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HISTONES AND DIFFERENTIATION [PDF]
Proceedings of the National Academy of Sciences, 1963 Betty C. Moore
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Frontiers in Genetics, 2021 Epigenetic processes are critical for governing the complex spatiotemporal patterns of gene expression in neurodevelopment. One such mechanism is the dynamic network of post-translational histone modifications that facilitate recruitment of transcription
Merrick S. Fallah +10 more
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Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Marc-André Laniel, Craig L. Peterson
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Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
Cells, 2020 The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law +2 more
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Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence [PDF]
Open Biology, 2018 Pioneer transcription factors specifically target their recognition DNA sequences within nucleosomes. FoxA is the pioneer transcription factor that binds to the ALB1 gene enhancer in liver precursor cells, and is required for liver differentiation in ...
Yoshimasa Takizawa +8 more
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Progressive Phosphorylation Modulates the Self-Association of a Variably Modified Histone H3 Peptide
Frontiers in Molecular Biosciences, 2021 Protein phosphorylation is a key regulatory mechanism in eukaryotic cells. In the intrinsically disordered histone tails, phosphorylation is often a part of combinatorial post-translational modifications and an integral part of the “histone code” that ...
George V. Papamokos +9 more
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Histone clipping: the punctuation in the histone code [PDF]
EMBO reports, 2021 Histone clipping was first discovered in the 1960s and still is a lingering mystery. Considering the essential roles of histones in regulating eukaryotic transcription through the histone code, clipping is a post-translational modification that appeals to the imagination.
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Life, 2023 Transcription is known to be substage-specific in meiotic prophase I. If transcription is reactivated in the mid pachytene stage in mammals when synapsis is completed, then this process is observed in the zygotene stage in insects.
Sergey Matveevsky +3 more
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Histones, histone chaperones and nucleosome assembly [PDF]
Protein & Cell, 2010 Chromatin structure governs a number of cellular processes including DNA replication, transcription, and DNA repair. During DNA replication, chromatin structure including the basic repeating unit of chromatin, the nucleosome, is temporarily disrupted, and then reformed immediately after the passage of the replication fork.
Rebecca J. Burgess, Zhiguo Zhang
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Heparin Attenuates Histone-Mediated Cytotoxicity in Septic Acute Kidney Injury
Frontiers in Medicine, 2020 Histones are considered potential risk factors that contribute to the development of septic acute kidney injury (SAKI) by inducing apoptosis and inflammation.
Ziyi Wang +9 more
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