Results 11 to 20 of about 617,156 (199)

Early Life Stress- and Drug-Induced Histone Modifications Within the Ventral Tegmental Area

Frontiers in Cell and Developmental Biology, 2020
Psychiatric illnesses are a major public health concern due to their prevalence and heterogeneity of symptom presentation resulting from a lack of efficacious treatments.
Ryan D. Shepard, Fereshteh S. Nugent
doaj   +1 more source

Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues

Nature Biotechnology, 2021
In contrast to single-cell approaches for measuring gene expression and DNA accessibility, single-cell methods for analyzing histone modifications are limited by low sensitivity and throughput.
Marek Bartošovič, Mukund Kabbe, G. Castelo-Branco   +2 more
semanticscholar   +1 more source

Sample Volume Reduction Using the Schwarzschild Objective for a Circular Dichroism Spectrophotometer and an Application to the Structural Analysis of Lysine-36 Trimethylated Histone H3 Protein

Molecules, 2018
With the increasing interest in scarce proteins, reducing the sample volume for circular dichroism (CD) spectroscopy has become desirable. Demagnification of the incident beam size is required to reduce the sample volume for CD spectroscopy detecting ...
Yudai Izumi, Koichi Matsuo
doaj   +1 more source

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

Journal of Biological Chemistry, 1998
When mammalian cell cultures or mice are exposed to ionizing radiation in survivable or lethal amounts, novel mass components are found in the histone H2A region of two-dimensional gels.
E. Rogakou, D. Pilch, A. Orr, V. Ivanova, W. Bonner   +4 more
semanticscholar   +1 more source

Multifaceted Targeting of the Chromatin Mediates Gonadotropin-Releasing Hormone Effects on Gene Expression in the Gonadotrope

Frontiers in Endocrinology, 2018
Gonadotropin-releasing hormone (GnRH) stimulates the expression of multiple genes in the pituitary gonadotropes, most notably to induce synthesis of the gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), but also to ensure ...
Philippa Melamed, Majd Haj, Yahav Yosefzon, Sergei Rudnizky, Andrea Wijeweera, Lilach Pnueli, Ariel Kaplan   +6 more
doaj   +1 more source

A Positive Feedback Loop between Inactive VHL-Triggered Histone Lactylation and PDGFRβ Signaling Drives Clear Cell Renal Cell Carcinoma Progression

International Journal on Biological Sciences, 2022
Inactive von Hippel-Lindau (VHL) is linked to metabolic reprogramming and plays pivotal roles in the pathogenesis of clear cell renal cell carcinoma (ccRCC).
Jiefeng Yang, Li Luo, Chongyu Zhao, Xiyuan Li, Zimo Wang, Z. Zeng, Xin Yang, Xiaobin Zheng, H. Jie, Liang Kang, Shujuan Li, Shuang Liu, Chi Zhou, Huashan Liu   +13 more
semanticscholar   +1 more source

The Secret Language of Destiny: Stress Imprinting and Transgenerational Origins of Disease

Frontiers in Genetics, 2012
Epigenetic regulation modulates gene expression without altering the DNA sequence to facilitate rapid adjustments according to current environmental conditions.
Fabiola Cristina Ribeiro Zucchi, Youli eYao, Youli eYao, Gerlinde A.S. Metz   +3 more
doaj   +1 more source

Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer

Nature Communications, 2017
Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers.
Fátima Valdés-Mora, Cathryn M. Gould, Yolanda Colino-Sanguino, Wenjia Qu, Jenny Z. Song, Kylie M. Taylor, Fabian A. Buske, Aaron L. Statham, Shalima S. Nair, Nicola J. Armstrong, James G. Kench, Kenneth M. L. Lee, Lisa G. Horvath, Minru Qiu, Alexei Ilinykh, Nicole S. Yeo-Teh, David Gallego-Ortega, Clare Stirzaker, Susan J. Clark   +18 more
doaj   +1 more source

MicroRNAs as new Characters in the Plot between Epigenetics and Prostate Cancer

Frontiers in Genetics, 2011
Prostate cancer (PCA) still represents a leading cause of death. An increasing number of studies have documented that microRNAs (miRNAs), a subgroup of non-coding RNAs with gene regulatory functions, are differentially expressed in PCA respect to the ...
Alessio ePaone, Roberta eGalli, Muller eFabbri   +2 more
doaj   +1 more source

Molecular Insights into Epigenetics and Cannabinoid Receptors

Biomolecules, 2022
The actions of cannabis are mediated by G protein-coupled receptors that are part of an endogenous cannabinoid system (ECS). ECS consists of the naturally occurring ligands N-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), their ...
Balapal S. Basavarajappa, Shivakumar Subbanna   +1 more
doaj   +1 more source