wei, Sihang Zhang, Sheng Yu, Chen Zhang, Jiaojiao Xu, Wei Lu   +8 more
doaj  

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. [PDF]

, 1994
Limited regions of amino acid sequence similarity frequently occur between microbial antigens and host proteins. It has been widely anticipated that during infection such sequence similarities could induce cross-reactive T cell responses, thereby ...
Kaufman, DL, Lehmann, PV, Tian, J
core  

A single amino acid substitution in the alpha 3 domain of an H-2 class I molecule abrogates reactivity with CTL. [PDF]

, 1987
We previously described a somatic cell expressing a variant H-2Dd molecule that did not serve as a target for alloreactive anti-Dd CTL. The mutant cell line had been isolated by its failure to express a serological epitope present on the H-2Dd alpha 3 ...
Bluestone, JA, Potter, TA, Rajan, TV
core   +2 more sources