Results 31 to 40 of about 108,384 (342)

Signal Recognition Particle-dependent Membrane Insertion of Mouse Invariant Chain: A Membrane-spanning Protein with a Cytoplasmically Exposed Amino Terminus [PDF]

, 1986
Invariant (Ii) chain is a membrane-spanning protein that is found associated intracellularly with class II histocompatibility antigens. In the endoplasmic reticulum Ii chain spans the membrane and exposes the NH2 terminus on the cytoplasmic and the COOH
Dobberstein, Bernhard, Lipp, Joachim
core   +1 more source

Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages

, 2000
During African trypanosomiasis, macrophages play a central role in T cell hyporesponsiveness to parasite-related and unrelated antigens. In this study, the ability of macrophages from Trypanosoma b. brucei-infected mice to present exogenous antigens to a
Beschin, A, Brys, L, De Baetselier, P, Magez, Stefan, Namangala, B   +4 more
core   +2 more sources

Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers. [PDF]

, 2020
The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during ...
Barcellos, Lisa F, Blasczyk, Rainer, Busch, Michael P, Criswell, Lindsey A, Cruz, Giovanna I, Ho, Kimberly A, Ladas, Nektarios, Niederhuber, John E, Noble, Janelle A, Patsopoulos, Nikolaos A, Quach, Diana, Quach, Hong, Shao, Xiaorong, Solomon, Benjamin D, Sterba, Kirsten, Triulzi, Darrell J, Wong, Wendy SW   +16 more
core  

Murine liver allograft transplantation: Tolerance and donor cell chimerism [PDF]

, 1994
Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity ...
Arnold, Billingham, Billingham, Billingham, Calne, Calne, Cohen, Corry, Coutinho, Dahmen, Davies, Demetris, Demetris, Garnier, Goulmy, Hoffmann, Houssaint, Jerne, Kamada, Liegeois, Liegeois, Mayumi, Monaco, Monaco, Murase, Ono, Peacock, Perelson, Qian, Rao, Russell, Russell, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steinman, Steinman, Strelein, Thomas, Wood, Zimmerman   +45 more
core   +1 more source

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. [PDF]

, 2015
Background/objectivesThe common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD).
Boss, JM, Bronstein, J, Chang, J, Chung, J, Cook, DA, Factor, SA, Kannarkat, GT, Lee, J-K, Paul, KC, Ritz, B, Sandy, E, Tansey, MG   +11 more
core   +2 more sources

Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans. [PDF]

, 2020
Here we studied HLA blocks and haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation sequencing (NGS) method.
Aguilar-Vázquez, José Artemio, Barquera, Rodrigo, Barsakis, Konstantinos, Corona, Teresa, Cruz-Lagunas, Alfredo, Fernández-Viña, Marcelo, Flores-Rivera, José, García-Lechuga, Maricela, Granados, Julio, Hernández-Zaragoza, Diana Iraíz, Jiménez-Alvarez, Luis, Jonapá-Gómez, Letisia, Mallempati, Kalyan C, Mena-Hernández, Lourdes, Mindrinos, Michael, Ochoa-Morales, Adriana, Ortega, Esteban, Penman, Bridget S., Soler, Manuel, Tovar-Méndez, Víctor Hugo, Yescas, Petra, Yunis, Edmond, Yunis, María, Zuniga, Joaquin   +23 more
core   +1 more source

Regulation of major histocompatibility complex class II gene expression in trophoblast cells

Reproductive Biology and Endocrinology, 2004
Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-γ.
Choi Jason C, Murphy Shawn P, Holtz Renae   +2 more
doaj   +1 more source

Mutations and selection in the generation of class II histocompatibility antigen polymorphism. [PDF]

The EMBO Journal, 1984
A comparison of seven human DR and DC class II histocompatibility antigen beta-chain amino acid sequences indicates that the allelic variation is of comparable magnitude within the DR and DC beta-chain genes. Silent and replacement nucleotide substitutions in six DR and DC beta-chain sequences, as well as in seven murine class II sequences (three I-A ...
K, Gustafsson, K, Wiman, E, Emmoth, D, Larhammar, J, Böhme, J J, Hyldig-Nielsen, H, Ronne, P A, Peterson, L, Rask   +8 more
openaire   +2 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

iScience, 2019
Summary: Antigen presentation to T cells in major histocompatibility complex class II (MHC class II) requires the conversion of early endo/phagosomes into lysosomes by a process called maturation.
Maksim V. Baranov, Frans Bianchi, Anastasiya Schirmacher, Melissa A.C. van Aart, Sjors Maassen, Elke M. Muntjewerff, Ilse Dingjan, Martin ter Beest, Martijn Verdoes, Samantha G.L. Keyser, Carolyn R. Bertozzi, Ulf Diederichsen, Geert van den Bogaart   +12 more
doaj   +1 more source