Results 11 to 20 of about 453,877 (390)

Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells. [PDF]

Journal of Immunology, 1988
We have examined the effects of transforming growth factor-beta (TGF-beta 1) on the expression of the class II histocompatibility Ag, HLA-DR: 1) induced by human rIFN-gamma (rHuIFN-gamma) in human melanoma, Hs294T cells and 2) constitutively expressed in
Christine W. Czarniecki, Hsien Hung Chiu, G H Wong, Susan McCabe, Michael A. Palladino   +4 more
openalex   +2 more sources

Phagocytic processing of antigens for presentation by class II major histocompatibility complex molecules [PDF]

Cellular Microbiology, 1999
Microbes and other particulate antigens (Ags) are internalized by phagocytosis and then reside in plasma membrane-derived phagosomes. The contribution of phagosomes to the degradation of Ags has long been appreciated. It has been unclear, however, whether peptides derived from these degraded antigens bind class II major histocompatibility complex (MHC ...
L, Ramachandra, E, Noss, W H, Boom, C V, Harding   +3 more
openaire   +4 more sources

Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. [PDF]

Proceedings of the National Academy of Sciences, 1995
The presentation of antigenic peptides by major histocompatibility complex (MHC) class II molecules to CD4+ T cells is critical to the function of the immune system. In this study, we have utilized the sorting signal of the lysosomal-associated membrane protein LAMP-1 to target a model antigen, human papillomavirus 16 E7 (HPV-16 E7), into the endosomal
Kathleen R. Cho, Drew M. Pardoll, J. T. August, Tzyy Choou Wu, Lora Hedrick, Hyam I. Levitsky, Kevin Staveley-O'Carroll, Raphael P. Viscidi, Frank G. Guarnieri   +8 more
openaire   +4 more sources

Mutations and selection in the generation of class II histocompatibility antigen polymorphism. [PDF]

The EMBO Journal, 1984
A comparison of seven human DR and DC class II histocompatibility antigen beta-chain amino acid sequences indicates that the allelic variation is of comparable magnitude within the DR and DC beta-chain genes. Silent and replacement nucleotide substitutions in six DR and DC beta-chain sequences, as well as in seven murine class II sequences (three I-A ...
Kenth Gustafsson, E. Emmoth, Lars Rask, J Böhme, Hans Ronne, J J Hyldig-Nielsen, K. Wiman, Per A. Peterson, Dan Larhammar   +8 more
openaire   +3 more sources

Minors come of age: minor histocompatibility antigens and graft-versus-host disease [PDF]

, 2004
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Chao, Nelson J
core   +1 more source

CHARACTER OF DISTRIBUTION OF HLA II ANTIGENS IN PATIENTS WITH AVERAGE AND SEVERE FORMS OF ACNE

Vestnik Dermatologii i Venerologii, 2018
This article presents information about the distribution of antigens of the second class in patients with papulo-pustular and nodulous forms of acne.
V. V. Ryabova, S. V. Koshkin, G. A. Zaitseva, A. L. Evseeva   +3 more
doaj   +1 more source

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products

Journal of Experimental Medicine, 1995
We have previously demonstrated that human peripheral blood low density mononuclear cells cultured in granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4 develop into dendritic cells (DCs) that are extremely efficient in ...
F. Sallusto, M. Cella, Carlo Danieli, A. Lanzavecchia   +3 more
semanticscholar   +1 more source

Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells. [PDF]

PLoS ONE, 2010
BACKGROUND: Major histocompatibility complex (MHC) antigens are important for alloimmune responses as well as immune tolerance. Previous studies have shown that presentation of donor MHC antigens by donor-specific transfusion prior to or upon ...
Shuzi Zhang, Hehua Dai, Ni Wan, Yolonda Moore, Zhenhua Dai   +4 more
doaj   +1 more source

Antigen processing for MHC presentation by autophagy [PDF]

, 2010
Autophagy delivers cytoplasmic constituents for lysosomal degradation. This catabolic pathway can be used to deliver intracellular antigens for major histocompatibility complex (MHC) class II presentation.
Münz, Christian
core   +3 more sources

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

Frontiers in Immunology, 2017
Antigen presentation by major histocompatibility complex (MHC) proteins is essential for adaptive immunity. Prior to presentation, peptides need to be generated from proteins that are either produced by the cell’s own translational machinery or that are ...
M. Wieczorek, Esam T. Abualrous, J. Sticht, Miguel Álvaro-Benito, Sebastian Stolzenberg, F. Noé, C. Freund   +6 more
semanticscholar   +1 more source