Results 1 to 10 of about 617,156 (199)

Impaired Regulation of Histone Methylation and Acetylation Underlies Specific Neurodevelopmental Disorders

Frontiers in Genetics, 2021
Epigenetic processes are critical for governing the complex spatiotemporal patterns of gene expression in neurodevelopment. One such mechanism is the dynamic network of post-translational histone modifications that facilitate recruitment of transcription
Merrick S. Fallah, Merrick S. Fallah, Dora Szarics, Dora Szarics, Clara M. Robson, Clara M. Robson, James H. Eubanks, James H. Eubanks, James H. Eubanks, James H. Eubanks, James H. Eubanks   +10 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

Cells, 2020
The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law, Fatima Valdes-Mora, David Gallego-Ortega   +2 more
doaj   +1 more source

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Genome Biology, 2021
Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu, P. Chai, Minyue Xie, S. Ge, Jing Ruan, Xianqun Fan, Renbing Jia   +6 more
semanticscholar   +2 more sources

Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence [PDF]

Open Biology, 2018
Pioneer transcription factors specifically target their recognition DNA sequences within nucleosomes. FoxA is the pioneer transcription factor that binds to the ALB1 gene enhancer in liver precursor cells, and is required for liver differentiation in ...
Yoshimasa Takizawa, Hiroki Tanaka, Shinichi Machida, Masako Koyama, Kazumitsu Maehara, Yasuyuki Ohkawa, Paul A. Wade, Matthias Wolf, Hitoshi Kurumizaka   +8 more
doaj   +1 more source

Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

Circulation Research, 2022
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals.
Naixin Wang, Weiwei Wang, Xiaoqi Wang, G. Mang, Jianfeng Chen, Xiangyu Yan, Zhonghua Tong, Qiannan Yang, Mengdi Wang, Liangqi Chen, Ping Sun, Yupeng Yang, Jingxuan Cui, Mian Yang, Yafei Zhang, Dongni Wang, Jian Wu, Maomao Zhang, Bo Yu   +18 more
semanticscholar   +1 more source

Progressive Phosphorylation Modulates the Self-Association of a Variably Modified Histone H3 Peptide

Frontiers in Molecular Biosciences, 2021
Protein phosphorylation is a key regulatory mechanism in eukaryotic cells. In the intrinsically disordered histone tails, phosphorylation is often a part of combinatorial post-translational modifications and an integral part of the “histone code” that ...
George V. Papamokos, George V. Papamokos, George V. Papamokos, George Tziatzos, Dimitrios G. Papageorgiou, Spyros Georgatos, Spyros Georgatos, Efthimios Kaxiras, Anastasia S. Politou, Anastasia S. Politou   +9 more
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The First Analysis of Synaptonemal Complexes in Jawless Vertebrates: Chromosome Synapsis and Transcription Reactivation at Meiotic Prophase I in the Lamprey Lampetra fluviatilis (Petromyzontiformes, Cyclostomata)

Life, 2023
Transcription is known to be substage-specific in meiotic prophase I. If transcription is reactivated in the mid pachytene stage in mammals when synapsis is completed, then this process is observed in the zygotene stage in insects.
Sergey Matveevsky, Nikolay Tropin, Aleksandr Kucheryavyy, Oxana Kolomiets   +3 more
doaj   +1 more source

Heparin Attenuates Histone-Mediated Cytotoxicity in Septic Acute Kidney Injury

Frontiers in Medicine, 2020
Histones are considered potential risk factors that contribute to the development of septic acute kidney injury (SAKI) by inducing apoptosis and inflammation.
Ziyi Wang, Lijun Wang, Chao Cao, Heng Jin, Yan Zhang, Yancun Liu, Yulei Gao, Xue Liang, Guangping Li, Songtao Shou   +9 more
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Metabolic regulation of gene expression by histone lactylation

Nature, 2019
The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells.
Di Zhang, Zhanyun Tang, He Huang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel M. Czyż, Rong Hu, Z. Ye, Maomao He, Y. G. Zheng, H. Shuman, Lunzhi Dai, Lunzhi Dai, B. Ren, R. Roeder, L. Becker, Yingming Zhao   +23 more
semanticscholar   +1 more source

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

bioRxiv, 2021
Lysine l-lactylation [K(l-la)] is a newly discovered histone mark that can be stimulated under conditions of high glycolysis, such as the Warburg effect. K(l-la) is associated with functions that are different from the widely studied histone acetylation.
Carlos Moreno-Yruela, Di Zhang, Wei Wei, Michael Bæk, Wenchao Liu, Jinjun Gao, D. Danková, Alexander L. Nielsen, Julie E Bolding, Lu Yang, Samuel T. Jameson, J. Wong, C. Olsen, Yingming Zhao   +13 more
semanticscholar   +1 more source