Results 221 to 230 of about 404,910 (338)

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, EarlyView.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

Adolescent high fructose consumption induces cardiac dysfunction in adulthood via elevated histone acetylation. [PDF]

Transl Pediatr
Shen AN, Shi HQ, Zhang ZH, Yao Y, Zhao R, Shi Y, Zhao JY, Cai K, Wang F.   +8 more
europepmc   +1 more source

Nitric Oxide Modulates Histone Acetylation at Stress Genes by Inhibition of Histone Deacetylases1[OPEN]

Plant Physiology, 2016
Alexander Mengel, Alexandra Ageeva, Elisabeth Georgii, J. Bernhardt, Keqiang Wu, J. Durner, C. Lindermayr   +6 more
semanticscholar   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation. [PDF]

Nucleic Acids Res
Lambrechts LS, Reid XJ, Kambanis L, Luong C, Kobakhidze E, Daners A, Zhong Y, Patel K, Franck CK, Sani HM, Taylor C, Low JKK, Payne RJ, Mackay JP.   +13 more
europepmc   +1 more source

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source

Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of nucleosome arrays. [PDF]

Nat Commun
Gao J, Li H, Tan S, Zhou R, Lee TH.
europepmc   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders. [PDF]

Int J Biol Sci
Xu L, Shen C, Liu X, Qin Y, Wu Z, Zhang Z, Sheng Q, Wang Q, Zhou F, Ge G, Geng D.   +10 more
europepmc   +1 more source