Results 21 to 30 of about 570,523 (273)
Histone-Histone Interactions and Centromere Function [PDF]
Molecular and Cellular Biology, 2000 Cse4p is a structural component of the core centromere of Saccharomyces cerevisiae and is a member of the conserved CENP-A family of specialized histone H3 variants. The histone H4 allele hhf1-20 confers defects in core centromere chromatin structure and mitotic chromosome transmission.
M. Mitchell Smith +4 more
openaire +3 more sources
The Secret Language of Destiny: Stress Imprinting and Transgenerational Origins of Disease
Frontiers in Genetics, 2012 Epigenetic regulation modulates gene expression without altering the DNA sequence to facilitate rapid adjustments according to current environmental conditions.
Fabiola Cristina Ribeiro Zucchi +3 more
doaj +1 more source
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Proceedings of the National Academy of Sciences of the United States of America, 2010 Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome.
M. Creyghton +12 more
semanticscholar +1 more source
Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
Nature Communications, 2017 Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers.
Fátima Valdés-Mora +18 more
doaj +1 more source
The activity-dependent histone variant H2BE modulates the life span of olfactory neurons
eLife, 2012 We have identified a replication-independent histone variant, Hist2h2be (referred to herein as H2be), which is expressed exclusively by olfactory chemosensory neurons. Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to
Stephen W Santoro, Catherine Dulac
doaj +1 more source
Peeling and Sliding in Nucleosome Repositioning [PDF]
Phys. Rev. Lett., 99, 058105, (2007), 2007 We investigate the mechanisms of histone sliding and detachment with a stochastic model that couples thermally-induced, passive histone sliding with active motor-driven histone unwrapping. Analysis of a passive loop or twist defect-mediated histone sliding mechanism shows that diffusional sliding is enhanced as larger portions of the DNA is peeled off ...
arxiv +1 more source
Histones join the fight against bacteria inside cells
eLife, 2012 Experiments on Drosophila have shown that the histones that are normally bound to lipid droplets inside cells can be released to provide protection against infection.
Roberto Kolter
doaj +1 more source
The Histone Database: an integrated resource for histones and histone fold-containing proteins [PDF]
Database, 2011 Eukaryotic chromatin is composed of DNA and protein components-core histones-that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and ...
Andreas D. Baxevanis +6 more
openaire +3 more sources
Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells
eLife, 2018 Transcription of protein coding genes is accompanied by recruitment of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form H3K4me1, H3K4me2 and H3K4me3.
Cristina Cruz +7 more
doaj +1 more source
Frontiers in Genetics, 2021 Epigenetic processes are critical for governing the complex spatiotemporal patterns of gene expression in neurodevelopment. One such mechanism is the dynamic network of post-translational histone modifications that facilitate recruitment of transcription
Merrick S. Fallah +10 more
doaj +1 more source