Results 221 to 230 of about 189,363 (327)

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency. [PDF]

Epigenetics Chromatin
Venu V, Small EM, Roth C, Adikari SH, Vlot AHC, Sullivan KA, Abeyratne CR, Jacobson D, Starkenburg SR, Sanbonmatsu KY, Steadman CR.   +10 more
europepmc   +1 more source

The Regulation of Hippocampal Synaptic Plasticity by Upstream and Downstream Effectors of Histone Acetylation

, 2015
Morgan S. Bridi
openalex   +1 more source

Profiling Protein Citrullination in Extracellular Vesicles by Single‐Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy

Journal of Biophotonics, EarlyView.
This study identifies post‐translationally citrullinated/deiminated protein cargoes co‐localised to EV subtypes, using super resolution microscopy and dSTORM imaging. The findings expand current understanding of post‐translational modifications in EV‐mediated cellular communication.
Sarah R. Needham, Benjamin M. Davis, Pinar Uysal‐Onganer, Daniel J. Rolfe, Mariya Hristova, Igor Kraev, Jameel M. Inal, Sigrun Lange   +7 more
wiley   +1 more source

Histone acetylation modulation by a small molecule inhibitor recapitulates symbiont-induced cytoplasmic incompatibility. [PDF]

Cell Rep
Kaur R, Kalra M, Imchen M, Crowley BL, McGarry A, Carpenter L, Bordenstein SR.   +6 more
europepmc   +1 more source

Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β

, 2011
Fernando Corrêa, Carina Mallard, Michael Nilsson, Mats Sandberg   +3 more
openalex   +2 more sources

Genome‐wide association study of periodontitis severity and progression

Journal of Periodontology, EarlyView.
Abstract Background To add to the knowledge base of periodontal genomics, we carried out a genome‐wide association study (GWAS) of periodontitis severity and progression among 416 mixed‐ethnicity adult participants of a periodontitis clinical study. Methods Participants were 168 adults (mean age = 50 years, 46% males) with severe periodontitis and 248 ...
Flavia Teles, Ganesh Chandrasekaran, Lynn Martin, Poojan Shrestha, Kevin Moss, Michele Patel, Michael J. Kallan, Camila Furquim, Andrew J. Cucchiara, James D. Beck, Kari E. North, Joseph Glessner, Kimon Divaris   +12 more
wiley   +1 more source

FGF2 supports NANOG expression via pyruvate dehydrogenase-dependent histone acetylation under low oxygen conditions. [PDF]

Front Cell Dev Biol
Fojtík P, Senfluk M, Holomkova K, Salykin A, Gregorova J, Smak P, Pes O, Raska J, Beckerova D, Stetkova M, Skladal P, Sedlackova M, Hampl A, Bohaciakova D, Uldrijan S, Rotrekl V.   +15 more
europepmc   +1 more source

Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis

, 2015
Jun Che, Stephanie Smith, Yoo Jung Kim, Eun Yong Shim, Kyungjae Myung, Sang Eun Lee   +5 more
openalex   +2 more sources

Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities

Journal of Periodontology, EarlyView.
Abstract Historically, immunological memory was considered an exclusive feature of adaptive immunity. However, innate immune cells have recently been shown to record and maintain epigenetically imprinted memory of earlier infectious or inflammatory challenges.
George Hajishengallis
wiley   +1 more source