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DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
Cell Reports, 2021 Summary: Histone lysine methylation functions at the interface of the extracellular environment and intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known ...
Tanjing Song +9 more
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Journal of Integrative Agriculture, 2023 Chromatin accessibility plays a vital role in gene transcriptional regulation. However, the regulatory mechanism of chromatin accessibility, as well as its role in regulating crucial gene expression and kernel development in maize (Zea mays) are poorly ...
Si-di XIE +8 more
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Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Peterson, Craig L, Laniel, Marc-André
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Frontiers in Genetics, 2021 Epigenetic processes are critical for governing the complex spatiotemporal patterns of gene expression in neurodevelopment. One such mechanism is the dynamic network of post-translational histone modifications that facilitate recruitment of transcription
Merrick S. Fallah +10 more
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Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
Cells, 2020 The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law +2 more
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Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence [PDF]
Open Biology, 2018 Pioneer transcription factors specifically target their recognition DNA sequences within nucleosomes. FoxA is the pioneer transcription factor that binds to the ALB1 gene enhancer in liver precursor cells, and is required for liver differentiation in ...
Yoshimasa Takizawa +8 more
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Progressive Phosphorylation Modulates the Self-Association of a Variably Modified Histone H3 Peptide
Frontiers in Molecular Biosciences, 2021 Protein phosphorylation is a key regulatory mechanism in eukaryotic cells. In the intrinsically disordered histone tails, phosphorylation is often a part of combinatorial post-translational modifications and an integral part of the “histone code” that ...
George V. Papamokos +9 more
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Life, 2023 Transcription is known to be substage-specific in meiotic prophase I. If transcription is reactivated in the mid pachytene stage in mammals when synapsis is completed, then this process is observed in the zygotene stage in insects.
Sergey Matveevsky +3 more
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Heparin Attenuates Histone-Mediated Cytotoxicity in Septic Acute Kidney Injury
Frontiers in Medicine, 2020 Histones are considered potential risk factors that contribute to the development of septic acute kidney injury (SAKI) by inducing apoptosis and inflammation.
Ziyi Wang +9 more
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Histone-Histone Interactions and Centromere Function [PDF]
Molecular and Cellular Biology, 2000 Cse4p is a structural component of the core centromere of Saccharomyces cerevisiae and is a member of the conserved CENP-A family of specialized histone H3 variants. The histone H4 allele hhf1-20 confers defects in core centromere chromatin structure and mitotic chromosome transmission.
L, Glowczewski +4 more
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