Results 211 to 220 of about 115,732 (260)
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Patterns of histone acetylation
European Journal of Biochemistry, 1990The N‐terminal domains of all four core histones are subject to reversible acetylation at certain lysine residues. This modification has been functionally linked to transcription, histone deposition at replication and to histone removal during spermatogenesis.
A W, Thorne +4 more
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Histone acetylation and cancer
Current Opinion in Genetics & Development, 1999In the past year, several papers have been published which implicate a link between alterations in chromatin structure and the development of cancer. Both histone hyperacetylation and hypoacetylation appear to be important in the neoplastic process, depending on the target gene involved. In the case of colon cancer, induction of the p21 gene by histone
S Y, Archer, R A, Hodin
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Acetylation of histones in nucleosomes
Molecular and Cellular Biochemistry, 1982A short review is given on the biochemistry of histone acetylation. Sites of acetylation in nucleosomal histones and enzymes involved in acetylation and deacetylation are discussed. Studies relating to the influence of these modifications on the structure of nucleosomes and chromatin are especially emphasized in this article.
D, Doenecke, D, Gallwitz
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Life Sciences, 1981
Abstract Myocardial histone acetylation was investigated in an isolated perfused heart preparation. Radioactive acetate rapidly accumulated in the intracellular compartment which preceded the covalent modification of histones. The acetylation of nucleohistones was rapid and reached a maximum during the first 20 min of perfusion.
P B, Taylor, E A, Cook
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Abstract Myocardial histone acetylation was investigated in an isolated perfused heart preparation. Radioactive acetate rapidly accumulated in the intracellular compartment which preceded the covalent modification of histones. The acetylation of nucleohistones was rapid and reached a maximum during the first 20 min of perfusion.
P B, Taylor, E A, Cook
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Nonenzymatic acetylation of histones with acetyl-CoA
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1970Abstract 1. When purified calf thymus histones were incubated with [1-14C]acetyl-CoA and treated to remove the acid-soluble fraction with trichloroacetic acid, a large amount of radioactivity still remained in the 15 % trichloroacetic acid-insoluble precipitate. 2.
W K, Paik, D, Pearson, H W, Lee, S, Kim
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Nonenzymic acetylation of histones with acetyl phosphate and acetyl adenylate
Biochemistry, 1975Nonenzymatic acetylation of calf-thymus lysine- and arginine-rich histones was demonstrated to occur when these proteins were incubated with [14C]acetyl phosphate and [14C]acetyl adenylate. The levels of acetylation depend on both pH and on reagent concentration.
RAMPONI, GIAMPIETRO +2 more
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TiPpIng the balance in histone acetylation
Nature Metabolism, 2021Nutrient availability and the cell cycle are known to affect chromatin accessibility. A fundamental question is which mechanisms are involved in connecting nutrient levels, the cell cycle and chromatin regulation. In this issue, Zhang et al. reveal a signalling cascade whereby nutrient-sensing mTORC1 activates the cell-cycle regulator CDK2, thus ...
Lara Roach, Raul Mostoslavsky
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Histone acetylation and X inactivation
Developmental Genetics, 1998In mammals, the levels of X-linked gene products in males and females are equalised by the silencing, early in development, of most of the genes on one of the two female X chromosomes. Once established, the silent state is stable from one cell generation to the next. In eutherian mammals, the inactive X chromosome (Xi) differs from its active homologue
A M, Keohane +3 more
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Histone acetylation and deacetylation in yeast
Nature Reviews Molecular Cell Biology, 2003Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an untargeted and global manner, by affecting most nucleosomes. Recently, new roles for histone acetylation have been uncovered, not only in transcription but also in DNA replication, repair ...
Siavash K, Kurdistani +1 more
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Histone Acetylation in Insect Chromosomes
Science, 1968Acetylation of histones takes place along the salivary gland chromosomes of Chironomus thummi when RNA synthesis is active. It can be observed but not measured quantitatively by autoradiography of chromosome squashes.
V G, Allfrey +4 more
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