Results 221 to 230 of about 115,732 (260)

Histone Acetylation and Plant Development

2016
Reversible histone acetylation and deacetylation at the N-terminus of histone tails play a crucial role in regulation of gene activity. Hyperacetylation of histones relaxes chromatin structure and is associated with transcriptional activation, whereas hypoacetylation of histones induces chromatin compaction and gene repression.
X, Liu, S, Yang, C-W, Yu, C-Y, Chen, K, Wu   +4 more
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Temporal changes in histone acetylation

Mechanisms of Ageing and Development, 1978
The incorporation of tritiated acetate was studied in developing and aging rats. Thymus, liver and serum were collected 30 minutes after injection of acetate. The trichloroacetic acid precipitable histone fraction was then extracted from liver and thymus and its radioactivity determined. Serum and cytoplasmic fractions were also counted. Serum activity
M, Petricevic, C W, Denko, L, Messineo
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Histone Acetylation as a Therapeutic Target

2012
The recent developments in the field of epigenetics have changed the way the covalent modifications were perceived from mere chemical tags to important biological recruiting platforms as well as decisive factors in the process of transcriptional regulation and gene expression.
B Ruthrotha, Selvi, Snehajyoti, Chatterjee, Rahul, Modak, M, Eswaramoorthy, Tapas K, Kundu   +4 more
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Acetylation of histones of rat testis

Archives of Biochemistry and Biophysics, 1975
Abstract When [1- 14 C]acetate was injected into rats intratesticularly in the presence of cycloheximide to inhibit protein synthesis, the label was incorporated into histone fractions F2a1 and F3 and into non-histone chromosomal proteins of each of the following stages of spermatogenesis: spermatogonia-preleptotene spermatocytes, leptotene-zygotene ...
S R, Grimes, , Chae C-B, J L, Irvin
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Histone acetylation in chromatin and chromosomes

Seminars in Cell Biology, 1995
The packaging of DNA into chromatin is an important regulator of transcription. This regulation may operate either by short-term switching of the transcription of specific genes or by packaging chromosome domains into structures that either facilitate or repress the potential for gene expression.
B M, Turner, L P, O'Neill
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Genomewide histone acetylation microarrays

Methods, 2003
Histone acetylation and methylation are important regulators of gene activity. Chromatin immunoprecipitation (ChIP or ChrIP) has made it possible to examine not only the state of histone acetylation at a gene but also that of histone methylation and may soon be extended to other histone modifications such as phosphorylation and ubiquitination.
Daniel, Robyr, Michael, Grunstein
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Histone acetylation: chromatin in action

Trends in Biochemical Sciences, 1997
Histone acetylation acts as a landmark and determinant for chromatin function. Active roles in the transcription and assembly of chromatin have been discovered for histone acetyltransferases and deacetylases. This review highlights these roles and discusses their significance for the maintenance of cell differentiation.
P A, Wade, D, Pruss, A P, Wolffe
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In Vitro Histone Acetylation Assay

Current Protocols in Pharmacology, 2017
AbstractAcetylation is a core cellular process involved in maintaining genomic integrity, gene regulation, and metabolism. Histone acetyltransferases (HATs) are an enzyme family that regulates these processes by catalyzing the transfer of an acetyl moiety onto target proteins.
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Histone Acetylation and Chromatin Remodeling

Experimental Cell Research, 2001
Chromatin represents a repressive barrier to the process of transcription. This molecular obstacle is a highly dynamic structure, able to compact the DNA of the entire genome into the confines of a nucleus, and yet it allows access to the genetic information held within.
P D, Gregory, K, Wagner, W, Hörz
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Surrogate Alcohols and Their Metabolites Modify Histone H3 Acetylation: Involvement of Histone Acetyl Transferase and Histone Deacetylase

Alcoholism: Clinical and Experimental Research, 2008
Background:  Ethanol increases histone H3 acetylation in the rat liver. However, the effect of other carbon chain length alcohols, consumed as surrogate alcohols and used in industry, on H3 acetylation is unknown. Hence, we investigated the effect of these alcohols on histone H3 acetylation, cell toxicity and HAT and HDAC activity.Methods:  Primary ...
Mahua, Choudhury, Shivendra D, Shukla
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