The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution [PDF]
, 2013 NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a ...
Andrew Bowman +53 more
core +7 more sources
Histones join the fight against bacteria inside cells
eLife, 2012 Experiments on Drosophila have shown that the histones that are normally bound to lipid droplets inside cells can be released to provide protection against infection.
Roberto Kolter
doaj +1 more source
The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]
, 2011 Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, A. +6 more
core +4 more sources
Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells
eLife, 2018 Transcription of protein coding genes is accompanied by recruitment of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form H3K4me1, H3K4me2 and H3K4me3.
Cristina Cruz +7 more
doaj +1 more source
Frontiers in Genetics, 2021 Epigenetic processes are critical for governing the complex spatiotemporal patterns of gene expression in neurodevelopment. One such mechanism is the dynamic network of post-translational histone modifications that facilitate recruitment of transcription
Merrick S. Fallah +10 more
doaj +1 more source
Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence [PDF]
Open Biology, 2018 Pioneer transcription factors specifically target their recognition DNA sequences within nucleosomes. FoxA is the pioneer transcription factor that binds to the ALB1 gene enhancer in liver precursor cells, and is required for liver differentiation in ...
Yoshimasa Takizawa +8 more
doaj +1 more source
The Histone Database: an integrated resource for histones and histone fold-containing proteins [PDF]
Database, 2011 Eukaryotic chromatin is composed of DNA and protein components-core histones-that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and ...
Andreas D. Baxevanis +6 more
openaire +3 more sources
The Histone 3'-Terminal Stem-Loop-Binding Protein Enhances Translation through a Functional and Physical Interaction with Eukaryotic Initiation Factor 4G (eIF4G) and eIF3 [PDF]
, 2002 Metazoan cell cycle-regulated histone mRNAs are unique cellular mRNAs in that they terminate in a highly conserved stem-loop structure instead of a poly(A) tail.
Gallie, Daniel R +4 more
core +4 more sources
Pathogens, 2012 EBNA1, a nuclear protein expressed in all EBV-associated neoplasms is indispensable for the maintenance of the viral episomes in latently infected cells.
Hans Helmut Niller, Janos Minarovits
doaj +1 more source
Extracting histones for the specific purpose of label-free MS [PDF]
, 2016 Extracting histones from cells is the first step in studies that aim to characterize histones and their post-translational modifications (hPTMs) with MS.
De Clerck, Laura +9 more
core +2 more sources