Results 11 to 20 of about 570,523 (273)

Histone clipping: the punctuation in the histone code [PDF]

open access: yesEMBO reports, 2021
Histone clipping was first discovered in the 1960s and still is a lingering mystery. Considering the essential roles of histones in regulating eukaryotic transcription through the histone code, clipping is a post-translational modification that appeals to the imagination.
openaire   +3 more sources

Extraction, Identification, Modification, and Antibacterial Activity of Histone from Immature Testis of Atlantic salmon

open access: yesMarine Drugs, 2020
In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated.
Boyu Fu   +4 more
doaj   +1 more source

Histones, histone chaperones and nucleosome assembly [PDF]

open access: yesProtein & Cell, 2010
Chromatin structure governs a number of cellular processes including DNA replication, transcription, and DNA repair. During DNA replication, chromatin structure including the basic repeating unit of chromatin, the nucleosome, is temporarily disrupted, and then reformed immediately after the passage of the replication fork.
Rebecca J. Burgess, Zhiguo Zhang
openaire   +3 more sources

Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues

open access: yesNature Biotechnology, 2021
In contrast to single-cell approaches for measuring gene expression and DNA accessibility, single-cell methods for analyzing histone modifications are limited by low sensitivity and throughput.
Marek Bartošovič   +2 more
semanticscholar   +1 more source

Multiple Site-Specific One-Pot Synthesis of Two Proteins by the Bio-Orthogonal Flexizyme System

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
Lysine acetylation is a reversible post-translational modification (PTM) vastly employed in many biological events, including regulating gene expression and dynamic transitions in chromatin remodeling.
Qiuyun Xiao   +4 more
doaj   +1 more source

Translating the Histone Code

open access: yesScience, 2001
Chromatin, the physiological template of all eukaryotic genetic information, is subject to a diverse array of posttranslational modifications that largely impinge on histone amino termini, thereby regulating access to the underlying DNA. Distinct histone
T. Jenuwein, C. Allis
semanticscholar   +1 more source

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

open access: yesbioRxiv, 2021
Lysine l-lactylation [K(l-la)] is a newly discovered histone mark that can be stimulated under conditions of high glycolysis, such as the Warburg effect. K(l-la) is associated with functions that are different from the widely studied histone acetylation.
Carlos Moreno-Yruela   +13 more
semanticscholar   +1 more source

Stochastic epigenetic dynamics of gene switching [PDF]

open access: yesPhys. Rev. E 102, 042408 (2020), 2020
Epigenetic modifications of histones crucially affect the eukaryotic gene activity, while the epigenetic histone state is largely determined by the binding of specific factors such as the transcription factors (TFs) to DNA. Here, the way how the TFs and the histone state are dynamically correlated is not obvious when the TF synthesis is regulated by ...
arxiv   +1 more source

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

open access: yesJournal of Biological Chemistry, 1998
When mammalian cell cultures or mice are exposed to ionizing radiation in survivable or lethal amounts, novel mass components are found in the histone H2A region of two-dimensional gels.
E. Rogakou   +4 more
semanticscholar   +1 more source

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