Results 21 to 30 of about 772,216 (334)

MicroRNAs as new Characters in the Plot between Epigenetics and Prostate Cancer

Frontiers in Genetics, 2011
Prostate cancer (PCA) still represents a leading cause of death. An increasing number of studies have documented that microRNAs (miRNAs), a subgroup of non-coding RNAs with gene regulatory functions, are differentially expressed in PCA respect to the ...
Alessio ePaone, Roberta eGalli, Muller eFabbri   +2 more
doaj   +1 more source

The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma

Dermatologica Sinica, 2023
Primary cutaneous mucinous carcinoma (PCMC) is rare, and its carcinogenesis is unclear. Trimethylation of histone H3 at lysine 27 (H3K27me3) is a key regulator in chromatin remodeling-controlled transcription.
Shu-Hao Li, Chien-Chun Chiou, Chien-Chin Chen   +2 more
doaj   +1 more source

Epigenetic Alterations in Human Papillomavirus-Associated Cancers

Viruses, 2017
Approximately 15–20% of human cancers are caused by viruses, including human papillomaviruses (HPVs). Viruses are obligatory intracellular parasites and encode proteins that reprogram the regulatory networks governing host cellular signaling pathways ...
David Soto, Christine Song, Margaret E. McLaughlin-Drubin   +2 more
doaj   +1 more source

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

Extracting histones for the specific purpose of label-free MS [PDF]

, 2016
Extracting histones from cells is the first step in studies that aim to characterize histones and their post-translational modifications (hPTMs) with MS.
De Clerck, Laura, Deforce, Dieter, Dhaenens, Maarten, Govaert, Elisabeth, Meert, Paulien, Scheerlinck, Ellen, Stella, Martina, Van Steendam, Katleen, Vossaert, Liesbeth, Willems, Sander   +9 more
core   +2 more sources

Similarities between the Epstein-Barr Virus (EBV) Nuclear Protein EBNA1 and the Pioneer Transcription Factor FoxA: Is EBNA1 a “Bookmarking” Oncoprotein that Alters the Host Cell Epigenotype?

Pathogens, 2012
EBNA1, a nuclear protein expressed in all EBV-associated neoplasms is indispensable for the maintenance of the viral episomes in latently infected cells.
Hans Helmut Niller, Janos Minarovits
doaj   +1 more source

Histone chaperones regulate histone exchange during transcription [PDF]

The EMBO Journal, 2007
Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway,
Hye-Jin, Kim, Ja-Hwan, Seol, Jeung-Whan, Han, Hong-Duk, Youn, Eun-Jung, Cho   +4 more
openaire   +2 more sources

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection. [PDF]

, 2017
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Alland, Aung, Azad, Bannister, Barchowsky, Bell, Bird, Brilha, Chen, Chernov, Choudhary, Culley, de Ruijter, Dobaczewski, Elkington, Feng, Goldberg, Green, Gregoire, Gregoretti, Horiuchi, Jaspers, Khan, Kim, Kleinsteuber, Kubler, Kumar, Lee, Loffek, Lu, Maciejewska-Rodrigues, Majeed, McErlean, McGarry Houghton, Michael, Mittelstadt, Mortaz, Moser, Nasu, Omanakuttan, Ong, Ong, Roger, Shahbazian, Shammari, Singh, Swamy, Tezera, Thuong, Wallis, Wang, Wang, Wolffe   +52 more
core   +2 more sources

Epigenetic Regulation of Autophagy: A Path to the Control of Autoimmunity

Frontiers in Immunology, 2018
Autoimmune diseases are a significant cause of debilitation and mortality globally and are in need of cost-effective therapeutics. Autophagy is a cellular pathway that facilitates immune modulation involved in both pathogen control and autoimmunity ...
Jessica C. Hargarten, Peter R. Williamson   +1 more
doaj   +1 more source

Depletion of ATP-citrate lyase (ATPCL) affects chromosome integrity without altering histone acetylation in Drosophila mitotic cells [PDF]

, 2019
The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitochondria by the SLC25A1 carrier in Acetyl Coenzyme A (acetyl-CoA) and oxaloacetate.
CENCI, GIOVANNI, DI GIORGIO, MARIA LAURA, LICURSI, Valerio, MORCIANO, PATRIZIA, NEGRI, RODOLFO, PORRAZZO, ANTONELLA, Yikang, Rong   +6 more
core   +2 more sources