Results 1 to 10 of about 570,523 (273)
Increased histone citrullination in juvenile idiopathic arthritis
Frontiers in Medicine, 2022 ObjectivePosttranslational modifications (PTMs) of proteins are crucial for regulating various biological processes. However, protein alteration via PTMs, and consequently, the creation of new epitopes, can induce abnormal autoimmune responses in ...
Zuzana Parackova +5 more
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Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Marc-André Laniel, Craig L. Peterson
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HISTONES AND DIFFERENTIATION [PDF]
Proceedings of the National Academy of Sciences, 1963 Betty C. Moore
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Histone variants and modifications during abiotic stress response
Frontiers in Plant Science, 2022 Plants have developed multiple mechanisms as an adaptive response to abiotic stresses, such as salinity, drought, heat, cold, and oxidative stress. Understanding these regulatory networks is critical for coping with the negative impact of abiotic stress ...
Rocío Nunez-Vazquez +2 more
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Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
Cells, 2020 The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law +2 more
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Heparin Attenuates Histone-Mediated Cytotoxicity in Septic Acute Kidney Injury
Frontiers in Medicine, 2020 Histones are considered potential risk factors that contribute to the development of septic acute kidney injury (SAKI) by inducing apoptosis and inflammation.
Ziyi Wang +9 more
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Frontiers in Cardiovascular Medicine, 2022 BackgroundPatients successfully resuscitated from cardiac arrest often develop organ dysfunction caused by systemic inflammation and increased coagulation, leading to disseminated intravascular coagulation (DIC).
Asumi Mizugaki +4 more
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Progressive Phosphorylation Modulates the Self-Association of a Variably Modified Histone H3 Peptide
Frontiers in Molecular Biosciences, 2021 Protein phosphorylation is a key regulatory mechanism in eukaryotic cells. In the intrinsically disordered histone tails, phosphorylation is often a part of combinatorial post-translational modifications and an integral part of the “histone code” that ...
George V. Papamokos +9 more
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Genome Biology, 2021 Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu +6 more
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Crosstalk Between mRNA 3'-End Processing and Epigenetics
Frontiers in Genetics, 2021 The majority of eukaryotic genes produce multiple mRNA isoforms by using alternative poly(A) sites in a process called alternative polyadenylation (APA).
Lindsey V. Soles, Yongsheng Shi
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